Results:There were no abdominal pain and fever,jaundice faded away gradually postoperation.Biliary drainage was 300ml-1000ml/d more or less.Colour of bile changed into normal by degrees.Intra peritoneal drainage was open and the colour was light bloody.Amount of drainage dropped off day after day.Whole blood cell test, serum glutamic pyruvic transaminase,serum glutamic oxalacetic transarninase,total serum protein,serum albumin and serum globulin returned to normal in first week postoperation.Serum bilirubin,serum glutamyltranspetidase and serum alkaline phosphatase declined gradually in first week postoperation.T-tube was clipped at twelfth day postoperation.T-tube Cholangiography was clear at 24~ day postoperation.

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The activity of glutamate-pyruvate transaminase andglutamic oxalacetic transaminase was measured using AU5400 automaticbiochemical analyzer; the activity of the hyaluronic acid,the laminin,precollagen typeⅢ type, collagen typeⅣ was evaluated according toradioimmunoassay method; the activity of transforming growth factor beta-1(TGFβ1)and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) was measured according to enzyme linked immunosorbent assay. Results First, the effect of Baoganning on CCL_4 induced hepatic fibrosis in rats.

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Pharmacodynamics experiments indicated that the drug obviously degraded the content of Cholesterol,Triglycerides,glutamic pyruvic transaminase and Maleic Dialdehyde in the Alcoholic fatty liver of rats and mice treated with by oral administration, it also degraded the content of glutamic oxalacetic transaminase, r-GLU,alkaline phosphatase and increased the content of Albumin and Superoxide Dismutase in the Alcoholic fatty liver of rats, and remarkably reduced depressant effect of the mice'centra nerve.

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However,the glutamic-pyruvic transaminase and the glutamic-oxalacetic transaminase activities of the grass carp serum in soybean group are significantly higher than that of the 4 groups. The hematoglobin concentration of the grass carp in fish group are significantly higher than that of the 4 groups.

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