The in vivo antiaging activity of genistein can be improved by increasing the solubility and permeability of genistein.

以溶解度及滲透系數(shù)為指標改善染料木素的小腸吸收能夠改善它的體內抗衰老活性亚洲欧美日韩色图。

The genistein and glucuronidated genistein in plasma and in different tissues were detected by a high performance liquid chromatography ashy.

用反相高效液相色譜法測定不同時間大鼠血漿中原型藥物爱爱天堂网、β-葡萄糖醛酸結合型藥物及組織器官中藥物的濃度什么网站可以免费看A片。

Objective: The purpose of our studies are gaining a better insight into the effect of genistein on mesangial cell"s phenotype change and ECM expression plus degradation under DN circumstances.We add genistein with different concentrations in high glucose cultured rat mesangial cells;feed DM rats with the single concentration genistein for different days;to explore the expression of SMemb,the mark of mesangial cell"s hypertrophy phenotype change;to examine the synthesis of Fn as well as the change of the balance between MMP-2 and TIMP-l;to comprehend its effect on renal pathological changes of DM rats and some related factors;trying toexplore the possible mechanisms.Through these studies,we will have some information about the experimental value of genistein in DN field.

目的：為了研究金雀異黃素對DN環(huán)境下大鼠MC肥大表型轉換標志物SMemb和ECM分泌及降解的影響国产精品美女久久久久AV，我們擬在細胞水平以不同濃度的金雀異黃素作用于高糖培養(yǎng)下大鼠MC国产在线观看黄A片免费网站，在動物水平以同一濃度的金雀異黃素作用于DM大鼠不同時間2018偷拍视频，觀察細胞表型轉換標志物SMemb、ECM主要成分Fn欧美一级免费、ECM降解酶系統(tǒng)基質金屬蛋白酶—2(MMP-2)／基質金屬蛋白酶抑制劑—1(TIMP-1)表達的變化欧美野外打野战A片视频，同時觀察金雀異黃素對DM大鼠腎臟病理及影響腎臟病進展的糖脂代謝紊亂的影響，并進一步探討金雀異黃素發(fā)揮作用的可能機制黄色网站高潮视频免费观看；為明確金雀異黃素在DN治療中的地位及意義提供實驗依據(jù)玖玖玖无码视频。

Compare with other flavonoid the inhibition effect of Luteolin is better than Quercetin and Genistein.

并且與其他類黃酮化合物比較Luteolin的抑制效果更勝於大眾所熟知的抗氧化免费黄色网址久久、抗癌物質物質Quercetin、Genistein日本黄色视频日本黄色视频。

Studies also indicated that genistein exsists not only in soybeans but also in many kinds of plants such as vegetables and fruits.As a potential anticancer agent, the actional mechanisms of genistein mainly includes as follows:First, genistein can depress the activity of protein tyrosine kinase and transduction pathways for the phosphorylation of receptors and mitosis signal. So genistein can lead to cells' proliferation depressed. Second, genistein has minimal effects of phytoestrogens. It can be combined with estrogen receptor and improve the synthesis of cellular sex hormone binding glulobin, and improve the activity of UDP-glucuronyl transferase. Through these pathways, it can inhibit the cell activity of breast cancer and prostate cancer.

作為一個很有潛力的抗腫瘤物質久久久久久久久久久久久，三羥異黃酮的作用機制主要包括：①抑制蛋白酪氨酸激酶活性，可阻抑PTK引起的受體磷酸化和有絲分裂的信號傳遞jiZZZ3，導致癌細胞增殖受抑欧美性a爱视频；②弱雌激素作用：可通過與體內雌激素受體結合，并可增加細胞內性激素結合球蛋白的合成色哟哟AV在线播放，增加UDP-葡糖醛酸轉移酶的活性等途徑抑制乳腺癌和前列腺癌細胞活性免费观看一级A片在线视频；③拓撲酶Ⅰ和Ⅱ抑制劑，抑制細胞活性国产精品无码AV片；④上調細胞周期性負性調節(jié)因子P21WAF1/CIP1的表達美国黄片免费观看，使之負性調節(jié)因子作用增強；⑤可阻止胰島素樣生長因子-Ⅰ亚洲国产女人AAA毛片在线、肝細胞生長因子和神經(jīng)生長因子的作用而抑制腫瘤生長羞羞漫画在线观看巨黄；⑥其他：抗氧化作用、抑制熱休克蛋白女18毛片亚洲一级毛片、誘導細胞凋亡91av在线观看91、抑制新生血管生成和抑制多種耐藥相關蛋白等。

The ventilatory responses of peripheral chemoreflex following 0.1 m l microinjection within the NTS of either PTK inhibitor genistein(10 mol/L), AMPA glutamate receptor inhibitor CNQX (10 mol/L),or inactive PTK inhibitor daidzein (10 mol/L) were recorded.

在孤束核處分別微量注射蛋白酪氨酸激酶的抑制劑genistein和其非活動性抑制劑daidzein 以及 AMPA受體阻斷劑CNQX玖玖国产精品视频，觀察這些藥物對外周化學感受性反射的影響最新无码专区视频在线。

The effect of genistein (0.8 mg/kg) was partially inhibited by L-NAME, or by sodium orthovanadate (50 μg/kg), a potent inhibitor of protein tyrosine phosphatase;(2) genistein also decreased the PP of renal vascular bed in a dose-dependent manner and the effect of genistein was completely inhibited by pretreatment with sodium orthovanadate, but unaffected by L-NAME; and (3) genistein decreased the PP of mesenteric vascular bed in a dose-dependent manner, an effect which was partially inhibited by sodium orthovanadate, but unaffected by L-NAME.

GST的這一效應可被L-硝基精氨酸甲酯部分阻斷，預先注射蛋白酪氨酸磷酸酶抑制劑正釩酸鈉(50 μg/kg)黄页在线免费观看色秀，可部分抑制GST (0.8 mg/kg)引起的效應欧美在线视频首页；(2)向腎血管灌注環(huán)路中直接注射 GST 也可劑量依賴性地降低腎動脈的灌流壓，預先注射正釩酸鈉可完全抑制GST引起的效應永久在线精品免费播放，而L-NAME對此效應沒有影響一级a作爱在线视频观看；(3)腸系膜血管灌流環(huán)路中注射GST可劑量依賴性地降低其灌流壓，這一效應可被正釩酸鈉部分抑制欧美女肏屄，而L-NAME對此無影響日韩一级A片在线高清视频。

Mg/ kg way partially inhibited by L- NAME,or by sodium orthovanadate(50 ug/ kg),a potent inhibitor of protein tyrosine phosphatase;(2)genistein also decreased the PP of renal vascular bed in a dose-dependent manner and the effect of genistein was completely inhibiteby pretreatment with sodium orthovanadate,but unaffected by L- NAME;and(3 genistein decreased the PP of mesenteric vascula bed in a dose-dependent manner,an effect which was partially inhibited by sodium orthovanadate,but unaffected by L- NAME .

mg/ kg引起的效應；(2)向腎血管灌注環(huán)路中直接注射GST也可劑量依賴性地降低腎動脈的灌流壓又爽又刺激的视频网站，預先注射正釩酸鈉可完全抑制GST引起的效應欧美熟妇人妻BBBBBⅩXXXX，而L- NAME對此效應沒有影響；(3)腸系膜血管灌流環(huán)路中注射GST可劑量依賴性地降低其灌流壓欧美午夜三级片，這一效應可被正釩酸鈉部分抑制午夜视频你懂的，而L- NAME對此無影響。

The effect of genistein (0.8 mg/kg) was partially inhibited by L-NAME, or by sodium orthovanadate (50 μg/kg), a potent inhibitor of protein tyrosine phosphatase;(2) Genistein also decreased the PP of renal vascular bed in a dose-dependent manner. The effect of genistein was completely inhibited by pretreatment with sodium orthovanadate, but unaffected by L-NAME;(3) Genistein decreased the PP of mesenteric vascular bed in a dose-dependent manner, an effect which was partially inhibited by sodium orthovanadate, but unaffected by L-NAME.

GST的這一效應可被L-硝基精氨酸甲酯部分阻斷亚州黄色专区毛毛片，預先注射蛋白酪氨酸磷酸酶抑制劑正釩酸鈉(50 μg/kg)永久免费视频在线观看色黄，可部分抑制GST (0.8 mg/kg)引起的效應婷婷五月丁香在线；(2)向腎血管灌注環(huán)路中直接注射 GST 也可劑量依賴性地降低腎動脈的灌流壓，預先注射正釩酸鈉可完全抑制GST引起的效應99精品综合加勒比在线观，而L-NAME對此效應沒有影響亚洲欧美色图13p；(3)腸系膜血管灌流環(huán)路中注射GST可劑量依賴性地降低其灌流壓，這一效應可被正釩酸鈉部分抑制欧洲免费AV在线网站观看，而L-NAME對此無影響国产综合视频网。

PartⅠGenistein thwarts the development ofatherosclerosis in LDLR-knockout mice BACKGROUND: Artherosclerosis and its complication are one of the maincauses for pathopoiesis and death.

第一部分Genistein對LDLR-／-小鼠動脈粥樣硬化發(fā)生發(fā)展的影響研究背景動脈粥樣硬化(artherosclerosis，AS)及其并發(fā)癥是人群致病和死亡的重要原因之一国内妇人成熟A片免费看。