Additionally XBP1 mRNA which functioned as centrally regulating molecule during ER stress was spliced partially,while it was completely spliced in positive control cells and unspliced in H7721.These results gave the proof that blocking expression of GnT-V caused H7721"s ER stress and response was more weak than that caused by DTT. It may be the chronic process.Additionally,previous studies reported that the ds-RNA may activate the kinase PKR which phosphorylated eIF2 α and inhibited synthesis of proteins.In this paper the antisense cDNA of GnT-V was integrated with GnT-V-AS/H7721"s gene and functioned through the binding of antisense RNA and mRNA of GnT-V.Additionally,the integration of GnT-V cDNA in genome also may be a non-specific factor.

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Ndustry experts pointed out that because of the huge global footprint of Merck's generic business, domestic biggies like Ranbaxy, Wockhardt and Dr Reddy's could be interested in the company as with one stroke they would have a pan-European presence, as long as their balance sheets are not stretched.

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As with all wars, the starkest toll of Chechnya's are the dead, who as well as the slaughtered Chechens officially include around 10,000 federal troops, and unofficially many more.

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