This invention provides compounds of Formula; wherein: R is a moiety selected from the group: and n is an integer of 1 or 2; R is selected from hydrogen, amino,-NRR, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted, halogen, and a 5 to 10 membered heteroaryl ring optionally substituted, having 1 to 4 heteroatoms independently selected from N, O and S; R is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R is H, alkyl of 1 to 12 carbon atoms optionally substituted, cycloalkyl of 3 to 8 carbon atoms, bicycloalkyl of 5 to 10 carbon atoms or aralkyl optionally substituted; R is OH or -OH; R and R are each independently H or alkyl of 1 to 12 carbon atoms or when optionally taken together with the nitrogen atom to which each is attached form a 3 to 8 membered saturated heterocyclyl ring; R is alkyl of 1 to 12 carbon atoms optionally substituted; or a tautomer or pharmaceutically acceptable salts thereof.

本發(fā)明提供式的化合物欧美片在线观看；其中：R 1 為選自基團(tuán)和的部分一级A片免费在线；n為整數(shù)1或2亚洲欧美另类中文字幕；R 2 選自氫、氨基巨胸流奶水视频网站、-NR 6 R 7 国产日本一区二区在线视频、具有1到12個(gè)碳原子的視情況經(jīng)取代的烷基、具有6個(gè)、10個(gè)或14個(gè)碳原子的視情況經(jīng)取代的芳基最新麻豆精品视频、具有2到12個(gè)碳原子的視情況經(jīng)取代的烯基精品国产色哟哟在线观看、具有2到12個(gè)碳原子的視情況經(jīng)取代的炔基、鹵素和具有1到4個(gè)獨(dú)立地選自N免费人成视頻在线播放、O和S的雜原子的視情況經(jīng)取代的5元到10元雜芳基環(huán)高清在线中文字幕一区；R 3 選自氫、具有1到12個(gè)碳原子的視情況經(jīng)取代的烷基一个人看的免费无码视频网站、具有6個(gè)性生活黄色网站、10個(gè)或14個(gè)碳原子的視情況經(jīng)取代的芳基、具有2到12個(gè)碳原子的視情況經(jīng)取代的烯基色屋永久无域名无码视频网站、乙烯基狼友视频无码、具有2到12個(gè)碳原子的視情況經(jīng)取代的炔基和鹵素国产黄网站在线观看免费版；R 4 為H国产97av、具有1到12個(gè)碳原子的視情況經(jīng)取代的烷基、具有3到8個(gè)碳原子的環(huán)烷基一级A爱视频免费看、具有5到10個(gè)碳原子的雙環(huán)烷基或視情況經(jīng)取代的芳烷基久久久综合；R 5 為OH或-OH 8 ；R 6 和R 7 各自獨(dú)立地為H或具有1到12個(gè)碳原子的烷基18禁漫画网站，或當(dāng)視情況與其所連接的氮原子連接在一起時(shí)形成3元到8元飽和雜環(huán)基環(huán)十八岁一上看的黄片；R 8 為具有1到12個(gè)碳原子的視情況經(jīng)取代的烷基；或其互變異構(gòu)體或醫(yī)藥學(xué)上可接受的鹽欧美巨屌性爱。

In this thesis, 1, 5-diaryl-3-pyrazilidinones, 1, 5-diaryl-3-hydroxypyrazoles and 3-(2, 3, 4, 6-tetraacetyl-β-D-glucopyranos-1-yl)-1, 5-diaryl-1H-pyrazoles are designed and synthesized.1, 5-diaryl-3-pyrzolidinones were obtained by condensation of 3-arylpropenates and phenylhydrazine or fluorophenylhydrazine under the catalysis of sodium methylate and the yields were about 55-80%.

在本文中迷奸视频网站，設(shè)計(jì)合成了1，5-二芳基-3-吡唑烷酮化合物美女免费黄色网站a、1九色永久地址，5-二芳基-3-吡唑烷酮化合物和3-(2，3A级毛片不卡免费视频观看，4国产真实偷人视频在线看，6-四乙酰基-β-D-吡喃葡萄糖-1-基)-1无码AV天堂一区二区，5-二芳基吡唑化合物一级片的视频。以3-芳基-2-丙烯酸酯為原料，與芳基肼在醇鈉的催化作用下性交配视频网站35，反應(yīng)可以生成1久久2视频，5-二芳基-3-吡唑烷酮，產(chǎn)率在55%以上操操射射。

In chapter 4 an abnormal reaction that the nitro group of 1-aryl-2-nitroethenescan be easily replaced by the organic moity of FG-RZnI using Ni〓 and tertiaryamine as catalyst was first given. The experimental results show that in the presenceof catalytic amount of Ni〓 and tertiary amines, the reaction of FG-RZnI andl-aryl-2-nitroethenes give the substitution products l-aryl-l-alkene, instead ofMichael addition products.

通過(guò)實(shí)驗(yàn)發(fā)現(xiàn)搜索黄片搜索黄片黄色毛片，在催化量的Ni〓及叔胺催化下， l-硝基-2-芳基乙烯與烷基碘化鋅并不進(jìn)行Michael加成反應(yīng)，而是發(fā)生1-硝基-2-芳基乙烯中硝基被取代的反應(yīng)日韩在线欧美成人网，生成了高產(chǎn)率的1-芳基-l-烯烴aV黄色一级A片，由于此反應(yīng)的原料易得、反應(yīng)條件溫和插插国产、產(chǎn)物的產(chǎn)率高99久久免费精品国产精品九九，因而是合成l-芳基-1-烯烴的有效方法。

The compounds are represented by the structural Formula 1, Chemical formula should be inderted here as it appears on the abstract in paper form. a prodrug thereof, or any pharmaceutically acceptable salt, solvate, isomer or racemic mixture of the compound or said prodrug wherein R1 is heteroaryl, N-arylaminocarbonyl, N-heteroarylaminocarbonyl, benzimidazolyl or benzothiazolyl; R15 is present or not and if present is H, aryl, alkyl, arylalky or heteroarylalkyl; A is aryl, heteroaryl, cycloalkyl, cycloalkylidene, heterocycloalkylidene or heterocycloalkyl wherein said aryl, heteroaryl, cycloalkyl, cycloalkylidene, heterocycloalkylidene and heterocycloalkyl moieties may be substituted or unsubstituted; and B, L, X and R18 are defined herein.

所述化合物用結(jié)構(gòu)式1表示超碰在线妓女，包括其前藥或所述化合物或所述前藥的任何藥學(xué)上可接受的鹽又粗又大又长又硬起来了、溶劑合物、異構(gòu)體或外消旋混合物亚洲肏穴，其中R 1 為雜芳基欧美三级高清在线、N-芳基氨基羰基、N-雜芳基氨基羰基久久伊人青草、苯并咪唑基或苯并噻唑基AAAAAAAAA性关系视频；R 15 存在或不存在，如果存在97特大黄片，則為H欧美性爱直播、芳基、烷基狠狠se狠狠ri91视频、芳基烷基或雜芳基烷基igao日韩无码；A為芳基、雜芳基欧美日韩亚洲、環(huán)烷基日韩一区在线观看、環(huán)烷叉基、雜環(huán)烷叉基或雜環(huán)烷基亚洲欧洲国产码专区在线男男，其中所述芳基日韩手机福利写真网站、雜芳基、環(huán)烷基人人草人人爽、環(huán)烷叉基自拍日韩在线观看视频网站免费、雜環(huán)烷叉基和雜環(huán)烷基部分可被取代或未被取代；B国产福利在线观看免费第一福利、L无码特级毛片A片、X和R 18 如說(shuō)明書(shū)所定義。

Also useful are oil-soluble copper dithiocarbamates of the general formula Rc Rd z Cu, where z is 1 or 2, and Rc and Rd are the same or different hydrocarbyl radicals containing from 1 to 18, and preferably 2 to 12, carbon atoms, and including radicals such, for example, as alkyl, alkenyl, aryl, aralkyl, alkaryl and cycloaliphatic radicals.

化學(xué)通式為Rc Rd z Cu的油溶性二硫代氨基甲酸銅也適用美美女一级A片视频，式中日韩无码三级片免费观看，z為1或2，Rc和Rd是含1～18（以2～12為宜）個(gè)碳原子的相同或不同的烴基欧美日韩性爱AAA视频，這類(lèi)烴基的實(shí)例包括烷基黄色网站在线看免费。、烯基国产东北老妓女视频在线播放、芳基、芳烷基自拍视频最新日韩欧美、烷芳基和脂環(huán)基91亚洲精品自在在线观看不卡的。

In this thesis, two series compounds of thiadiazole (2a~2f) and benzothiazole (5a~5f) were synthesized by using the reagent of iodobenzene diacetate. We also bound the iodobenzene diacetate reagent to the resin and applied it to synthesize thiadiazole and benzothiazole compounds.

本文利用二醋酸碘苯試劑分別與1-芳甲酰基-5-芳基-2-硫代縮二脲及1-芳甲跖分奚访酪磺?7；?3-芳基硫脲反應(yīng)合成了噻二唑(2a~2f)和苯并噻唑(5a~5i)兩個(gè)系列的雜環(huán)衍生物国内JIZZ，并通過(guò)把二醋酸碘苯負(fù)載在高分子上合成了一類(lèi)新型的固相氧化劑，同時(shí)考查了該固相氧化劑在噻二唑在线观看污色视频，苯并噻唑類(lèi)化合物合成中的應(yīng)用以及該固相氧化劑的循環(huán)使用亚洲精品福利视频。

The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted C1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het1, Het2; R1 may also be a radical of formula (R11aR11b)NC(R10aR10b)CR9-; t is 0, 1 or 2; R2 is H or C1-6alkyl; L is -C-,-O-C-,-NR8-C-,-O-C1-6alkanediyl-C-,-NR8-C1-6alkanediyl-C-,-S2-,-O-S2-,-NR8-S2 ; R3 is C1-6alkyl, aryl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, or arylC1-4alkyl; R4 is H, C1-4alkylOC, carboxyl, aminoC, mono- or di(C1-4alkyl)aminoC, C3-7cycloalkyl, C2-6alkenyl, C2-6alkynyl or optionally substituted C1-6alkyl; R5 and R6 are H or C1-6alkyl.

本發(fā)明涉及右式化合物其N(xiāo)-氧化物、鹽西安一级毛片、立體異構(gòu)形式日韩视频一区二区、外消旋混合物、前藥久久久精品区、酯及代謝物中文无码性爱，其中R 1 及R 8 各是氫、C 1-6 烷基aaaaa色色黄色视频、C 2-6 烯基男人到天堂亚洲一区二区在线观看、C 3-7 環(huán)烷基欧美大胆A片、芳基免费直接在线看黄、Het 1 、Het 2 国产精品蝌蚪专区无码；R 1 也可以是式(R 11a R 11b )NC(R 10A R 10b )CR 9 -之基国产一区高跟丝袜在线观看；t是0、1或2亚洲欧色图一级；R 2 是氫或C 1-6 烷基国产作爱视频免费播放；L是-C-、-O-C-99久久com、-NR 8 -C-亚洲无码色色色、-O-C 1-6 烷二基-C-、-NR 8 -C 1-6 烷二基-C-又爽又黄又舒服的网站视频、-S 2 -十八禁免费AV网站在线观看，-O-S 2 -、-NR 8 -S 2 -久久免费看一级毛片一级A片；R 3 是C 1-6 烷基欧美色色色、芳基、C 3-7 環(huán)烷基成人十八黄色网站视频国产、C 3-7 環(huán)烷基C 1-4 烷基或芳基C 1-4 烷基在线一区二区观看；R 4 是氫av不卡在线、C 1-4 烷基OC、羧基中文字幕专区、氨基C激情综合丁香五月、一-或二(C 1-4 烷基)氨基C、C 3-7 環(huán)烷基青娱精品在线p、C 2-6 烯基国产福利小视频在线观看资源网站、C 2-6 炔基或任選被取代的C 1-6 烷基；R 5 及R 6 是氫或C 1-6 烷基人人操97caop。

Base played a crucial role in this reaction: in the Pd2/L1 catalyzed α-arylation of ethyl malonate, K3PO4 is the base of choice; in the α-arylation of ethyl acetoacetate, K2CO3 is the most effective base.

在這類(lèi)催化反應(yīng)中日韩精品一区二区三免费视频，堿的選擇具有重要的影響：以K3PO4為堿， Pd2/L1催化體系在丙二酸二乙酯的α-芳基化中人人干人人97，富電子溴代芳烴顯示較好的活性欧美又肥又大又色性爱视频； Pd2/L1催化的乙酰乙酸乙酯α-芳基化時(shí)，以 K2CO3為堿欧美艳情性爱视频网址，催化體系顯示較好的活性国产精品久久久亚洲一区，這個(gè)催化體系可控制反應(yīng)得到α-芳基乙酰乙酸乙酯，而不是脫乙跞巳烁扇巳瞬傥缫估砺郏基的產(chǎn)物91在线精品欧美观看。

Base played a crucial role in this reaction: in the Pd2/L1 catalyzed α-arylation of ethy malonate, K3PO4 is the base of choice; in the α-arylation of ethyl acetoacetate, K2CO3 is the most effectiv base.

在這類(lèi)催化反應(yīng)中，堿的選擇具有重要的影響：以K3PO4為堿国产原创无码视频在线观看，Pd2/L1催化體系在丙二酸二乙酯的α-芳基化中bbbxbbbxx，富電子溴代芳烴顯示較好的活性；Pd2/L1催化的乙酰乙酸乙酯α-芳基化時(shí)在綫看中文字幕，以K2CO3為堿在线免费AV播放，催化體系顯示較好的活性，這個(gè)催化體系可控制反應(yīng)得到α-芳基乙酰乙酸乙酯一级黄色在线观看，而不是脫乙跖访酪患蹲鲆患禔片视频大鸡巴破处；漠a(chǎn)物。

Examples of metal chelating groups include hydroxides especially aryl or heteroaryl hydroxides such as phenolic hydroxides; amines which may be aliphatic aryl or heteroaryl; mercaptans which may be aliphatic aryl or heteroaryl; carboxylic acids which may be aliphatic aryl or heteroaryl; oximes and ketoximines; acetarylamides; hydroxy silanes and silicones; N-containing heterocycles such as imidazoles benzimidazoles triazoles benzotriazoles thiazoles isothiazoles acid anhydrides and more preferably acid groups (especially carboxylic acid groups phosphoric acid groups polyphosphoric acid groups phosphonic acid groups sulphuric acid groups and sulphonic acid groups).

金屬螯合組的例子包括氫氧化物又色又大又粗又硬又爽动态视频，特別是芳基或如酚醛氫氧化物雜氫氧化物插进去插快点视频；胺可能是脂肪族，芳基或雜美女双腿张开被操出白浆；硫醇可能是脂肪族日韩欧美一区二区在线观看，芳基或雜，這可能是脂肪族一级黄色人AV在线，芳基或羧酸雜国产一级一级A一级A级；肟和ketoximines； acetarylamides殴美伊人一本在线观看av；羥基硅烷和有機(jī)硅黄色网址在线免费，含N久久精品A片777777，如咪唑，苯并咪唑類(lèi)日韩欧清无码激情性视频，三唑類(lèi)一级特黄特色的免费网站，苯并三氮唑，噻唑類(lèi)www.jjzz日本视频，isothiazoles黄片视频2019，酸酐雜環(huán)，多最好酸組（特別是羧酸團(tuán)體尤物网站视频免费看，磷酸人人操人人操操，團(tuán)體，多聚酸組影音先锋中文字幕资源，膦酸組免费网站在线观看人成视频，硫酸團(tuán)體和磺酸組）。

diaryl arsenious acid：二芳基亞胂酸

www.mapeng.net 馬棚網(wǎng) | diaryl arsenious acid 二芳基亞胂酸 | diaryl arsine oxyhalide 二芳基胂化氧鹵

aryl：芳基

芳烴分子去掉一個(gè)氫原子所剩下的基團(tuán)稱(chēng)為芳基(Aryl)用Ar表示. 重要的芳基有:

aryl：芳基,芳基的

aryl thiourea | 芳基硫脲 | aryl | 芳基 芳基的 | arylate | 芳基化物

aryl sulfatase：芳基硫酸酯酶

aryl hydrocarbon receptor芳(香)烴受體 | aryl sulfatase芳基硫酸酯酶 | arylation芳基化

aryl sulfatase：芳基硫酸酯

aryl hydrocarbon receptor 芳(香)烴受體 | aryl sulfatase 芳基硫酸酯 | arylation 芳基化

aromatophor：芳基

aromatizing cracking 芳化裂煉 | aromatophor 芳基 | arone 芳酮

aromatophor; aryl group：芳基

"aromatizing cracking","芳化裂煉" | "aromatophor; aryl group","芳基" | "arone","芳酮"

arylamine：芳基胺

aryl halide 芳基鹵 | arylamine 芳基胺 | arylation 芳基化

arylate：芳基化物

aryl | 芳基 芳基的 | arylate | 芳基化物 | arylated alkyl | 芳脂基

diaryl arsine oxyhalide：二芳基胂化氧鹵

diaryl arsenious acid 二芳基亞胂酸 | diaryl arsine oxyhalide 二芳基胂化氧鹵 | diaryl hydroxy arsine 二芳基亞胂酸