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In particular, it is unknown how the relevant neural substrates function as a network to mediate perspective-taking during the task requiring understanding other's belief. The current work first developed a new psychological paradigm that excludes potential confounds such as the processing of language, biological motion, episodic memory and causal coherence in the paradigms used in previous studies. I recorded neural activities associated with mental inference task using functional magnetic resonance imaging and electroencephalography in order to investigate the functional roles of several brain areas (i.e. precuneus, MPFC, etc.) that engage in understanding other's belief. I also proposed a computational model based on the neuroimaging results that simulated the neurocognitive mechanism underlying cortical dynamics in correct judgment of other's belief.

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The transition from the systemic inflammatory response syndrome to seere sepsis and septic shock inoles a myriad of pathogenic changes, including circulatory abnormalities that result in global tissue hypoxia.1,2 These pathogenic changes hae been the therapeutic target of preious outcome studies.12 Although this transition occurs oer time, both out of the hospital and in the hospital, in outcome studies interentions hae usually been initiated after admission to the intensie care unit.12 In studies of goal-directed hemodynamic optimization, in particular, there was no benefit in terms of outcome with respect to normal and supranormal hemodynamic end points, as well as those guided by mixed enous oxygen saturation.9,13 In contrast, een though we enrolled patients with lower central enous oxygen saturation and lower central enous pressure than those studied by Gattinoni et al.9 and with a higher lactate concentration than those studied by Hayes et al.,13 we found significant benefits with respect to outcome when goal-directed therapy was applied at an earlier stage of disease.

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Though the Waddington and von Bertalanffy programs have not been confirmed in the typical accomplishments and representations in molecular biology in general, and molecular genetics in particular, there are interesting advances that fall between those searches for broad theories couched in mathematically precise differential equation form, and the narrow classes of mechanisms, usually described in qualitative multilevel causal language, that constitute the vast majority of current biomedical explainers.

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