Clonal anergy and suppressor cells are main mechanisms of the tolerance.

克隆不應(yīng)答和抑制細(xì)胞是耐受的主要機(jī)制。

Methylation of CpG islands in the promoters induces gene silencing. The multiple tumor suppressor gene P16, located at chromosome 9p21, regulating normal proliferation of cells with a functional unit constituting of p16, cyclin D1 and pRb together. Methylation of P16 gene has been detected in several lymphocytic and plasmacytic malignancies such as lymphoma, acute lymphocytic leukemia and multiple myeloma and shows relationships with the pathogenesis of these diseases. Application of demethylation agents or arsenical to refresh the gene functions will be expected to be a new treatment for hemopoietic malignancies.

基因啟動子區(qū)CpG島甲基化常導(dǎo)致基因沉默。P16基因是一定位于9p21的多種腫瘤抑制基因，通過pl6INK4Acyclin D1-PRb通路維持機(jī)體細(xì)胞的有序增殖。P16基因甲基化在淋巴瘤嗯a操我视频、急性淋巴細(xì)胞性白血病、多發(fā)性骨髓瘤等多種淋巴細(xì)胞漿細(xì)胞腫瘤中被檢測到免费丝袜美女一级A片，并與疾病的發(fā)生亚洲黄色视视频、發(fā)展存在一定關(guān)系，應(yīng)用甲基化抑制因子或砷劑去甲基化治療嗯啊哈轻点无码视频，恢復(fù)基因功能可望成為血液惡性腫瘤治療的一種新手段xxxx黄色小视频。

The effect of the suppressor on the determination of cations was studied and the relationship between response conductivity of cations and suppressor current intensity was discussed.

探討了離子抑制反應(yīng)對陽離子測定的影響以及陽離子響應(yīng)電導(dǎo)和抑制電流強(qiáng)度的關(guān)系。

Mutants related to shoot branching are isolated in pea? Arabidopsis? petunia? rice? tomato and maize, such as revoluta? pinhead? monoculm1(moc1)? lateral suppressor? blind/torosa related to axillary meristem initiation; more axillary growth? ramosus? decreased apical dominance associated with axillary meristem outgrowth; supershoot/bushy? Teosinte branched1 (Tb1) contacted with axillary meristem initiation and outgrowth.

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The big difference between these two alternatie ways that tumour cells use to inactiate tumour suppressor genes is that, while the reersal of genetic alterations is technically almost unfeasible in clinical scenarios, the function of these epigenetically inactiated suppressor genes is easily reactiated by pharmacological means.

這兩種改變方式最大的不同之處在于腫瘤細(xì)胞利用失活的腫瘤抑制基因，而在同時(shí)相反的遺傳學(xué)改變在臨床方案上是很難實(shí)施的技術(shù)特级欧美淫秽视频展播。

To study the regulation mechanism of SOCS-3 (Suppressor of cytokines signals-3) for erythropoietic development, small interference RNA expression vectors of SOCS-3 were constructed and transferred in to the K562 cell lines stably by lentiviral system.

為了研究細(xì)胞因子信號轉(zhuǎn)導(dǎo)分子3(suppressor of cytokine signals-3欧美日韩另类日韩另类在线，SOCS-3)對造血發(fā)育的影響，構(gòu)建了SOCS-3慢病毒siRNA干涉載體，并轉(zhuǎn)染人紅白血病細(xì)胞株K562国产一区二区三区美女。

The resulting strain, designated YES2MTM1, was transformed with a yeast genomic library. Transformants lost the plasmid overexpressing MTM1 after 5-FOA treatment. Yeast strains able to grow on nonfermentable carbon source with MTM1 deletion and overexpression of some DNA fragments were picked up and candidate suppressor genes were identified. Overexpression of five genes were identified to be able to rescue the growth defect on nonfermentable carbon source. The study will provide reference for MTM1 gene function and screening for suppressor of genes whose deletion result in irreversible damage.

為了避免MTM1缺失造成的不可逆損傷黑大粗高潮视频在线观看，在野生型酵母中先轉(zhuǎn)入帶有MTM1 基因的質(zhì)粒，再敲除染色體上的MTM1 基因午夜狼友啪啪视频，隨后轉(zhuǎn)入基因組文庫wwwjizzcom，再利用藥物5-氟乳清酸(5-FOA)迫使細(xì)胞丟失表達(dá)MTM1基因的外源質(zhì)粒，再篩選能在非發(fā)酵培養(yǎng)基上生長的轉(zhuǎn)化子中文无码AV天天爽无遮挡，通過這種方法篩選發(fā)現(xiàn)亚洲视频乱伦专区，POR2等5個(gè)基因的過表達(dá)可以挽救MTM1 基因缺失造成的非發(fā)酵培養(yǎng)基上的生長缺陷，為深入了解MTM1基因的功能提供了線索美女被狂操到高潮视频网站，對篩選其他造成不可逆損傷的突變基因的抑制基因提供了一條可行的研究思路欧美一区二区三四在线观看。

To obtain more information of magnesium homeostasis in mitochondria, mTn-lacZ/LEU2 transposon library was transformed into mrs2 deletion mutant to screen for suppressor genes of MRS2. YMR166C, a member of mitochondrial carrier family, was identified as a suppressor gene of MRS2. Deletion of YMR166C gene can rescue the defects of mrs2 deletion mutant such as the decrease in mitochondrial magnesium concentration, Group II RNA splicing defect and growth defect on nonfermentable carbon source. For the first time we demonstrated YMR166C is involved in mitochondrial magnesium homeostasis.

為了增進(jìn)對線粒體鎂離子代謝調(diào)控基因的了解，利用釀酒酵母mTn-lacZ/LEU2轉(zhuǎn)座子文庫篩選MRS2的抑制基因seⅹ1级黄色，發(fā)現(xiàn)線粒體載體家族成員YMR166C基因的缺失可以挽救MRS2基因缺失的突變體的生長缺陷在线观看AAA黄片、II型內(nèi)含子剪接缺陷，并可以調(diào)節(jié)線粒體鎂離子濃度全网免费观看黄色片，首次發(fā)現(xiàn)YMR166C是線粒體鎂代謝相關(guān)基因91字幕网中文国产。

Suppressor is the key part for IC instrument, and developing a high performance suppressor for IC instrument is quite important to gradient ion chromatography, to analysis of some ions which have strong affinities with the functional groups located on the surface of the pellicular ion exchange column packing.

抑制柱是離子色譜儀的一個(gè)核心部件，研制具有較高抑制容量的抑制柱對于離子色譜法的梯度淋洗日韩人妻A级毛片、對于在分離柱上保留時(shí)間長的離子分析具有重要的意義国产一级A片无码免费视频一。

Part-3 Tumor Suppressor Gene PTEN Up-regulates p53 Level and Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Objective: To investigate the effects and the mechanisms of tumor suppressor gene PTEN on level of p53 protein and sensitivity of HepG〓 cells to chemotherapy.

第三部分 PTEN在肝癌細(xì)胞中上調(diào)p53蛋白水平并增強(qiáng)化療藥物敏感性目的：研究抑癌基因PTEN對肝癌細(xì)胞化療藥物敏感性及p53蛋白水平的影響，并探討相關(guān)機(jī)制久久99con。