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For this reason, a novel PPOP was designed and prepared using two side drilling technology and water-insoluble drug gliclazide was employed as model drug. Influencing factors from six aspects were studied which was drug layer formulation, push layer formulation, coating formulation, orifice properties, tableting art and dissolution conditions, respectively, and the difference between the dissolution profiles of novel PPOP and conventional PPOP was also evaluated by similarity factor (f_2). Through determination of the viscosity of drug layer and push layer of the novel PPOP, the mechanism of drug release from novel PPOP was discussed by the help of Poiseuilles law of laminar flow.

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For this reason, a novel PPOP was designed and prepared using two side drilling technology and water-insoluble drug gliclazide was employed as model drug. Influencing factors from six aspects were studied which was drug layer formulation, push layer formulation, coating formulation, orifice properties, tableting art and dissolution conditions, respectively, and the difference between the dissolution profiles of novel PPOP and conventional PPOP was also evaluated by similarity factor (f2). Through determination of the viscosity of drug layer and push layer of the novel PPOP, the mechanism of drug release from novel PPOP was discussed by the help of Poiseuille's law of laminar flow.

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For this reason, a novel PPOP was designed and prepared using two side drilling technology and water-insoluble drug gliclazide was employed as model drug. Influencing factors from six aspects were studied which was drug layer formulation, push layer formulation, coating formulation, orifice properties, tableting art and dissolution conditions, respectively, and the difference between the dissolution profiles of novel PPOP and conventional PPOP was also evaluated by similarity factor (f2). Through determination of the viscosity of drug layer and push layer of the novel PPOP, the mechanism of drug release from novel PPOP was discussed by the help of Poiseuille's law of laminar flow.

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Brief Synopsis: In a hut on the side of a village surrounded by a chain of the Altai Mountains there lives a childless married couple totally rejected by the rest of the community.

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The Covenant of the League of Nations was drafted by a special commission, and the League was established by Part I of the Treaty of Versailles. On 28 June 1919,[25][26] 44 states signed the Covenant, including 31 states which had taken part in the war on the side of the Triple Entente or joined it during the conflict.

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