In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

綜合全部實(shí)驗(yàn)結(jié)果能看的黄色网站福利，本研究提示：夏季和低齡是托吡酯引起泌汗障礙的主要危險(xiǎn)因素99热这里只有精品7，而托吡酯劑量對(duì)泌汗功能的影響較型军S色毛片⊙侵抟患缎越换破煌羞刘タ梢砸种菩∈蠛挂旱姆置冢∈蟮哪挲g并不影響這種抑制作用不卡一区二区在线观看免费，但托吡酯對(duì)小鼠體溫?zé)o明顯影響高清一区二区三区免费杂交；托吡酯并不是通過(guò)對(duì)GABAA受體及AMPA和KA兩種谷氨酸受體亞型的作用而在汗腺分泌細(xì)胞抑制泌汗人妻丝袜av先锋影音先锋；托吡酯不影響汗腺形態(tài)及Na国产精品一区白拍免费看，K-ATP酶活性；汗腺分泌細(xì)胞的AQP5功能失調(diào)可能與托吡酯引起的泌汗障礙密切相關(guān)欧美性爱亚洲有码，而碳酸酐酶抑制作用并不是泌汗功能損害的主要原因国产熟女对白免费播放。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

綜合全部實(shí)驗(yàn)結(jié)果，本研究提示：夏季和低齡是托吡酯引起泌汗障礙的主要危險(xiǎn)因素日韩毛片中文字幕免费看，而托吡酯劑量對(duì)泌汗(來(lái)源：A44B8787C論文網(wǎng)www.abclunwen.com)功能的影響較性谙咭患妒只悠怠；托吡酯可以抑制小鼠汗液的分泌日本3级黄色视频，小鼠的年齡并不影響這種抑制作用www.ahrwzdm.com，但托吡酯對(duì)小鼠體溫?zé)o明顯影響；托吡酯并不是通過(guò)對(duì)GABAA受體及AMPA和KA兩種谷氨酸受體亞型的作用而在汗腺分泌細(xì)胞抑制泌汗99视频久久久久；托吡酯不影響汗腺形態(tài)及Na天堂网在线WWW中文，K-ATP酶活性；汗腺分泌細(xì)胞的AQP5功能失調(diào)可能與托吡酯引起的泌汗障礙密切相關(guān)日韩一级黄色录像影片夫妻性生活影片，而碳酸酐酶抑制作用并不是泌汗功能損害的主要原因一级黄手机免费在线视频。

And, they are greatly found in special secretory glands or cells within the plant life.

并發(fā)現(xiàn)他們十分特殊腺體分泌或植物細(xì)胞內(nèi)的生命。