These solutions will produce in-situ gel formation when transmitted from non-physiological to physiological condition. These polymer systems once instilled in the cul-de-sac will prolong the precorneal resistance time and increase the ocular bioavailability of drugs.

這些溶液由非生理狀態(tài)轉(zhuǎn)變成生理狀態(tài)時(shí)會(huì)產(chǎn)生原位成膠(In-situ gel formation)，因此一旦滴入眼睛穹窿內(nèi)日韩激情无码一区二区三区91，可延長藥劑在前角膜的滯流時(shí)間及強(qiáng)化其眼的生體可用率。

The commercialized liquid ophthalmic formulation is eliminate from the precorneal area immediately upon instillation because of lacrimal secretion and nasolacrimal drainage. This results in very low ocular bioavailability. The problem can be conqurered by in situ gelling system for ophthalmic drug delivery.

一般市面用液體眼藥制劑常因滴入眼睛時(shí)，受到經(jīng)常性的淚液分泌及鼻淚管的快速排液91夜色精品国产网站，因此呈現(xiàn)很低的生體可用率，此缺點(diǎn)可用原位成膠(In-site gel formation)輸送系統(tǒng)來加以改善精品麻豆国产免费一区二区三区。

Theshese sole:olutiollns will produce In-situ gel formation when transmltted Tcl from non-physiologlcal to physiologlcal condition. These polymer systems once instilled In the cul-de-sac WIII prolong the precorneal reslstance time and Increase the ocular bloavallabillty of drugs.

這些溶液由非生理狀態(tài)轉(zhuǎn)變成生理狀態(tài)時(shí)會(huì)產(chǎn)生原位成膠(In-stiu gel forma-tion)国产精品一级毛片www，因此一旦滴入眼睛穹窿內(nèi)，可延長藥劑在前角膜的滯留時(shí)間及強(qiáng)化其眼的生體可用率久久艹综合网。

precorneal residence：角膜滯留

屬地征收:residence-specific collection | 角膜滯留:precorneal residence | 商品住宅:commodity residence

precorneal tear film：角膜前淚液膜

角膜營養(yǎng)不良 corneal dystrophy | 角膜前淚液膜 precorneal tear film | 角膜脂肪變性 fatty degeneration of cornea