Then Doripenem came into the market in the July ,2005. We studied the synthesis of Doripemen.Firstly, we synthesized the chemical 2 from the starting material------o-hydroxylphenylacylamine through Reformastky reaction, alkylation, Diekmann reaction, enolization, esterification and etc. Secondly, we synthesized the chemical 3 from L — hydroxylproline through the protection of carboxyl, amidogen and hydroxyl group, reduction by NaBr, SN_2 substitution and Mitsumobu reaction.

我們以水楊酰胺為起始原料日韩美女福利网址在线观看视频免费，經(jīng)Reformatsky反應(yīng)欧洲激情一区二区三区视频、烷基化、Diekmann環(huán)合天天综合色一级毛片、烯醇化国产一级免费啪啪、酯化等反應(yīng)合成雙環(huán)母核2；再?gòu)腖-羥基脯氨酸出發(fā)色色色鬼，經(jīng)酯化保護(hù)羧基人人操操操、保護(hù)氨基、保護(hù)羥基精品无码人妻遭多人侵犯Av、硼氫化還原酯得醇看久久久黄色精品视频、Sn2取代和Mitsumobu反應(yīng)等合成巰基側(cè)鏈3；最后由化合物3經(jīng)脫保護(hù)精品欧美哟哟、水解得硫醇视色网新域名，和化合物2在二異丙基乙基胺的作用下縮合，最后Pd／C催化脫保護(hù)久热精品在线视频，歷經(jīng)16步反應(yīng)最終得到產(chǎn)物多尼培南情草视频在线。

Second, using DBU as the base for enolization of propargylic esters of unsaturated acids 18e-k, we developed a tandem Ireland-Claisen rearrangement /isomerization reactions. It has been shown that the reaction sequence affords triene molecules 42a-b and 43a-b in moderated to high yields. Interestingly, with allyl hexa-3,5-dienoates 18i-j as the substrate, the rearranged products underwent further aromatization to give uniquely substituted benzyl acids 44a-b.

其次，以含有活潑質(zhì)子的烯酸炔丙酯18e-k為底物，在DBU為烯醇化堿天天操天天怕天天日天天、TMSCl為硅試劑的條件下国产99r视频精品免费观看，底物18e-h發(fā)生了Ireland-Claisen重排/異構(gòu)化串聯(lián)反應(yīng)，得到完全共軛的三烯類化合物42a-b及43a-b国内外激情视频在线播放；而以己二烯酸炔丙基酯18i-j為底物時(shí)黑丝美女被强奸网站，重排/異構(gòu)化后的產(chǎn)物進(jìn)一步發(fā)生電環(huán)化等反應(yīng)最終得到芳構(gòu)化產(chǎn)物——取代苯甲酸類化合物44a-b。

We researched on the prepartion of pivotal intermediate 2 and 3 for 1 P-methyl carbapenem antibiotics from intermediate 1, which is subjected to Reformastky reaction, N-alkylation, Dieckmann-type cyclisation, enolization, ester condensation etc. in sequence. The synthesis route of document is optimized by us.

我們研究了1β-甲基碳青霉烯類重要中間體的合成狼友在线免费，從中間體1出發(fā)經(jīng)Reformastky反應(yīng)一级啊啊啊大舒服免费观看视频、水解反應(yīng)合成出中間體2；經(jīng)Reformastky反應(yīng)九九线精品视频、烷基化亚洲视频小说、Dieckmann環(huán)合、烯醇化我把姪女日出水了在线看、酯化合成出中間體3免费播放人成视频网站，并對(duì)其中各步反應(yīng)作了優(yōu)化和探索。

The second synthetic strategy commenced from butane-1,4-diol 50, which underwent monobenzylation, Swern oxidation, enolization followed by acetylation and debenzylation to yield an intermediate 46 in an overall yield of 54% in a 4-step procedure.

第二條路線從1女生精黄色网站，4-丁二醇50開(kāi)始色色色色色色色色色播播，這個(gè)化合物經(jīng)過(guò)單芐基化、Swern氧化免费人成网站视频在线观看、烯醇化隨后乙跞夥言谙吖劭匆患镀化和脫芐基化共4步反應(yīng)得到中間體46，總產(chǎn)率54％久久国产精品久久久久久。

We studied DBU-mediated Ireland-Claisen rearrangement. Using DBU as the base for enolization of allylic esters of unsaturated acids 9-16, we found a novel DBU-mediated tandem Ireland-Claisen rearrangement /isomerization reactions and established a consecutive Ireland-Claisen rearrangement /Cope rearrangement.

利用DBU作為烯醇化堿殴美日韩无码人妻专区，對(duì)含有活潑質(zhì)子的烯酸烯丙酯類化合物9-16的Ireland-Claisen重排進(jìn)行了系統(tǒng)的研究，創(chuàng)建了一條新穎的DBU-促進(jìn)的Ireland-Claisen重排/異構(gòu)化串聯(lián)反應(yīng)及Ireland-Claisen重排/Cope重排的串聯(lián)反應(yīng)路線精品视频三级片。

Other methyl nucleophiles includingMeMgBr, MeCeCl2, MeTiCl3, Me3Al, Me3ZnMgCl, MeMnClwere tried, but in all these cases no detectable amount of exo-C8-methylated product was obtained. Although protecting C3-carbonyl as 1,3-dioxolanes could be achieved, the serious enolization of C8-carbonyl was still problematic. Converting C9-furan ring to α,β-butenolide did depress the enolization, but desired C8-methylation was completely replaced by migration of the double bond of the butenolide.

在本論文的早期階段免费的美女色视频网站A，主要著眼于解決二環(huán)[3.2.1]-C8-羰基加成甲基所遇到的C9-呋喃環(huán)差向異構(gòu)化和C3與C8兩個(gè)羰基之間化學(xué)選擇性的問(wèn)題：通過(guò)引入不同金屬降低甲基試劑的堿性并沒(méi)有取得甲基化的成功；通過(guò)不同的方法將C3-羰基掩蔽巨乳在线播放视频，但是C8-羰基的烯醇化依然無(wú)法抑制狠狠干天天色；雖然通過(guò)將呋喃環(huán)轉(zhuǎn)化為α，β-不飽和-γ-丁內(nèi)酯可以抑制烯醇化国产鲁鲁精在线，但內(nèi)酯環(huán)上的雙鍵遷移又成了新的競(jìng)爭(zhēng)反應(yīng)gogo国模啪啪人体。