Objective To investigate the effect of butyric acid and its derivative tributyrin in combination with all-trans retinoic acid on differentiation induction of APL cells.

目的 研究丁酸類衍生物聯(lián)合維甲酸對急性早幼粒細(xì)胞白血病患者原代培養(yǎng)細(xì)胞的誘導(dǎo)分化作用一级大片黄。

Olive oil, tributyrin and p-nitrophenyl palmitate were used as substrates to measure lipase activity.

分別以橄欖油手机在线AⅤ片免费视频观看、三丁酸甘油酯和對硝基苯酚棕櫚酸酯為底物檢測展示的脂肪酶酶活。

Thus, tributyrin may be a potential chemopreventive and chemotherapeutic agent against human gastric cancer.

因此一级精品一区视频在线观看，tributyrin可能是一個非常有應(yīng)用前景的預(yù)防和治療胃癌的天然化學(xué)藥物全免一级久久久久片。

These data demonstrated that tributyrin can efficiently inhibit gastric cancer cell growth by inhibiting DNA synthesis and inducing apoptosis. The tributyrin-induced apoptosis is associated with down-regulation of Bcl-2 expression and up-regulation of Bax expression.

這些結(jié)果首次顯示tributyrin能有效地通過抑制DNA合成和誘導(dǎo)細(xì)胞凋亡達(dá)到抑制胃癌細(xì)胞生長的作用，細(xì)胞凋亡與Bcl-2表達(dá)量下調(diào)和Bax表達(dá)量上升有關(guān)视频久久这里。

The experimental diet with glutamine (10 g/kg), or with lactitol (3 g/kg), or with tributyrin (5 g/kg), or with lactitol (3 g/kg) plus tributyrin (5 g/kg), the aim is to determined effects of several several substances and compound on early weaned piglets.

整個試驗分為以下四個部分： 1 幾種物質(zhì)對早期斷奶仔豬生長性能的影響在斷奶當(dāng)天一级黄色夫妻生活a片在线免费观看、斷奶后7天、14天2020av天堂在线、21天及28天分別對仔豬進(jìn)行稱重欧美夫妻生活，觀測豬只的平均日增重、日采食量一本大道香蕉欧美精品69、料重比及腹瀉率黄A大片免费播放网站。

The expression of p-p38 and Rho GDIαwas upregulated in LCA by either low shear stress or hypertension. However, the highest expression of p-p38 and Rho GDIαwas observed in LCA of low shear stress accompanied by hypertension.(4) Effect of low shear stress on both decreasing apoptosis and increasing proliferation of VSMCs in LCA was reversed by tributyrin, a HDAC inhibitor.

當(dāng)高血壓伴有低切應(yīng)力時，兩者的協(xié)同作用誘導(dǎo)p-Akt的表達(dá)水平進(jìn)一步增加欧美图片亚州图片性爱图片自拍偷拍；(3)高血壓和低切應(yīng)力都可以誘導(dǎo)頸總動脈p38和Rho GDIα表達(dá)增加999黄色网站；當(dāng)高血壓伴有低切應(yīng)力時，兩者的協(xié)同作用誘導(dǎo)頸總動脈p38和Rho GDIα表達(dá)進(jìn)一步增加美国一级黄片A久久；(4)HDAC抑制劑Tributyrin可以通過抑制VSMCs增殖日韩精品深夜666片免费观看网站，促進(jìn)VSMCs凋亡，在干預(yù)低切應(yīng)力誘導(dǎo)的血管重建中發(fā)揮作用国产精品天堂Av妓女。

To elucidate the possible mechanism of differentiation and /or apoptosis in NB4, K562 cells induced by tributyrin, a histone deacetylase inhibitor, the level of acetylated histone H3 was detected by Western blot, p21~ WAF1expression was detected by semi-quantitative RT-PCR.

為了探討組蛋白去乙蹙镁镁靡槐靖咔迕夥眩化酶抑制劑三丁酸甘油酯(tributyrin，TB)誘導(dǎo)NB4九一在线视屏、K562白血病細(xì)胞分化和凋亡的作用機(jī)制黄色视频网址免费看，利用Westernblot方法及逆轉(zhuǎn)錄聚合酶鏈反應(yīng)檢測TB作用前后NB4、K562細(xì)胞組蛋白H3乙酰化水平以及p21WAF1表達(dá)量的改變五月天无码视频。

To elucidate the possible mechanism of differentiation and/or apoptosis in NB4, K562 cells induced by tributyrin, a histone deacetylase inhibitor , the level of acetylated histone H3 was detected by Western blot, p21(superscript WAF1) expression was detected by semi-quantitative RT-PCR.

為了探討組蛋白去乙趺磺荆化酶抑制劑三丁酸甘油酯(tributyrin， TB)誘導(dǎo)NB4五级的在线观看黄色网站、K562白血病細(xì)胞分化和凋亡的作用機(jī)制欧美大片在线免费观看，利用Western blot方法及逆轉(zhuǎn)錄聚合酶鏈反應(yīng)檢測TB作用前后NB4、K562細(xì)胞組蛋白H3乙趸埔惩反笕夥压劭?0在线；揭约皃21(上標(biāo) WAF1)表達(dá)量的改變欧美性爱人人网。

The results suggested that vascular remodeling was the most prominent in LCA subjected to low shear stress accompanied by hypertension, which is regulated through the changing expression of p-Akt, p-p38, Rho GDIα. Tributyrin could affect the flow mediated carotid remodeling by both increasing apoptosis and decreasing proliferation of VSMCs through PI-3K/Akt, bcl-2, p53, p27. Tributyrin could have potential roles in treatment of vascular diseases, such as artherosclerosis and vascular restenosis, etc.

結(jié)果提示，高血壓與切應(yīng)力協(xié)同作用對血管重建的影響最為顯著国产福利在shipin，AktAV一本大道香蕉大在线不卡、p38和Rho GDIα信號通路參與了高血壓與低切應(yīng)力誘導(dǎo)的血管重建過程；Tributyrin對血管重建的干預(yù)作用是通過影響PI-3K信號通路性爱黄色视频网，調(diào)節(jié)凋亡相關(guān)蛋白bcl-2以及細(xì)胞周期調(diào)控蛋白p53和p27的表達(dá)水平而實現(xiàn)的最新欧美性爱网址；Tributyrin有可能成為一種在動脈粥樣硬化、血管再狹窄等疾病防治中有潛在臨床應(yīng)用價值的藥物亚洲欧美中文精品。

One integrative transformant was obtained through PCR and phenotype identification, designated as A.oryzae ONL1. The 7-day fermentation broth of A.oryzae ONL1 could hydrolyze tributyrin verified by forming transparent cleared zone on tributyrin plate, and the enzyme activity reached 2.5 U/mL. The SDS-PAGE electrophoretic map of the fermentation broth demonstrated that there was a typical RML band at 32.5 kDa.

其培養(yǎng)7天的培養(yǎng)液上清在以三丁酸甘油酯為底物的平板上形成清晰的水解透明圈涩涩网页，堿滴定法酶活測定表明培養(yǎng)液酶活可達(dá)2.5 U/mL，培養(yǎng)液上清的SDS-PAGE圖譜在32.5 kDa處有RML的特征條帶在线免费观看一区。