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The results are as follow:(1) During the IR, heart rate, arterial blood pressure and myocardial oxygen consumption are decreased progressively. The epicardial electrographic ST-segment is elevated significantly during ischemia (P＜0.001) and recovers to baseline during reperfusion.

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The results are as follow:(1) During the MIR, heart rate, arterial blood pressure, and myocardial oxygen consumption are decreased progressively. The epicardial electrographic ST-segment is elevated significantly during ischemia (P＜0.001) and recovers to baseline during reperfusion.

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This paper aims at the study of the toxic mechanism of gelsemium total alkaloids ,i.e. their impacts on respiration,heart rate and blood pressure by 5 different concentrations(0.5,1.0,2.0,4.0,8.0 mg/kg).

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The National Heart, Lung, and Blood Institute; the Gustavus and Louis Pfeiffer Research Foundation; the Women's Guild of Cedars-Sinai Medical Center; and the Ladies Hospital Aid Society of Western Pennsylvania supported this study.

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