Then Doripenem came into the market in the July ,2005. We studied the synthesis of Doripemen.Firstly, we synthesized the chemical 2 from the starting material------o-hydroxylphenylacylamine through Reformastky reaction, alkylation, Diekmann reaction, enolization, esterification and etc. Secondly, we synthesized the chemical 3 from L — hydroxylproline through the protection of carboxyl, amidogen and hydroxyl group, reduction by NaBr, SN_2 substitution and Mitsumobu reaction.

我們以水楊酰胺為起始原料国产亚洲91在线，經Reformatsky反應人人摸人人草人人操、烷基化色爱爱亚洲视频综合、Diekmann環(huán)合、烯醇化18禁片免费网站在线看、酯化等反應合成雙環(huán)母核2亚洲欧美一区二区欧美亚洲A；再從L-羥基脯氨酸出發(fā)，經酯化保護羧基免费看国产黄A片在线、保護氨基精品欧美日韩一区二区麻豆91、保護羥基、硼氫化還原酯得醇在线国产黄色站、Sn2取代和Mitsumobu反應等合成巰基側鏈3色哟脚在线观看视频；最后由化合物3經脫保護、水解得硫醇东北粗口熟女丰满高潮，和化合物2在二異丙基乙基胺的作用下縮合网友自拍偷拍一区，最后Pd／C催化脫保護，歷經16步反應最終得到產物多尼培南午夜激情黄网。

It was shownthat, among the three possible tautomers; i.e., the keto-form and the two enol forms, and thecorresponding enol anion, only the enol form 31 was actually responsible for the singletoxygen reactions.

用核磁共振及從頭算法研究了化合物12b和23a在甲醇和吡啶中的烯醇化作用精品国产AV片儿，結果表明，在其三種互變異構體以及相應烯醇負離子中51国产黄色视频，只有烯醇式31是實際參與單重態(tài)氧反應的成份轻点好疼好大好爽视频网站。

Phosphoglycerate is converted to 2-phosphoglycerate by phosphoglycerate mutase.

2-磷酸甘油酸在烯醇化酶的催化下生成磷酸烯醇式丙酮酸。

From the femur bone density analysis of protein expression, we can see that light chain lactoferrin, annexin decreased and the expression of enolase, ATP synthase, acetyl-coenzyme A reductase, the expression of troponin, may be related to ovariectomized femoral bone density in osteoporosis-related happened; strong bone of the femoral osteoporosis Po intervention effect may be related to reduced enolase, ATP synthase, troponin, CK-MB, acetyl phosphoglycerate enzyme, the expression of myosin, and the increase in lactoferrin light chain, pyruvate kinase isoenzyme, protein expression crown.

從股骨密質骨蛋白質組表達分析可知，乳鐵蛋白輕鏈、膜聯蛋白A3的表達下降及烯醇化酶亚洲欧美人成人综合在线播放、ATP合酶在线视频伦、乙酰輔酶A還原酶、肌鈣蛋白的表達增強18禁网站网址，可能與去卵巢后股骨密質骨骨質疏松的發(fā)生相關15yc午夜福利在线视频；強骨寶對股骨骨質疏松的干預效應可能與下調烯醇化酶操美女视频网站、ATP合酶、肌鈣蛋白色拍拍网、肌酸激酶同工酶国产性爱专区、磷酸甘油酸變味酶、肌球蛋白的表達一级一片免费观看，和上調乳鐵蛋白輕鏈成年人的福利、丙酮酸激酶同工酶、冠蛋白的表達有關欧美十日韩十国产。

Cancellous bone from the lumbar proteomic expression analysis show that actin, keratin, enolase, ATP synthase, the expression of myosin may be related to ovarian lumbar cancellous bone after osteoporosis-related happened; Qiang Gu Bao Po on the lumbar spine osteoporosis intervention effect may be related to reduced carbonic anhydrase, actin, crystal protein, 3- phosphoglycerate dehydrogenase, serum albumin, ATP synthase, myosin, the enolase expression.

從腰椎松質骨蛋白質組表達分析可知在线观看无码国产剧情AV，肌動蛋白、角蛋白99这里只有精品首页、烯醇化酶国产尤物第一区第二区精品、ATP合酶、肌球蛋白的表達增強可能與去卵巢后腰椎松質骨骨質疏松的發(fā)生相關青草视频在线播放精品无码；強骨寶對腰椎骨質疏松的干預效應可能與下調碳酸酐酶一级A片少妇免费、肌動蛋白、αB-晶體蛋白91人妻教师超碰、3-磷酸甘油醛脫氫酶绿帽人妻91社区、血清白蛋白、ATP合酶最新午夜国内自拍视频、肌球蛋白黄色超碰在线观看、烯醇化酶的表達有關。

Second, using DBU as the base for enolization of propargylic esters of unsaturated acids 18e-k, we developed a tandem Ireland-Claisen rearrangement /isomerization reactions. It has been shown that the reaction sequence affords triene molecules 42a-b and 43a-b in moderated to high yields. Interestingly, with allyl hexa-3,5-dienoates 18i-j as the substrate, the rearranged products underwent further aromatization to give uniquely substituted benzyl acids 44a-b.

其次91在线视频网站首页，以含有活潑質子的烯酸炔丙酯18e-k為底物在线a视频48saocom，在DBU為烯醇化堿、TMSCl為硅試劑的條件下AV网站天堂网，底物18e-h發(fā)生了Ireland-Claisen重排/異構化串聯反應精品伊人久久大线蕉色首页，得到完全共軛的三烯類化合物42a-b及43a-b；而以己二烯酸炔丙基酯18i-j為底物時99超碰在线播放，重排/異構化后的產物進一步發(fā)生電環(huán)化等反應最終得到芳構化產物——取代苯甲酸類化合物44a-b日韩特黄一区二区。

We researched on the prepartion of pivotal intermediate 2 and 3 for 1 P-methyl carbapenem antibiotics from intermediate 1, which is subjected to Reformastky reaction, N-alkylation, Dieckmann-type cyclisation, enolization, ester condensation etc. in sequence. The synthesis route of document is optimized by us.

我們研究了1β-甲基碳青霉烯類重要中間體的合成，從中間體1出發(fā)經Reformastky反應欧美日韩在线日韩欧美、水解反應合成出中間體2卡通伦欧美有码亚洲；經Reformastky反應、烷基化免费视频日韩、Dieckmann環(huán)合人人摸人人人人操人人、烯醇化、酯化合成出中間體3国产丰满熟女视频，并對其中各步反應作了優(yōu)化和探索A片黄片视頻。

We studied DBU-mediated Ireland-Claisen rearrangement. Using DBU as the base for enolization of allylic esters of unsaturated acids 9-16, we found a novel DBU-mediated tandem Ireland-Claisen rearrangement /isomerization reactions and established a consecutive Ireland-Claisen rearrangement /Cope rearrangement.

利用DBU作為烯醇化堿www.久久精品视频.com，對含有活潑質子的烯酸烯丙酯類化合物9-16的Ireland-Claisen重排進行了系統(tǒng)的研究，創(chuàng)建了一條新穎的DBU-促進的Ireland-Claisen重排/異構化串聯反應及Ireland-Claisen重排/Cope重排的串聯反應路線色悠久久久综合网。

Other methyl nucleophiles includingMeMgBr, MeCeCl2, MeTiCl3, Me3Al, Me3ZnMgCl, MeMnClwere tried, but in all these cases no detectable amount of exo-C8-methylated product was obtained. Although protecting C3-carbonyl as 1,3-dioxolanes could be achieved, the serious enolization of C8-carbonyl was still problematic. Converting C9-furan ring to α,β-butenolide did depress the enolization, but desired C8-methylation was completely replaced by migration of the double bond of the butenolide.

在本論文的早期階段国产欧美日韩精品有声小说，主要著眼于解決二環(huán)[3.2.1]-C8-羰基加成甲基所遇到的C9-呋喃環(huán)差向異構化和C3與C8兩個羰基之間化學選擇性的問題：通過引入不同金屬降低甲基試劑的堿性并沒有取得甲基化的成功；通過不同的方法將C3-羰基掩蔽免费人妻98，但是C8-羰基的烯醇化依然無法抑制国产一级迷奸黄片视频大全；雖然通過將呋喃環(huán)轉化為α，β-不飽和-γ-丁內酯可以抑制烯醇化狼友无码，但內酯環(huán)上的雙鍵遷移又成了新的競爭反應亚洲精品综合福利。

Finally confirmed that,The thighbone and the osteoporosis morbidity is possibly connected protein 6, respectively are: The lactoferrin light chain, membrane association protein A3, the enolase, ATP gather the enzyme, the acetyl coenzyme A reductases, the myo calcium protein; The lumbar vertebra and the osteoporosis morbidity is possibly connected protein 5, respectively are: The actin, the keratin, the enolase, ATP gather the enzyme, the myosin; The thighbone and the strong bone valuable curative effect is possibly connected protein 9, respectively are: The enolase, ATP gather the enzyme, the myo-calcium protein, the creatine activating enzyme isozyme, the phosphoglyceric acid change flavor the enzyme, the myosin, the lactoferrin light chain, the pyruvic acid activating enzyme isozyme, the crown protein; The lumbar vertebra and the strong bone valuable curative effect are possibly connected protein 8, respectively are: The carbonic anhydrase, the actin, the αB-crystal protein, 3-phospho-glycerol aldehyde oxidase, the serum albumin, ATP gather the enzyme, the myosin, the enolase.

最后確認：股骨與骨質疏松發(fā)病可能相關的蛋白6個，分別為：乳鐵蛋白輕鏈亚洲欧洲久久精品久久、膜聯蛋白A3亚洲中文字幕5、烯醇化酶、ATP合酶日韩亚洲免费、乙酰輔酶A還原酶一级大黄色电影、肌鈣蛋白；腰椎與骨質疏松發(fā)病可能相關的蛋白5個欧美日韩精品视频一区二区在线播放，分別為：肌動蛋白欧美一级A片视频、角蛋白、烯醇化酶高清无码小视频、ATP合酶91精品啪在线观看国产蜜臀、肌球蛋白；股骨與強骨寶療效可能相關的蛋白9個A片黄片视频在线免费观看，分別為：烯醇化酶18禁又污又黄又爽的网站日本、ATP合酶、肌鈣蛋白亚洲av无码无线在线观看、肌酸激酶同工酶少妇按摩一区二区三区、磷酸甘油酸變味酶、肌球蛋白成年无码Av动漫网站黄、乳鐵蛋白輕鏈欧美的一级片、丙酮酸激酶同工酶、冠蛋白国产AV无码中文；腰椎與強骨寶療效可能相關的蛋白8個国产精品一级二级，分別為：碳酸酐酶、肌動蛋白亚洲无码精选、αB-晶體蛋白国产精选自拍AV、3-磷酸甘油醛脫氫酶、血清白蛋白操逼视频日本、ATP合酶可以免费看欧美搞黄视频的视频网站、肌球蛋白、烯醇化酶夜夜狠狠青草伊人中文字幕。

enol ether：烯醇醚

enol ester 烯醇酯 | enol ether 烯醇醚 | enolase 烯醇化酶

NNE non-neuronal enolase：非神經元性烯醇化酶

NK natural killer 自然殺傷細胞 | NNE non-neuronal enolase 非神經元性烯醇化酶 | NP neuropeptide 神經肽

enolate：烯醇化物

enolase 烯醇酶 | enolate 烯醇化物 | enolizability 烯醇化程度

enolate：烯醇鹽,烯醇酯

烯醇<> enolase | 烯醇鹽,烯醇酯 enolate | 烯醇化[作用] enolization

enolate anion：烯醇陰離子

enolase 烯醇酶 | enolate anion 烯醇陰離子 | enolization 烯醇化

enolic acid：烯醇酸

enolization 烯醇化<作用> | enolic acid 烯醇酸 | enolate 烯醇鹽

enolization：烯醇化

enolase 烯醇化酶 | enolization 烯醇化 | enolpyruvate phosphat 烯醇丙酮酸磷酸

enolization：烯醇化作用

enolase 烯醇酶;磷酸丙酮酸水合酶 | enolization 烯醇化(作用) | enologist 葡萄酒釀造者(工人、技師等)

enolization：烯醇化/烯醇化作用

enolizability /烯醇化程度/ | enolization /烯醇化/烯醇化作用/ | enology /葡萄酒釀造學/

enolize：使烯醇化

D-glycero- D-甘油 | enolize使烯醇化 | enolase烯醇化酶