From the early study of the pathogenesis of pre-eclampsia people have found its association with immunological function . In 1986 Ellis et al[1] had found that the extravillous chorionic cytotrophoblast contacting with the maternal tissue expressed high levels of Human leukocyte antigen-G, a major histocompatibility tissue-specific antigen . Extravillous chorionic cytotrophoblast with high levels expression of HLA-G proteins can invade the maternal deciduas and the maternal spiral arteries by displacing the endothelial lining and destroying most of the musculoelastic tissue of these arteries .

早期研究開始，許多學者即發(fā)現(xiàn)其與免疫學有密切關系精品一级黄色，至1986年Ellis等[1]發(fā)現(xiàn)人類白細胞抗原(human leukocyte antigen中国农村黄色网站av，HLA) G分子高度表達在絨毛外滋養(yǎng)層細胞( extravillous cytotrophoblast91精品国产自产在线观看高清，EVCT)上国产爽爽爽网，即浸潤至子宮蛻膜層甚至達子宮淺肌層以及子宮螺旋動脈內皮層青青青草网在线观看，與母血及子宮組織直接接觸的滋養(yǎng)細胞，這種獨特的組織分布提示HLA-G分子在母胎免疫耐受方面起重要作用伊人久久综合一区。