Then Doripenem came into the market in the July ,2005. We studied the synthesis of Doripemen.Firstly, we synthesized the chemical 2 from the starting material------o-hydroxylphenylacylamine through Reformastky reaction, alkylation, Diekmann reaction, enolization, esterification and etc. Secondly, we synthesized the chemical 3 from L — hydroxylproline through the protection of carboxyl, amidogen and hydroxyl group, reduction by NaBr, SN_2 substitution and Mitsumobu reaction.

我們以水楊酰胺為起始原料，經(jīng)Reformatsky反應(yīng)综合色一色综合久久网88、烷基化、Diekmann環(huán)合、烯醇化免费看黄毛片A片人、酯化等反應(yīng)合成雙環(huán)母核2；再從L-羥基脯氨酸出發(fā)欧美A级孕妇A片，經(jīng)酯化保護(hù)羧基Mm一级黄色、保護(hù)氨基、保護(hù)羥基、硼氫化還原酯得醇超碰插插丝袜美女、Sn2取代和Mitsumobu反應(yīng)等合成巰基側(cè)鏈3日韩性交乱伦区；最后由化合物3經(jīng)脫保護(hù)、水解得硫醇国产亚洲欧美另类视频，和化合物2在二異丙基乙基胺的作用下縮合国产精品一线在线观看，最后Pd／C催化脫保護(hù)，歷經(jīng)16步反應(yīng)最終得到產(chǎn)物多尼培南三级Av中文字幕永久在线。

Second, using DBU as the base for enolization of propargylic esters of unsaturated acids 18e-k, we developed a tandem Ireland-Claisen rearrangement /isomerization reactions. It has been shown that the reaction sequence affords triene molecules 42a-b and 43a-b in moderated to high yields. Interestingly, with allyl hexa-3,5-dienoates 18i-j as the substrate, the rearranged products underwent further aromatization to give uniquely substituted benzyl acids 44a-b.

其次无码国产日韩精品一区，以含有活潑質(zhì)子的烯酸炔丙酯18e-k為底物，在DBU為烯醇化堿台湾性色HD性色AV、TMSCl為硅試劑的條件下污污亚洲视频视频，底物18e-h發(fā)生了Ireland-Claisen重排/異構(gòu)化串聯(lián)反應(yīng)，得到完全共軛的三烯類化合物42a-b及43a-b性在线视频网站；而以己二烯酸炔丙基酯18i-j為底物時(shí)欧美丰满熟妇xxxx性,，重排/異構(gòu)化后的產(chǎn)物進(jìn)一步發(fā)生電環(huán)化等反應(yīng)最終得到芳構(gòu)化產(chǎn)物——取代苯甲酸類化合物44a-b。

We researched on the prepartion of pivotal intermediate 2 and 3 for 1 P-methyl carbapenem antibiotics from intermediate 1, which is subjected to Reformastky reaction, N-alkylation, Dieckmann-type cyclisation, enolization, ester condensation etc. in sequence. The synthesis route of document is optimized by us.

我們研究了1β-甲基碳青霉烯類重要中間體的合成国外在线看的性视频网站，從中間體1出發(fā)經(jīng)Reformastky反應(yīng)狠狠久久噜噜老熟女、水解反應(yīng)合成出中間體2；經(jīng)Reformastky反應(yīng)自拍日韩美女视频网站在线观看免费、烷基化国产在线观看精品影院AV、Dieckmann環(huán)合、烯醇化亚洲一区二区三区偷拍、酯化合成出中間體3熟女屁眼，并對(duì)其中各步反應(yīng)作了優(yōu)化和探索。

The second synthetic strategy commenced from butane-1,4-diol 50, which underwent monobenzylation, Swern oxidation, enolization followed by acetylation and debenzylation to yield an intermediate 46 in an overall yield of 54% in a 4-step procedure.

第二條路線從1午夜在线观看国产剧情电影网，4-丁二醇50開始欧美黄色网站A，這個(gè)化合物經(jīng)過單芐基化、Swern氧化国产视屏大全、烯醇化隨后乙蹩纳侵蓿化和脫芐基化共4步反應(yīng)得到中間體46，總產(chǎn)率54％美女裸体黄18禁免费网站。

We studied DBU-mediated Ireland-Claisen rearrangement. Using DBU as the base for enolization of allylic esters of unsaturated acids 9-16, we found a novel DBU-mediated tandem Ireland-Claisen rearrangement /isomerization reactions and established a consecutive Ireland-Claisen rearrangement /Cope rearrangement.

利用DBU作為烯醇化堿av成人在线一区二区，對(duì)含有活潑質(zhì)子的烯酸烯丙酯類化合物9-16的Ireland-Claisen重排進(jìn)行了系統(tǒng)的研究，創(chuàng)建了一條新穎的DBU-促進(jìn)的Ireland-Claisen重排/異構(gòu)化串聯(lián)反應(yīng)及Ireland-Claisen重排/Cope重排的串聯(lián)反應(yīng)路線直接免费可以观看的黄色网站。

enolization：烯醇化

enolase 烯醇化酶 | enolization 烯醇化 | enolpyruvate phosphat 烯醇丙酮酸磷酸

enolization：烯醇化作用

enolase 烯醇酶;磷酸丙酮酸水合酶 | enolization 烯醇化(作用) | enologist 葡萄酒釀造者(工人、技師等)

enolization：烯醇化/烯醇化作用

enolizability /烯醇化程度/ | enolization /烯醇化/烯醇化作用/ | enology /葡萄酒釀造學(xué)/

enolization：縮醛交換

鹵烷基化 Transacetalation | 縮醛交換 Enolization | 烯醇化 Haloform reaction