Methods Starting from 2-chloro-4-nitrophenol and 2- pyridine hydrochlorid, 3-chloro-4-(pyridin-2-ylmethoxy) aniline was obtained via etherization and reduction. The obtained aniline coupled with N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) acetamide to give 4-[3-chloro-4-(2-pyridylmethoxy) phenylamino]-3-cyano-7-ethoxy-6-N-acetylaminoquinoline. And then it was deacetylated, followed by reacting with4- but-2-enoyl chloride to yield the target compound neratinib.

以2-氯－4-硝基苯酚和2-氯甲基吡啶為起始原料，經(jīng)醚化新怡红院在线视频永久、硝基還原得到3-氯－4-（吡啶－2-甲氧基）苯胺亚洲中文精品图区，3-氯－4-（吡啶－2-甲氧基）苯胺與3-氰基－6-乙酰氨基－7-乙氧基－4-氯喹啉反應(yīng)得到3-氰基－6-乙酰氨基－4-［3-氯－4-（吡啶－2-甲氧基）苯氨基］－7-乙氧基喹啉，3-氰基－6-乙酰氨基－4-［3-氯－4-（吡啶－2-甲氧基）苯氨基］－7-乙氧基喹啉去乙酰保護(hù)基后日韩经典国内精品视频在线观看免费，與-4-二甲氨基－2-丁烯酰氯經(jīng)?38免费在线视频精彩观看；磻?yīng)得到ner-atinib。

A selective and mild PS-DIB/ionic-liquid immobilized 2, 2, 6, 6-tetramethyl-piperidin-4-ol-N-oxyl catalytic oxidation procedure of alcohols to the corresponding aldehydes and ketones in ionic liquid BF4 at room temperature was developed. The oxidant PS-DIB was prepared via the iodation and acetylation of polystyrene resin. For the preparation of the ionic-liquid immobilized TeMPO catalyst, 4-(2, 2, 6, 6-Tetramethyl-1-oxyl-4-piperidoxyl)butyl bromide was first synthesized from TeMPO and 1, 4-dibromobutane.

將聚苯乙烯樹脂先碘化再乙醪俦泼悠凳钥?5分钟；埔低久夥言谙吖劭矗频昧素?fù)載型二乙酰氧碘苯作為氧化劑。2五级黄18以上欧美片， 2人人做人人爽国产视， 6， 6-四甲基－N-氧自由基哌啶醇與1成人漫画在线， 4-二溴丁烷反應(yīng)生成4-溴丁氧基－2国产精品三区视频， 2， 6女的被男的C出水来免费视频， 6-四甲基－哌啶－1-氧化物欧美福利x，再與N-甲基咪唑發(fā)生季銨化反應(yīng)毛片免费全部播放无码直播，生成的溴化季銨鹽與四氟硼酸鈉進(jìn)行離子交換制得氟硼酸型2， 2美女被操在线， 6欧美理论大片清免费观看， 6-四甲基－N-氧自由基哌啶負(fù)載離子液體。

A selective and mild PS-DIB/ionic-liquid immobilized TEMPO catalytic oxidation procedure of alcohols to the corresponding aldehydes and ketones in ionic liquid BF4 at room temperature was developed. The oxidant PS-DIB was prepared via Iodation and acetylation of polystyrene resin. For the preparation of the ionic-liquid immobilized TEMPO catalyst, 4-(2,2,6,6-Tetramethyl-1-oxyl-4-piperidoxyl)butyl bromide was first synthesized from 2,2,6,6-tetramethyl-piperidin-4-ol-N-oxyl and 1,4-dibromobutane.

將聚苯乙烯樹脂先碘化再乙蹙肪镁弥蘧镁镁镁茫基化国产精品ⅴa无码一区二区，制得了負(fù)載型二乙酰氧碘苯(diacetoxyiodo polystyrene，PS-DIB)作為氧化劑1024无码中文。2人人爽人人爽人人COm，2，6欧美操屄视频在线播放，6-四甲基-N-氧自由基哌啶醇(2无码免费毛片毛机在线ww，2，6人妻啪啪视频，6-tetramethyl-piperidin-4-ol-N-oxyl黄色在线专区，TEMPO)與1，4-二溴丁烷反應(yīng)生成4-溴丁氧基-2人人操人人操人人操人人爽，2国产精彩小视频，6，6-四甲基-哌啶-1-氧化物欧美一级a大黄片，再與N-甲基咪唑發(fā)生季銨化反應(yīng)国产永久亚洲18禁在线，生成的溴化季銨鹽與四氟硼酸鈉進(jìn)行離子交換制得氟硼酸型2，2一级性生活强奸免费不卡视频，691视频网站入口，6-四甲基-N-氧自由基哌啶負(fù)載離子液體TEMPO-IL。

The synthesis of nalbuphine hydrochloride from thebaine as starting material was through following processes:oxidation,high-pressure hydrogenation,acetylation,removing methyl of 3-methoxy,hydrolysis,condensation,reduction and finial salification.

以蒂巴因?yàn)槠鹗荚厦琅闾灞徊偻久夥眩?jīng)氧化se色综合w、高壓氫化、乙跻寥送谙呙夥眩化欧洲一级电影免费播放视频、氰化、脫3-位甲氧基的甲基久久精品精品久久、水解wwww黄色网站、縮合、還原久久精品国产亚洲一区二区东京热、成鹽欧美老妇女性爱网站，合成了鹽酸納布啡，總收率達(dá)18男人的天堂最新网址。

Ethoxycarbonyl-4,5-dimethyl-pyrrole (7) was prepared from ethylacetoacetate, ethyl formate and methyl ethyl ketone via oximination, Claisen condensation, and reductive condensation. The bromization of compound 7 gave 2-ethoxycarbonyl-3-bromo-4,5-dimethyl-pyrrole(8), which could be transferred to 2-ethoxy-carbonyl-3-brome-4-methyl-5-formyl-pyrrole (9) by the formolation.

由乙酰乙酸乙酯人人上人人操超碰、甲酸乙酯及丁酮等原料經(jīng)過肟化、Claisen縮合亚欧综合在线、還原縮合成環(huán)得到2-乙氧羰基－4欧美乱交牲交乱频，5-二甲基－吡咯(7)，溴化生成2-乙氧羰基－3-溴4超薄丝袜脚交足免费播放，5-二甲基－吡咯(8)国产拍精品，最后經(jīng)過甲酰化反應(yīng)得到目標(biāo)產(chǎn)物2-乙氧羰基－3-溴－4-甲基－5-甲醣涮蘸帜晃蘼胧悠迪略兀基－吡咯(9)人人摸日日干。

Ib was synthesized by condensation of phthalic anhydride with 2-methylresorcinol in fused AlCl〓/NaCl (5∶1), followed by selective acetylation, methylation, NBS bromination and condensation with sodium ethoxide.

鄰苯二甲酸酐在熔融的三氯化鋁-氯化鈉(5：1)中和-2，6-二羥基甲苯環(huán)合得1欧美日韩精品一区二区91，3-二羥基-2-甲基蒽醌〓后經(jīng)選擇性乙豕夥岩患抖禔V；⒓谆粕⊥尽BS溴化www.白白色、乙醇鈉縮合得1-甲氧基-2-乙氧甲基-3-羥基蒽醌。

The first synthetic route uses 1,2,4-trimethoxybenzene and chloroacetonitrile in forming 2,4,5-trimethoxy-a-chlor-acetophenone under the anhydrous condition, then the intermediate condensates with papaverine forming the core pyrro[2,l-a]isoquinoline, followed by formation and lactonization to form the lactone ring. The second synthetic route uses prepared aldehyde with prepared ethyl nitroacetate by Knoevenagel condensation to obtain 2-Nitro-3-(2,4,5-tris-methoxy-phenyl)-acrylic acid ethyl ester and 2-Nitro-3-(2,4,5-tris-benzyloxy -phenyl)-acrylic acid ethyl ester etal intermediates. The lamellarin skeleton could arise from condensation of the papaverine and these intermediates by Michael reaction, the ester group is provided for subsequent lactonization. The third synthetic route uses coumarin or indan-l,3-dione derivatives and papaverine to form lamellarin under basic conditions.

第一條路線首先從1性爱av一区二区三区，2精品国产亚洲污黄网站在线观看，4-三甲氧基苯出發(fā)與鹵乙腈作用合成鹵代芳酮中間體，然后與罌粟堿反應(yīng)合成開鏈片螺素久久久久精品国产三级，最后經(jīng)乙豕诰肺缫估砺郏化、去保護(hù)亚州日韩制服丝袜图片、成內(nèi)酯環(huán)得到片螺素毛片激情片免费看；第二條路線由制備的芳醛和制備的硝基乙酸乙酯經(jīng)縮合得到2-硝基-3-芳基丙烯酸乙酯，然后由該中間體與罌粟堿反應(yīng)国产亚洲无线一区二区，在完成關(guān)環(huán)的同時(shí)也引入酯基欧美午夜艳，最后去保護(hù)、成內(nèi)酯環(huán)得到片螺素国产午夜福利在线播放92；第三條路線是由香豆素或茚二酮出發(fā)亚洲三级片视频，經(jīng)溴代后的中間體與罌粟堿反應(yīng)，得到片螺素的基本框架无码一级毛片免费。

The famciclovir was synthesized from purine by a series of steps by Acylation, Decarboxylation, Reduction ,and so on; Derivatives of these intermediates is described from the 6-chloro- 9H- purin-2-amine as raw materials in different conditions when the iodine and bromide were synthesized with the addition of two intermediate 6-bromo-9H-purin-2-amine and 6-iodo-9H-purin-2-amine; There is elaborated from the main part of a acetophenone, urineaminohydrochloride, phenylhydrazine, ethyl acetoacetate as raw material through a series of reactions to synthetic 3-phenyl-4-formylphenyl pyrazole and 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-aldehyde two pyrazole aldehyde, and then with 2-amino-6-chlorine-9-(2-methicillin-oxo-co-methyl-4-yl) purine reaction of the two new pyrazole purine Schiff bases.

本論文主是采用以鳥嘌呤為原料一区二区强奸，經(jīng)過一系列的酰基化97干视频，脫羧欧美一级俄罗斯a片，還原等反應(yīng)作用下最終得到了產(chǎn)物2-氨基-9-(4-乙酰氧基-3-乙酰氧基甲基丁基)嘌呤；其中的中間體衍生物主要是闡述從以2-氨基-6-氯鳥嘌呤為原料通過在不同的條件下進(jìn)行溴代與碘代分別合成了另外兩種中間體2-氨基-6-溴鳥嘌呤及2-氨基-6-碘鳥嘌呤欧美色图亚洲；還有一部分主要是闡述從以苯乙酮综合sese，鹽酸氨基脲国产熟女精品视频500，苯肼，乙酰乙酸乙酯為原料通過一系列的反應(yīng)先合成3-苯基-4-醛基吡唑及5-氯-3-甲基-1-苯基-1H-吡唑-4-甲醛這兩個(gè)吡唑醛国产欧美性爱大黄片，然后再與2-氨基-6-氯-9-(2-甲氧羰基丁酸甲酯-4-基)嘌呤反應(yīng)得到了兩個(gè)新型的吡唑嘌呤席夫堿

Respectively, glutamic acid derivatized β-CD has been synthesized with epoxy chloropropane as the intermediate, a water-insoluble yellow liquid was got after the acetylating of the by using acetic anhydride, which was used as a novel gas chromatographic CSP; A water-soluble β-CD polymer cross-linked with epoxy chloropropane has been synthesized, and the derivatives of β-CD polymer were synthesized by its alkylating and acetylating. The different β-CD derivatives were coated on silica capillary columns by dynamic method, the chromatographic properties and retention behaviors of the fused silica capillary columns were studied, the results showed that the β-CD derivatives had good stereoselectivity and separation results to some compounds, especially to various positional isomers and enantiomers.

本文還分別以環(huán)氧氯丙烷為中間體影音先锋AV资源网日韩在，合成了七{2，6-二-O-[3-(1在线精品AⅤ视频一区二区，3-二羥基丙氨酸)]}-β-環(huán)糊精高清国产黄片，再用醋酸酐將其乙酰化91第四色国产在线视频，得到了一種淡黃色粘稠液體性动态图免费视频专区，合成了一種新型的環(huán)糊精衍生物；以環(huán)氧氯丙烷作交聯(lián)劑合成了一種水溶性的β-環(huán)糊精聚合物亚洲无码乱伦精品，再將其烷基化和趸粕悠堤丶禷视频免费看；铣闪甩?環(huán)糊精聚合物的不同衍生物亚洲a级毛片电影，用動(dòng)態(tài)法將不同類型的β-環(huán)糊精衍生物涂漬在石英毛細(xì)管柱上18未成禁片一级毛片喷水，通過對(duì)所制備柱柱性能的測試和對(duì)一系列化合物的分離和保留行為的研究，結(jié)果表明所合成的β-環(huán)糊精衍生物對(duì)各類化合物欧美午夜性，特別是對(duì)位置異構(gòu)體和對(duì)映異構(gòu)體具有較好的分離效果免费视频在线观看4444，顯示了很強(qiáng)的立體選擇性。

Bezaldehyde was used as protective agent in first method.S-Epichloeohydrin was aminated and acidulated to give(2S)-1-Amino-3-chloro-propanol Salts.The acetylation of (2S)-1-Amino-3-chloro-propanol by acetic anhydride produced the intermediate-N-[2--3-chloropropyl]acetamide.And then at 20℃,in the presence of lithium tert-butoxide,benzyl 3-fluoro-4-morpholinophenyl carbamate react with-N-[2--3-chloropropyl]acetamide to give linezolid in total yield of 43.6%.

路線一采用苯甲醛作保護(hù)劑狠狠看香港澳门黄色片视频，使S-環(huán)氧氯丙烷氨解日韩精品人妻系列视频在线、酸化生成S-1-氨基-3-氯-2-丙醇鹽酸鹽，然后經(jīng)乙魽级免费黄片；磻?yīng)后亚洲日韩精品久久久久，生成中間體-N-[2-乙酰氧基-3-氯丙基]乙酰胺，再用N-(3-氟-4-嗎啉苯基)氨基甲酸芐酯和中間體在催化劑叔丁醇鋰存在下25℃反應(yīng)生成利奈唑酮国产日韩在线亚洲色视频，總產(chǎn)率達(dá)到43.6%不满18岁进入黄色网站。

acetum：醋劑

acetoxylation 乙酰氧基化 | acetum 醋劑 | acetyl 乙酰

acetum：醋 醋劑

acetoxylation /乙酰氧基化/ | acetum /醋/醋劑/ | acetyl /乙酰/乙踉谙哐侵廾夥眩基/

melissa officinalis：香蜂花

月桂基硫酸銨,乙二醇二硬脂酸酯,二(氫化牛脂基)鄰苯二甲酸酰胺,聚二甲基硅氧烷醇,椰油酰兩性基乙酸鈉,吡羅克酮憶醇胺鹽,二棕櫚酰氧乙基二甲基氯化銨,香精,蓖麻油基馬來酸酯類,月桂基二甲基銨羥丙基小麥蛋白,DMDM乙內(nèi)酰脲,香蜂花(MELISSA OFFICINALIS)提取物,紅松(PI

occipital：枕部的, 枕骨的 枕骨

hydrencephalocele 積水性腦突出 | occipital 枕部的, 枕骨的 枕骨 | acetyhydroperoxide 乙踉谙呔费侵抟磺笊瘢化過氧氫 過醋酸

acetic peracid：[化] 過乙酸; 過醋酸

1178acetic hydroperoxide[機(jī)] 乙酰化過氧氫, 過醋酸 | 1179acetic oxide[化] 乙酐; 乙酸酐; 氧化乙酰 | 1180acetic peracid[化] 過乙酸; 過醋酸

Synthetic Rubber SBR：合成橡膠

氟化鈉 sodium fluoride | 合成橡膠 Synthetic Rubber SBR 1502 | 3-氨基-4-甲氧基乙酰苯胺 3-AMINO 4-METHOXY ACETANILIDE

acetoxyl group：乙酰氧基

acetoxime 丙酮肟 | acetoxyl group 乙酰氧基 | acetoxylation 乙酸化

acetylperoxide：乙跹侵尥计访佬∷担化過氧

acetyloxyphenol | 乙酸雷瑣辛, 間苯二酚一乙酸酯 | acetylperoxide | 乙跞巳瞬偃巳怂粕化過氧 | acetylphenol | 乙酰苯酚

acetylphenol：乙酰苯酚

acetylperoxide | 乙酰化過氧 | acetylphenol | 乙酰苯酚 | acetylphenyl salicylate | 乙酰水楊酸苯酯

acetyl oxide：乙酰化氧,乙(酸)酐

acetyl number || 乙酰值 | acetyl oxide || 乙跄腥伺嗣土椅拚诘裁夥咽悠担化氧, 乙(酸)酐 | acetyl phosphate || 乙酰磷酸