The 20S catalytic core of the 26S proteasome has the shape of a barrel made of four rings which are composed of seven differentαsubunitsα_1-α_7 at two outer rings and seven differentβsubunitsβ_1-β_7 at two inner rings at which the catalytic sites locate. Three of theβsubunits contain proteolyses sites, which are sequestered in the hollow interior of the 20S particle. Substrates enter the 20S through a narrow channel formed by theβsubunits, whose N-termini, depending on their conformation, can either obstruct or allow substrate entry and thus function as a gate. This entry channel is narrow and only permits passage of unfolded, linearized polypeptides.

哺乳動(dòng)物26S蛋白酶體是由一個(gè)20S催化顆粒(catalytic particle，CP)和兩個(gè)19S調(diào)節(jié)顆粒(regulatory particle免费视频久久久，RP)組成的ATP(adenosine-triphosphate，ATP)依賴性蛋白水解酶復(fù)合體。20S CP是26S蛋白酶體的催化核心国家a级黄片，它是由4個(gè)圓環(huán)堆疊形成的桶狀復(fù)合物，其中兩側(cè)外環(huán)每個(gè)環(huán)是由α_1-α_7亞基組成国产淫荡妇女av，兩個(gè)內(nèi)環(huán)每個(gè)環(huán)是由β_1-β_7亞基組成国产美女网在线看，4個(gè)環(huán)的中央形成一個(gè)狹窄的內(nèi)腔。2個(gè)β內(nèi)環(huán)形成了20S CP的催化中心空腔www18禁，其內(nèi)壁為催化活性位點(diǎn)所在地成年女人vr免费视频播放；外側(cè)α環(huán)中心的孔道是底物到達(dá)催化中心空腔的通道，一般被α亞基上的N末端所封閉亚洲h成视频，阻止胞內(nèi)非目的靶蛋白進(jìn)入20S CP內(nèi)被降解破壞小草A片。

Under the same experimental condition, boiling heat transfer of nitrogen in lunate narrow channel performs better than that in circular narrow channel.

弦月形通道與環(huán)縫通道相比，在相同的條件下岛国毛片久久69，弦月形通道顯示出更好的換熱效果XⅩXWWW。

Based on the analysis of physics course of heat transfer, the mathematical model of single-phase flow in the rectangular narrow channel is proposed. And the boundary conditions are given to get the unique numerical result. The finite volume method is used to found the discrete scheme of equations. According to the flow of SIMPLER arithmetic, the computing program is developed and the correctness of program is validated.Then the program is used to solve the problem of flow and heat transfer in rectangular narrow channel.The stable two dimension velocity and temperature fields in rectangular narrow channel and plate fuel are obtained.

在明確窄縫流道及燃料板換熱物理過程的基礎(chǔ)上，建立了描述矩形窄縫內(nèi)單相流動(dòng)與換熱問題的數(shù)學(xué)模型最新黄色网站一级，并給出了合理的邊值條件亚洲自拍第一区；然后利用有限容積法對(duì)方程進(jìn)行離散，根據(jù)SIMPLER算法的流程編制了模型求解程序日韩欧美亚中州在线观看；在驗(yàn)證程序正確性的基礎(chǔ)上日本三级在线专区高清，對(duì)矩形窄縫流動(dòng)與換熱問題進(jìn)行了求解，得到了矩形窄縫流道和板狀燃料元件內(nèi)部溫度場(chǎng)国产美女AAA在线、速度場(chǎng)的二維分布九九视频精品38在线播放。

narrow band spectrum：狹(帶)頻譜

narrow-band pulse 窄帶脈動(dòng) | narrow-band spectrum 狹(帶)頻譜 | natural channel 天然河槽

narrow band：窄帶法

窄環(huán)隙:Narrow annuli | 窄帶法:narrow band | 窄流道:Narrow Channel

Narrow annuli：窄環(huán)隙

狹水道:Narrow channel | 窄環(huán)隙:Narrow annuli | 窄帶法:narrow band