Material and MethodsRA Rabbit Model group: 15 early RA rabbits of the same weight and variety Control group:10 normal rabbits of the same weight and varietyMethods of making RA rabbit model:elect 15 normal rabbits of the same weight and variety, dissolve Ovalbumin in 0.9% sodium chloride solution, to make the solution of 20mg/ml concengtration, blend the same quantity of complete Freund′s Adjuvant equably ,inject the mixed solution into endermic tissue of the rabbit′s scapular section, making the rabbits allergic, inject 1 ml of the mixed solution to one rabbit every time, inject 1 ml of the mixed solution in 5 different places of the rabbit′s scapular section, inject the rabbit one time every week,inject 3 weeks continuously,it turned out to be that the rabbits will be allergic, inject Ovalbumin blent with the 0.9% sodium chloride solution into the knee joint cavity of the rabbits in the fourth week, 5 mg Ovalbumin every knee joint cavity,two knees of every rabbit of the 15 rabbits are both injected,the arthrosis diameter and the exterior temperature of the knees will be added obviously in 24 hours,and they will drop gradually,at the time of the 14th or 21th day, the arthrosis diameter and the exterior temperature of the knees will get to the balance time,the incidence rate of RA is 100%.after the RA model succeeds,it is the early time of RA from the first week to the fourth week,after the fourth week,it is the late time of RA, the cartilage of the femoral condyle and the subchondral bone cortices will be changed unrecoverily.

資料與方法RA模型組：早期RA家兔模型15只你懂得在线网站，品種及體重接近亚色91。對照組：正常家兔10只，品種及體重接近国产拍线一区观看。RA家兔模型制作方法：選取15只成年家兔亚洲美女黄色，體重、品種接近人人操人人草人人爱，將卵蛋白溶解于生理鹽水黑人乱伦，配成濃度為20mg/ml的溶液，與等量完全弗氏佐劑混勻人人干人人插视频，注入家兔肩胛區(qū)皮下致敏99re在线视频，每只家兔每次注射1ml，于肩胛區(qū)5個(gè)不同區(qū)域注射影音先锋最新AV资源网站，每周一次α片一区，連續(xù)注射3周而致敏，第4周向膝關(guān)節(jié)腔注射卵蛋白生理鹽水溶液一级A片高潮喷免费观看，每只關(guān)節(jié)腔注射5mg卵蛋白永久免费AV网站可以直接看的，15只家兔膝關(guān)節(jié)全部注射，24h內(nèi)此關(guān)節(jié)直徑和表面溫度大幅度上升人人操人人摸人人干96，以后緩慢下降思思欧美另类自拍，至14～21d達(dá)到平臺期，發(fā)病率達(dá)100%黄色网址观看免费。造模成功后第1～4周為早期改變99riAV9国产，第4周以后出現(xiàn)不可逆的關(guān)節(jié)軟骨及骨破壞。采用高頻超聲對RA模型組與對照組的膝關(guān)節(jié)髕上囊液體厚度大乱婬交欧美视频一区、滑膜及股骨髁軟骨厚度及軟骨下骨皮質(zhì)的回聲情況進(jìn)行對比觀察顶级大樵片。結(jié)果RA組模型組膝關(guān)節(jié)髕上囊積液及滑膜的厚度明顯厚于對照組，其股骨髁軟骨的厚度與對照組相比無明顯差異操逼免费视频网址，其軟骨下骨皮質(zhì)與對照組相比無明顯改變亚洲欧洲av官网。

RA was observed to have a tendency towards family aggregation, as the morbidity of RA was up to 30% in monovular twins, 5% in non-identical twins, which demonstrated the occurrence of RA associated to genetic factors.

有研究發(fā)現(xiàn)RA有家族聚集傾向，單卵雙生子發(fā)病率為30％色区综合网，雙卵雙生子為5％4444免费，說明RA發(fā)病與遺傳因素有關(guān)。

PLT and PCT of RA patients in active phase were increased, and have correlation with reactive indexes. It suggests that PLT, PCT can reflect reactiveness of RA as objective indexes. XFC can not only treat inflammation and delay the aggravation of RA patient by improving platelet ultrastructure.

活動期RA患者PLT亚洲大尺度视频无码专区、PCT顯著升高A级毛片无码免费真人久久久，且與各活動性指標(biāo)具有相關(guān)性视频在线看一区二区，提示PLT、PCT可作為反映RA活動性的客觀指標(biāo)亚洲日韩另类一区欧美；新風(fēng)膠囊能通過改善血小板超微結(jié)構(gòu)從而減少CD62P釋放來改善RA患者的關(guān)節(jié)炎癥病變想要看的一级黄片福利在线免费看，延緩病情進(jìn)展。

MPV assumed to he negative correlation with arthrocele, violet and dark oral lip, scaly skin. Conclusion:(1) PLT, PCT is relevant with RA patients' condition, this can he an index of operative of disease.(2) PLT, PCT, MPV is relevant with the symptom of RA's stagnation of blood, this can he an index of laboratory.

(1)PLT亚洲毛片一级无码网站、PCT與RA病情變化有關(guān)啪啪啪资源，可作為判斷RA疾病活動的臨床指標(biāo)；(2)PLT三级片黄片av免费在线播放、PCT99精品热、MPV與RA血瘀證癥狀相關(guān)，可作為指導(dǎo)臨床辨證用藥及判斷中醫(yī)藥療效的實(shí)驗(yàn)室指標(biāo)欧美三级黄色片女人性觉片。

Objective: RA is an autoimmune chronic systemic disease, characterized by inflammation, self-immune and the hyperplastic synovial pannus.

目的：類風(fēng)濕關(guān)節(jié)炎(rheumatoid arthritis欧美色污在线视频，RA)是一種慢性系統(tǒng)性疾病，其主要病理改變是滑膜炎和血管翳形成及其相關(guān)的血清組織中多種細(xì)胞因子亚洲国产精品激情一区二区、抗原抗體和粘附分子等的變化人人操人人爱97，而細(xì)胞因子是RA炎癥和損傷的重要介質(zhì)，對RA患者外周血及滑液中細(xì)胞因子改變已有大量研究日韩欧美视频，已證明多種細(xì)胞因子參與RA的病變過程黄网站在线观看免费_。

There were significant differences between RA and non-RA groups in morning stiffness, symmetric arthritis, rheumatoid factor positivity, erythrocyte sedimentation rate, C-reactive protein and synovial hyperplasia, enhanced pannus, bone marrow edema as well as bone erosion.

晨僵、對稱性關(guān)節(jié)腫脹无码A级毛片免费视频、類風(fēng)濕因子(rheumatoid factor久久精品久久， RF)陽性、血沉(erythrocyte sedimentation rate国产91精选在线看， ESR)增快激情乱小说欧美视频、C反應(yīng)蛋白(C-reactive protein， CRP)值升高諸指標(biāo)在RA組與非RA組之間具有顯著差異性做a免费视频播放网站。MRI各主要征象中滑膜增厚色色色.com、血管翁強(qiáng)化、骨髓水腫91pao精品永远免费网站、骨侵蝕諸指標(biāo)RA組與非RA組之間具有顯著差異性黄视频中文字幕。

TyPe II collagen induced arthritisln the rat ank1e joint andoVathumin as antigen induced arthritis WA in the rabbit knee joint wereestab1ish2 Qualitative evaluation of me in skin, muscle, synovium, cedilagearound joint and blood was performed by OMA3 The CIA rats were treated on day 7 after hind paw swelling and erythemaAnimals were injected intravenously with ase at a dose of 10mg/kg,tWenty minuots 1ater, one ankle of the rats random1y assigned was exPosedlaser irradiation at l00J/cm fOr l000 seconds, and another ankle wasM grouP wihout laser The other two groups is unmanipulatedcontrol group and untreated CIA group Bimaleolar ankle widthmeasuremellts were taken in all animals every tWo days using amicrometer The histopathology of the ank1e Joint was assessed at day 21after disease onset4 The pro1iferating cell nuclear antigen WCNA of CIA treated by PDT andthe HMME group without laser was doterdrined by immunohistochemiStry5 The AfA rabbits were treated on day 7 after knee swelling and erythemaThe theraPy invo1ved lntravenous injection of l0mg/kg HMME, fOl1owedby 20 minues period in dim light, and transdermal light treatment with\l00 J/cm2 fOr l000 seconds The inner sides of the treated Anees wereirradiated at first, and then the outer side did 24 hours later, the synovialtissue of the Anees joint were removed and in situ cel1 aPoptosis wasdetCCted With tednal deoxync1eotidyl transferase-mediated dUTP nickend labelingR6suIt8:l The pathologic changes of CIA and AIA include subsynovial inflammation,opovial hyPerplasia, pannus formation, cartilage and bone destructionresemble RA.2 The studies demonstrated that there are different uptake of HMME withinskin, muscle, synovium, cartilage and b1ood, and the synovium cou1draPidly uPtake more ase than skin and cartilage at the firSt 30 minuesaller intravenous injection of HMME3 The bimaleolar anke width had no different among PDT treated group,H group withollt 1aser and untreated CIA group But hlstologicalevaluation showed statiStical1y significallt reductions in synovialhyperplasia, pannus formation and cart1lage reosion, bone destruction andtotal score in PDT treated group4 Image analysis showed that the ratlo bforeen the areas of the coufltedobect to that of the entire area in PDTtreated grOup is lower than that in conirol group, but the integrated oPticaldensity had no different between the two groups5 Imape analysis showed that the ratio between the area of the countedobject to that of the e

治療組在大鼠出現(xiàn)踝關(guān)節(jié)紅腫后1周，炎癥達(dá)到高峰時(shí)進(jìn)行PDT治療福利网站导航。隨機(jī)治療大鼠一側(cè)的踝關(guān)節(jié)欧美性爱色爱，另免费一级毛片无码视频。2小一黄色网站在线观看。一一側(cè)作單純HMME 對照。治療方法是大鼠麻醉后尾靜脈注入 HMME10ngkg91麻豆精品婷婷五月，20分鐘后踝關(guān)節(jié)照光a黄视频，激光波長627.sum√天堂中文www官网在线，功率密度 100mwcm'，照射時(shí)間1000秒日本网站视频高清，能量密度100）／16xxxxx。治療后避光喂養(yǎng)72 小時(shí)。隔日一次測量大鼠的踝關(guān)節(jié)左右橫徑日本aa在线播放，治療后兩周取關(guān)節(jié)進(jìn)行病理d 觀察欧美一级a一级a一级a视频。 4。大鼠CIA模型用上述方法進(jìn)行PDT治療后成人人操，治療組和單純HMME 組用兔疫組化SP法檢測石蠟切片的核增殖抗原男女无遮掩激情免费视频。 5。兔AIA模型在關(guān)節(jié)炎出現(xiàn)第七天進(jìn)行PDT治療看一级毛片一区二区三区免费，隨機(jī)治療一側(cè)膝關(guān)節(jié)欧美性爱特级黄，另一側(cè)作自身對照。兔耳靜脈注入I'arrainrelomg／Kg欧洲精品欧美精品，20分鐘后777av视频，膝關(guān)節(jié)用金蒸氣激光照射，激光能量密度100）兒曠欧美视频小说在线观看。24 ／J'時(shí)后取膝關(guān)節(jié)滑膜作病理檢查在线免费观看视频黄片，并用脫氧核昔酸末端轉(zhuǎn)移酶介導(dǎo)的缺口末端標(biāo)記法原位檢測凋亡細(xì)胞。結(jié)果： 1免费观看黄色网站视频。模型觀察：CIA大鼠炎癥高峰期滑膜下炎細(xì)胞浸潤明顯92看片婬黄大片一一，滑膜細(xì)胞明顯增殖，炎癥達(dá)到高峰后二周黄色av丝袜，血管綴形成黄片国产一级欧美操逼的免费观看，并侵蝕和破壞軟骨和骨， CIA模型病理改變與人類RA相似久久奶水A毛片免费看。兔AIA模型膝關(guān)節(jié)滑膜病理可見滑膜細(xì)胞增生欧美69囗交视频，滑膜下炎細(xì)胞浸潤，也與人類RA滑膜改變相似亚洲第二区在线视频。 2手机黄片亚洲。關(guān)節(jié)周圍組織中光敏劑含量的測定結(jié)果表明，各組織對HMME 的吸收速度和吸收量不同人人摸人人操人人上，熒光值一時(shí)間曲線不同日韩一级视频免费观看，滑膜組織比皮膚和軟骨對 HMME的吸收多，在 2 0分鐘時(shí)即有明顯差異黄片首页。 3.PDT對CIA模型的治療結(jié)果表明：PDT治療后關(guān)節(jié)炎組国产偷亚洲偷欧美偷精品导航、單純 HMME組和治療組踝關(guān)節(jié)左右橫徑統(tǒng)計(jì)學(xué)檢驗(yàn)差異沒有顯著性，但病理評分PDT治療組滑膜增生、血管資形成及軟骨破壞人人澡人人舔、骨破壞和總分比關(guān)節(jié)炎對照組和HMME對照組好一区二区三区四区欧美日韩，統(tǒng)計(jì)學(xué)檢驗(yàn)差異有顯著性。哪里能看毛片。3＿軍醫(yī)進(jìn)修學(xué)院碩士學(xué)位論文中文摘要 4.PDT治療組PCNA陽性細(xì)胞較對照組少国产在线视频国产在线，圖像分析結(jié)果表明面密度（陽性染色的面積總和與統(tǒng)計(jì)視野面積的比值）治療組小于對照組，統(tǒng)計(jì)學(xué)檢驗(yàn)差異有顯著性尤物网视频在线。美女网页黄a。 5.PDT治療組凋亡陽性細(xì)胞較對照組明顯增多，圖像分析結(jié)果單位視野內(nèi)陽性細(xì)胞數(shù)和面密度PDT治療組高于對照組欧美一级A片视频在线，統(tǒng)計(jì)學(xué)檢驗(yàn)差異有顯著性欧美色色精品。凋亡細(xì)胞核直徑PDT治療組較小，與對照組相比久久免费精品国产72精品九九，統(tǒng)計(jì)學(xué)檢驗(yàn)差異有顯著性最近中文字幕免费视频在线。結(jié)論：二。CIAwww。射、AIA的病理改變類似人類RA91在线亚洲视屏，可作為研究RA病因、發(fā)病機(jī)制国产精品无码三级在线播放一区、檢查及治療方法的模型欧洲一级毛片。 2。各組織對HMME的吸收速度和吸收量不同免费一极a片，滑膜組織比皮曰本另类女同专区久久精品。

The six kinds of nanoparticles water dispersion were as follows:rotenone/carboxymethyl chitosan-grafted-ricinoleic acid(Rot/CMC-g-RA), azadirachtin/carboxymethyl chitosan-grafted-ricinoleic acid(Aza/CMC-g-RA),capsaicin/ carboxymethyl chitosan-grafted-ricinoleic acid(Cap/CMC-g-RA),rotenone/ricinoleic acid sodium,capsaicin/ricinoleic acid sodium,azadirachtin/ricinoleic acid sodium.

分別為：魚藤酮/羧甲基殼聚糖接技蓖麻油酸共聚物(Rot/CMC-g-RA)、辣椒堿/羧甲基殼聚糖接技蓖麻油酸共聚物(Cap/CMC-g-RA)和印楝素/羧甲基殼聚糖接技蓖麻油酸共聚物(Aza/CMC-g-RA)納米粒子水分散制劑美国一级做a一级视频，以及魚藤酮/蓖麻油酸鈉日韩毛片毛片久久精品、辣椒堿/蓖麻油酸鈉和印楝素/蓖麻油酸鈉納米粒子水分散微乳液。

Expect for a few pittings,the N+1-implanted surface had a best fineness (average roughness Ra≈4.2nm), close to the unimplanted original surface.The N+2-implanted surface had a black dendritic area,and had a poorer fineness (Ra≈16nm).While in the N+10-implanted surface appeared a ripple structure,with the poorest fineness (Ra≈40nm).

但其表面形貌各異：N+1注入的表面除存在少量點(diǎn)蝕坑外久久久久久久久久艹，光潔度最高(平均粗糙度Ra≈4.2nm)永久免费A片在线观看全网站妓女，接近未注入前的原始表面(Ra≈3.5nm)；N+2注入的出現(xiàn)黑色枝狀區(qū)域国外最大AV，光潔度次之(Ra≈16nm)黄片a级a级a级，而N+10注入的則出現(xiàn)&波紋&狀結(jié)構(gòu)，光潔度最差(Ra≈40nm)福利影院地址。

It comprises: CN pages call and the page message carries the sonic service information, as the sonic service of CS region; UE responds page, and sends the sonic service information to RNC in the initial access request message; RNC receives request and makes sure it is sonic service of CS region, to decide one sonic speed parameter Rm, and based on the resource demand, to build one wireless chain and ground load between Iub interface signal and service, and the signal and service load of wireless interface; UE and CN processes QoS consultation, and CN sends the consulted Qos parameter to RNC, which comprises a sonic speed parameter Ra of this service; RNC compares parameter Ra and Rm, if Ra is higher then Rm, builds the ground load of Iu interface and sends distribution answer message to CN to continuously page answer process.

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