Last, the design of anti-cancer adlay supplement must be tumor-specific since that the cytotoxicity of the compounds varies depending on the cell line tested and that such variation may in turn influence those combined effects of the pure compounds.

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The general formulas of these compounds are as follows:The strobilurin derivatives were synthesized from substitutedβ-keto esters (2) as starting material which were prepared from substituted ketones (1) and dimethyl carbonate. The ester (2) and methyl hydrazine or substituted amidine were dissolved in methanol and the mixture was heated to reflux to obtain the substituted 5-hydroxy-1H-pyrazole (3) or 4-hydroxy-pyrimidine (4). The title compounds were prepared by reacting the intermediates (3 and 4) with substituted halomethylphenyls which contain four active group under basic conditions.

本論文所合成的strobilurin化合物均是以β-酮酸酯類(lèi)化合物(2)為起始原料合成的羞羞网站在线观看入口免费，該中間體(2)是由酮類(lèi)化合物(1)與碳酸二甲酯在堿性條件下反應(yīng)生成的一级片免费黄色网站，中間體(2)與甲基肼或取代脒類(lèi)化合物在甲醇中回流制得取代的1H-5-羥基吡唑(3)或4-羥基嘧啶(4)77777青操网，中間體(3和4)再與包含四種活性基的芐鹵中間體在堿性條件下制得目標(biāo)化合物。

The genera formulas of these compounds are as follows:The strobilurin derivatives were synthesized from substitutedβ-keto esters (2) as starting material which were prepared from substituted ketones (1) and dimethyl carbonate. The ester (2) and methyl hydrazine or substituted amidine were dissolved in methanol and the mixture was heated to reflux to obtain the substituted 5-hydroxy-1H-pyrazole (3) or 4-hydroxy-pyrimidine (4). The title compounds were prepared by reacting the intermediates (3 and 4) with substituted halomethylphenyls which contain four active group under basic conditions.

本論文所合成的strobilurin化合物均是以β-酮酸酯類(lèi)化合物(2)為起始原料合成的717午夜理论片在线观看影片，該中間體(2)是由酮類(lèi)化合物(1)與碳酸二甲酯在堿性條件下反應(yīng)生成的日韩亚洲三级片电影,AV不卡，中間體(2)與甲基肼或取代脒類(lèi)化合物在甲醇中回流制得取代的1H-5-羥基吡唑(3)或4-羥基嘧啶(4)无码综合网，中間體(3和4)再與包含四種活性基的芐鹵中間體在堿性條件下制得目標(biāo)化合物九九国产色视频。

These studies indicate the rationality of our molecular design based on the crystal structure of KARI complex. To obtain more KARI inhibitors with high activities, the molecular docking and 3D-QSAR methods were applied to our further studying of these amidine compounds. Two methods AutoDock3. 0.3 and DOCK4. 0 were used in molecular docking, and the calculate results accord with that of herbicidal tests in general. The CoMFA model from 3D-QSAR analysis provided useful guidance for designing highly active compounds prior to their synthesis.

這些分子作為潛在的KARI抑制劑為基于KARI的農(nóng)藥分子設(shè)計(jì)提供了有利指導(dǎo)；對(duì)部分小分子進(jìn)行了合成最新av在线免费，在除草活性初篩的近三十個(gè)化合物中，個(gè)別化合物表現(xiàn)出較好的除草活性国产首页在线视频，其中一個(gè)化合物wb1596對(duì)油菜和稗草具有較高的生長(zhǎng)抑制率免费一级毛片在线播放放视频，并通過(guò)E.coli KARI酶活性抑制試驗(yàn)驗(yàn)證了其KARI酶的作用靶標(biāo)欧美国产日韩一区二区三区免费的在线视频，此化合物可以作為KARI一個(gè)有苗頭的抑制劑為后續(xù)工作奠定了基礎(chǔ)；對(duì)發(fā)現(xiàn)的有苗頭的KARI抑制劑進(jìn)行了結(jié)構(gòu)修飾和優(yōu)化国产在线3p，合成了一系列脒類(lèi)化合物并確證了它們的結(jié)構(gòu)欧美激性欧美激情在线小说，改造后的化合物與原抑制劑相比大多除草活性相當(dāng)或更佳三级视频网站视频网站受不了了，從而表明我們基于靶標(biāo)結(jié)構(gòu)的分子設(shè)計(jì)的合理可靠性操X国产；對(duì)所合成一系列脒類(lèi)化合物進(jìn)行了分子對(duì)接和三維定量構(gòu)效關(guān)系研究。

In part one, the reactions of some active fluorine-containing compounds such as 2, 2-dihydropolyfluoroalkanoic acids and ethyl 2-hydropolyfluoroalkenoates were studied and various fluorine-containing heterocyclic compounds were synthesized. Using 2, 2-dihydropolyfluoroalkanoic acids as the starting material, 4-fluoroalkyl quinolin-2-ols, 2- [ -1-hydropolyfluoro-1-alkenyl] -4H-3, 1-benzoxazin-4-ones, 1-aryl -4, 9-dihydro-3-fluoro-alkyl-1H-pyrazo [3, 4-b] quinolin-4-ones, 5-fluoroalkyl-12H-quin olino [2, 1-b] quinazolin-12-ones, 4-fluoroalkyl-1, 3-dihydro-1, 5-benzodiazepin-2-ones and 4-fluoroalkyl-2H-pyrido [1, 2-a] pyrimidin-2-ones were synthesized through its condensation reaction with anilines, anthranilic acid, N'-aryl-o-aminobenzamides, o-nitro aniline, o-amino pyridine and their derivatives and the subsequent transformations. 5-Fluoroalkyl isoxazolidines, 3-fluoro-3-fluoroalkylisoxazolidino [4, 3-c] quinolin-4-ones, 3-fluoroalkylisoxazolino [4, 3-c] quinolin-4-ones and 2-aryl-3per fluoroacylindoles were synthesized by inter-and intramolecular 1, 3-dipolar cycloaddition of fluorine-containing olefins and nitrones.

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A series of antimony mercaptide compounds which formula are Sb 〓 and Sb S (CH〓〓COOR 〓(R represents an alkyl or aryl, aralkyl, n=0～2) have been synthesized. A new synthetic method has been invented to solve the defect of abroad patent method which has complex technological conditions and singleness intermediate compounds. A new catalyst QL-1 and preactivated antimony trioxide and other means have been used to avoid neutralizing, washing, separating and other procedures of intermediate and simplifing process flow at the same time. According to this new technique, a series of antimony mercaptides and their intermediate products have been synthesized with high yield.

合成了結(jié)構(gòu)為SbS(CH〓〓COOR〓及Sb〓（R為烴基或芳烷基亚洲欧美性生活在线看片，n=0～2）的一系列硫醇銻化合物自拍偷拍视频二区，針對(duì)國(guó)外專(zhuān)利報(bào)道的合成工藝存在著工藝條件苛刻免费全网A片，同時(shí)需多步完成，操作復(fù)雜三级片黄色性爱视频在线观看，而且中間體品種單一的缺陷亚洲一区二区国产日韩欧美，發(fā)明了一種一步法合成硫醇銻化合物的新工藝，采用QL-1催化劑黄网址入口，且將三氧化二銻預(yù)先活化亚洲顶级毛片18禁无遮挡，變固—液相反應(yīng)為液—液相反應(yīng)，同時(shí)可免除中間體的中和97资源共享国产美女视频、洗滌在线看片U、分離等工序，工藝流程簡(jiǎn)化又黄又爽又色，產(chǎn)品收率高韩国三级片手机免费观看，且能制得系列硫醇銻產(chǎn)品。

Qingyangshenylycosides is a mixture of several related compounds derived from the root of a Traditional Chinese Medicine, Cynanchum Otophyllum. Pharmacological characterization of the compounds indicated that the drug had a significant antiepileptic and anticonvulsant activity on kindling, rat audiogenic seizures and ferrous sulfate-induced epilepsy.

青陽(yáng)參總甙(Qingyangshenylycosides国产精品夜色视频一区二区，QYS)是蘿摩科鵝絨屬植物青陽(yáng)參根粉提取物日韩国九九精品，已有動(dòng)物實(shí)驗(yàn)表明QYS對(duì)大鼠聽(tīng)源性驚厥(audiogenic seizure，AGS)發(fā)作狼友视频网站内容在线观看、&點(diǎn)燃&效應(yīng)以及硫酸亞鐵誘導(dǎo)的癲癇發(fā)作具有明顯的對(duì)抗作用在线看A片的网站有吗，表現(xiàn)出顯著的抗癲癇效應(yīng)。

Azo aromatic compounds exist widely in the world and millions of tons of azo compounds are produced each year.

偶氮芳香族化合物在自然界廣泛存在天天日综合网，而且每年以數(shù)百萬(wàn)噸的數(shù)量被制造出來(lái)日韩在线精品直播网站免费观看。

The absorption peaks of cyanine dye part in two compounds were bathochromic shiftsin some content because they were infected by [60]fullerene, this indicated that therewas interaction between [60]fullerene part and cyanine dye part in the compounds.

但染料部分的吸收由于受〓富勒烯的影響，在不同程度上發(fā)生了紅移美国性爱网站，這初步說(shuō)明了：〓富勒烯和染料之間有分子內(nèi)的作用亚洲综合精品。

This thesis includes five parts as follows.1. The backgrounds and some relative concepts of this work are briefly introduced. The photochemistry of benzamides and compounds with thiourea functional group is also concisely reviewed.2. Total of fourteen benzamides with different substituted groups have been synthesized and structurally characterized. Better photoreaction time for that kind of compounds at given concentrations is confirmed by tracking its'UV spectrum and GC chromatogram. A representative dibenzophenone photoproduct has been determined by X-ray crystallography. The mechanisms of photoreaction of benzamide have been proposed.3. Total of seven N-chloro(phenylmethylenebenzenamines with different substituted groups and sixty-one thiourea derivatives have been synthesized and structurally characterized.

論文的主要內(nèi)容如下：1、簡(jiǎn)要介紹本論文工作的研究背景99爱在线视频免费观看，并對(duì)苯甲酰胺和具有硫脲官能團(tuán)類(lèi)化合物的光化學(xué)研究進(jìn)展進(jìn)行簡(jiǎn)要的總結(jié)人人爽人人色人人操。2、合成與表征了14個(gè)具有不同取代基的苯甲酰胺類(lèi)化合物国产东北老妓女视频在线，利用紫外光譜和氣相色譜確定了此類(lèi)化合物較佳光照時(shí)間一级A片C视频，測(cè)定了一個(gè)具有代表性光解產(chǎn)物的單晶結(jié)構(gòu)，提出了苯甲酰胺類(lèi)化合物的光反應(yīng)機(jī)理性爱影院在线。3欧美动态性爱视频图、合成與表征了7個(gè)帶有不同取代基的氯代苯甲酰亞胺中間體及61個(gè)硫脲衍生物，測(cè)定了兩個(gè)具有代表性化合物的單晶結(jié)構(gòu)。