OBJECTIVE To design and develop a clinical pharmacokinetics and individual drug dosage regimens system CPKDP program for estimating individual pharmacokinetic parameters and optimizing individualizing dosage regimens using routine clinical data of plasma levels. METHODS According to the principle of population pharmacokinetics and Bayes" formula, CPKDP program was written with FOXPRO 2.6 and BORLAND C++ 3.1, and was run on 486 microcomputer with UCDOS 5.0. RESULTS CPKDP program was adapted for drugs with different characteristics of pharmacokinetics, and for single dose or multiple dose administration. Using 1 or 2 measured drug concentrations, individual patient"s pharmacokinetic parameters were estimated based on population-average pharm-acokinetic parameters. CONCLUSION CPKDP program is applied for estimating pharmacokinetic parameters and optimizing drug therapy in individual patients.

目的為利用臨床常規(guī)監(jiān)測的血藥濃度數(shù)據(jù)估算病人的個(gè)體藥動(dòng)學(xué)參數(shù)午夜影院视频，優(yōu)化給藥方案国产麻豆乱伦性爱视频，設(shè)計(jì)九九C片一级黄片、研制了臨床藥動(dòng)學(xué)給藥個(gè)體化系統(tǒng)CPKDP程序方法依據(jù)群體藥動(dòng)學(xué)原理及Bayes公式日韩第一页在线导航页，CPKDP程序用FOXPRO 2.6和BORLAND C++ 3.1開發(fā)日韩区欧美区，在希望漢字系統(tǒng)UCDOS 5.0平臺(tái)上運(yùn)行結(jié)果CPKDP程序適用于具有不同藥動(dòng)學(xué)特征的多種藥物欧美资源自慰，適用于不同給藥途徑的單劑量或多劑量給藥在群體藥動(dòng)學(xué)參數(shù)的基礎(chǔ)上，結(jié)合病人個(gè)體特征国产又粗又长又大又色，以12020国内偷拍，2個(gè)血藥濃度作為反饋，即可擬合估算個(gè)體藥動(dòng)學(xué)參數(shù)狼友日韩三级，優(yōu)化給藥方案結(jié)論經(jīng)初步應(yīng)用久久性网，CPKDP程序是應(yīng)用Bayes反饋法開展臨床個(gè)體化給藥工作非常實(shí)用的工具

Methods and Results— Using a micro–single-photon emission computed tomography small-animal imaging system and a Food and Drug Administration–approved radiotracer ([indium 111] oxyquinoline, 111In-oxine), we demonstrate here that monocyte recruitment to atherosclerotic lesions can be visualized in a noninvasive, dynamic, and 3-dimensional fashion in live animals.

方法和結(jié)果——采用微單光子發(fā)射計(jì)算機(jī)斷層攝影術(shù)的小動(dòng)物成像系統(tǒng)和美國食品藥品治理局認(rèn)同的放射性示蹤劑（111In-oxine），我們證實(shí)動(dòng)物體內(nèi)單核細(xì)胞向動(dòng)脈粥樣硬化損害處的聚集能夠通過一種非侵入性欧美精品亚洲精品日韩传电影，動(dòng)態(tài)的老女人性生活视频，3維方式進(jìn)行可視化觀察。

Methods and Results-Using a micro-single-photon emission computed tomography small-animal imaging system and a Food and Drug Administration-approved radiotracer [indium 111] oxyquinoline,(111In-oxine, we demonstrate here that monocyte recruitment to atherosclerotic lesions can be visualized in a noninvasive, dynamic, and 3-dimensional fashion in live animals.

方法和結(jié)果：我們通過Micro-SPECT小動(dòng)物顯像系統(tǒng)和FDA批準(zhǔn)的示蹤劑（銦111-羥化喹啉）天堂av.com，證實(shí)單核細(xì)胞向AS病變處募集過程可以被非侵入性影像技術(shù)動(dòng)態(tài)欧美视频a、三維模式觀察到。