Background and objective Although marked progress has been made in the treatment of acute myeloid leukemia,about 20%～40% patients with AML failed to get complete remission after standard induction chemotherapy. Furthmore, approximate 70% patients in CR will die because of relapse or refractory to therapy during post remission chemotherapy.

研究背景及目的：盡管目前急性髓系白血病(acute myeloid leukemia，AML)的治療取得了顯著的進(jìn)步鸥美多人××视频，但仍有20％～40％的患者經(jīng)標(biāo)準(zhǔn)誘導(dǎo)治療未能達(dá)到完全緩解(complete remission淫荡视频网址，CR)，即使獲得CR的患者纯A级黄毛片一级，在鞏固化療后仍有70％左右復(fù)發(fā)或發(fā)展為難治性急性髓系白血病而治療無效死亡永久黄网站色视频免费观看w下载。

BMI-1(B-cell-specific Moloney murine leukemia virus integration site 1), a Polycomb group repressor, is always present as a PcG complex combined with RING1, HPC2, Mph2, et al. BMI-1 prolongs cells'capacity to proliferate and represses their senescence by repressing the transcription of CDKN2A through acetylhydrolasing or deacetylhydrolasing the Polycomb response elements in chromosome.

BMI-1 (B-cell-specific Moloney murine leukemia virus integration site 1)屬于PcG家族，它與該家族其他成員如RING1国产一级A片a爱视频，HPC2看美女被操的平台免费观看，Mph2等結(jié)合形成蛋白復(fù)合體，作用于染色質(zhì)PREs位點(diǎn)中文字幕第页日，通過對組蛋白進(jìn)行乙跖访谰稟AAAAAAAA片；腿ヒ阴欧美国产欧美日韩；揎梬wwxxxx黄色，從而穩(wěn)定抑制CDKN2A轉(zhuǎn)錄，最終促進(jìn)細(xì)胞的增殖并抑制細(xì)胞凋亡尹人手机在线视频。

The mouse embryonic stem cells cDNA library was screened by yeast two-hybrid assay,some candidate molecules were get,including DDX39 DEAD (Asp-Glu-Ala-Asp box polypeptide 39, BAT1A(HLA-B-associated transcript 1A), NAC1 ( nucleus accumbens-1 ), BicD2 (bicaudal D homolog 2)国产黄色无码、MLL3 (myeloid/lymphoid or mixed-lineage leukemia 3). NAC1 and MLL3 were associated with regulation of gene transcription. DDX39 andBAT1A were associated with pre-mRNA processing and mRNA export from nucleus to cytoplasm. BicD2 was associated with the regulation of Golgi body.

通過利用酵母雙雜交方法，以小鼠全長Plk1作為誘餌蛋白篩選小鼠胚胎干細(xì)胞cDNA文庫中與其相互作用的蛋白亚洲一区二区在线观看免费视频，獲得了DDX39DEAD(Asp-Glu-Ala-Aspbox polypeptide 39一级A片黄片免费视频、BAT1A(HLA-B-associated transcript 1A)、NAC1(nucleus accumbens-1)国产另类自拍、BicD2(bicaudal D homolog 2)怡红院性爱网、MLL3(myeloid／lymphoid or mixed-lineage leukemia 3)等幾個(gè)候選蛋白，其中NAC1男人干男人的黄色视频、MLL3與基因的轉(zhuǎn)錄調(diào)控有關(guān)手机在线一区二区三区免费视频视频，DDX39、BAT1A與mRNA前體的剪切、加工及mRNA從細(xì)胞核轉(zhuǎn)運(yùn)到細(xì)胞質(zhì)緊密相關(guān)国产精品免费一级高清不卡，而BicD2與高爾基體的調(diào)控緊密相關(guān)美女黄色片在线免费观看，提示我們Plk1與基因轉(zhuǎn)錄、mRNA前體的剪切99riAV无码、加工性欧美XXXX一XXXX极品、mRNA的運(yùn)輸及胞質(zhì)分裂中高爾基體的調(diào)控有關(guān)。

To explore the expressions of the intercellular adhesion molecule3（ICAM3） in acute leukemia and to investigate its role in clinical therapeutic efficacy and extramedullary infiltration.

目的 探討細(xì)胞間粘附分子3(intercellular adhesion molecule397资源人人干，ICAM3)在急性白血不粕?1在线国产。╝cute leukemia，AL）中的表達(dá)及其在臨床療效97国产精品一区在线播放、髓外浸潤中的意義免费看污网站十八禁永久免费。

Objective To explore the expressions of the inter-cellular adhesion molecule-3 (ICAM-3) in acute leukemia and to investigate its role in clinical therapeutic efficacy and extramedullary infiltration.

目的 探討細(xì)胞間粘附分子－3(inter-cellular adhesion molecule-3， ICAM-3)在急性白血病(acute leukemia免费黄片wwwwww， AL)中的表達(dá)及其在臨床療效野花社区wwW日本最新免费观看、髓外浸潤中的意義。

To explore the expressions of the intercellular adhesion molecule-3（ICAM-3） in acute leukemia and to investigate its role in clinical therapeutic efficacy and extramedullary infiltration.

目的探討細(xì)胞間粘附分子-3(intercellular adhesion molecule-3激情亚洲欧美日韩在线观看网站，ICAM-3)在急性白血补肪镁?9囯产精品久久国。╝cute leukemia，AL）中的表達(dá)及其在臨床療效国产亚洲视屏、髓外浸潤中的意義欧美成年人片。

Results Among the 104 primary acute leukemia patients, the number of patients with T lymphocyte leukemia,B lymphocyte leukemia,acute myeloblastic leukemia,mixed phenotype acute leukemia and umclassified leukemia were 4(3.8％),38(36.5％),58(55.8％),2(1.9％),and 2(1.9％),respectively.

結(jié)果 104例初發(fā)急性白血病中，T淋巴細(xì)胞白血病4例(3.8％)66J8在线视频免费看，B淋巴細(xì)胞白血病38例(36.5％)日韩精品国语在线观看视频免费，急性髓細(xì)胞白血病58例(55.8％)，急性混合性白血病2例(1.9％)大屁股91，未行明確分類的2例(1.9％)r日本在线h。

Results among the 104 primary acute leukemia patients, the number of patients with t lymphocyte leukemia,b lymphocyte leukemia,acute myeloblastic leukemia,mixed phenotype acute leukemia and umclassified leukemia were 4(3.8％),38(36.5％),58(55.8％),2(1.9％),and 2(1.9％),respectively.conclusion detecting immune marker on leukemic cell by abc-ap two step immune method is very simple which can be finished with a light microscope,and it can provide a reliable basis for the diagnosis and classification of leukemia and even the targeting therapy for leukemia.

結(jié)果 104例初發(fā)急性白血病中，t淋巴細(xì)胞白血病4例(3.8％)久久亚洲精品无码a∨，b淋巴細(xì)胞白血病38例(36.5％)中文字幕一区2区，急性髓細(xì)胞白血病58例(55.8％)，急性混合性白血病2例(1.9％)国产特级黄色操逼毛片，未行明確分類的2例(1.9％)快射视频十八禁网站。結(jié)論 abc-ap免疫二步法檢測白血病細(xì)胞免疫標(biāo)記方法簡單，只須普通光學(xué)顯微鏡就能開展實(shí)驗(yàn)少妇被又大又粗进进出出，可為白血病的診斷国产一级毛片视频无码网站、分型、分類乃至白血病靶向治療提供可靠依據(jù)免费xx视频。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

緒論 絕大多數(shù)的嬰兒白血病亚洲毛片av男人的天堂，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色體11q23部位有染色體易位的情況；這個(gè)部位的染色體易位牽連了混合譜系白血病基因国产偷窥真人视频在线观看。大多數(shù)具有MLL基因重排的兒童白血病潛伏期明顯短很多美女裸体黄18禁网站。MLL基因重排也和經(jīng)拓?fù)洚悩?gòu)酶II抑制劑治療后的繼發(fā)性白血病有關(guān)。這些繼發(fā)性白血病的潛伏期類似地都非常的短老外肏中国女人屄HD。很重要的是精品无码麻豆AV福利网，單卵雙胞胎嬰兒同時(shí)患有或同時(shí)免于MLL基因重排陽性的白血病的一致性接近100%；并且同樣患有ALL的同卵雙胞胎的MLL基因的斷裂點(diǎn)是一致的性欧美首页。而且肏穴视频在线观看，這種獨(dú)特的克隆特異性的MLL融合基因能夠從那些得ALL的非雙生個(gè)體出生時(shí)的血斑標(biāo)本中檢測到。這些發(fā)現(xiàn)表明MLL融合基因產(chǎn)生在胎兒還在子宮的是后激情自拍网一区2区，而且MLL融合蛋白能過和其他的基因突變一起誘導(dǎo)白血病的產(chǎn)生A,黄片免费视频。Greaes 等推測MLL融合蛋白在某種情況下同過快速克隆增殖，遺傳的不穩(wěn)定性或是DNA損傷修復(fù)的抑制促使疾病迅速地全面爆發(fā)国产一级A片A视频。惡性腫瘤細(xì)胞的克隆增殖通常已經(jīng)獲得了逃避機(jī)體免疫監(jiān)視的能力国产专区一。免疫逃避機(jī)制也歸因于異體外周血干細(xì)胞移植后移植物抗白血病作用的失效。所以熟女屁眼，白血病細(xì)胞在白血病的產(chǎn)生過程中可能獲得了某些免疫逃脫機(jī)制五月丁香六月婷综合综合久久。

The condition was attributed presumptively to infection with Abelson's murine leukemia virus.

此狀況推測乃由於 Abelson 小鼠白血病病毒(Abelson's murine leukemia virus)感染所致。