There is still no consensus on the expression of the two isoforms in the human prostate and their cellular locations are also controversial. It is not known to which extent each of these isozymes contributes to overall enzyme activity in different prostatic tissues. In an attempt to elucidate which isoform of the 5α-reductases is responsible for the metabolism of T in normal and diseased human prostate, we performed qualitative and semi-quantitative studies of both enzymes in normal, benign hyperplastic and adenocarcinomatous human prostate tissues by RT-PCR and Immunohistochemistry methods.

現(xiàn)已成功地克隆出編碼Ⅰ型及Ⅱ型5α-還原酶的基因亚洲国品网站，關(guān)于這兩型5α-還原酶在前列腺組織及不同類型細(xì)胞中的存在、分布情況及其對(duì)組織中睪酮代謝各自所起的作用仍存在許多爭(zhēng)議成年男人黄网站色大片免，為此我們應(yīng)用RT-PCR及免疫組化方法對(duì)國人正常毛片a视频、良性增生以及前列腺癌組織中兩型5α-還原酶的表達(dá)進(jìn)行了定性和半定量研究。