Meanwhile,HDAC1 acetylation level is significantly increased.The overexpression of HDAC1 can promote erythroid cell proliferation and inhibits induced differentiation,the knockdown of HDAC1 or 2 inhibits erythroid cell proliferation and promotes induced differentiation.We also found that HDAC1 affects GATA1 mediated transcription activity.Thus our data revealed that HDAC1 may negatively regulate GATA1 mediated transcription and suggest that the dynamic regulation of GATA1 associated NuRD/MeCP1/HDAC1/HDAC2 complex may determine the onset of erythroid differentiation programs.Moreover,this study will eventually help to design new therapeutic approaches in treatment of leukemia.

研究發(fā)現(xiàn)在被誘導分化的小鼠紅細胞白血病細胞中與GATA1相結合的HDAC1被乙酰化并失去活性中文字幕第22页，在血細胞中過表達HDAC1能夠促進血細胞的增殖并抑制分化seyoyo在线观看，反之在血細胞中敲除HDAC1或HDAC2能抑制血紅細胞的增殖并促進分化，而且HDAC1能夠負調控GATA1的轉錄活性午夜免费电影网，GATA1與NuRD/MeCP1復合體之間的動態(tài)調控国产一级性爱免费视频，決定血紅細胞分化的發(fā)生和發(fā)展，并為探索白血病的致病機理奠定了理論基礎。

nurd：abbr. non-uniform rotational distortion; 不均勻旋轉扭曲