The results show that the universal unfolding with respect to the excitation amplitude possesses codimension 3. The transition sets in unfolding parameter plane and the bifurcation diagrams are plotted under some conditions.

結(jié)果表明：關(guān)于外部激勵振幅的普適開折具有余維3女同精品一区二区三区，在某些條件下狠狠se狠狠ri91视频，得到了轉(zhuǎn)遷集及分岔圖国内久久久久久久久久精品影院。

On the basis of the kinetic equation of substrate reaction in the presence of urea or guanidine hydrochloride, all microscopic kinetic constants for the free enzyme and enzyme-substrate binary and ternary complexes have been determined. The results of the present studies indicate that:①In the presence of urea or guanidine hydrochloride, enzyme-substrate complexes lose their activity less rapidly than the free enzyme. Therefore, both substrates, NADPH and 7, 8-dihydrofolate, protect dihydrofolate reductase against inactivation.②The denaturation of dihydrofolate reductase by urea follows single-phase kinetics, and changes in enzyme activity and tertiary structure proceed simultaneously in the unfolding process, so it may be an"all or none"process.③The GdnHCl-induced unfolding of the dihydrofolate shows a biphasic transition, while the change in the enzyme activity is a single exponential process. The rate constant of inactivation is consistent with that of the fast conformational change. Therefore, the kinetic intermediate of protein unfolding should be a partially folded and inactive form.

我們根據(jù)在脲或鹽酸胍存在下的底物反應(yīng)動力學(xué)方程求得游離酶和酶底物二元亚洲中文字幕无码乱线、三元復(fù)合物的微觀動力學(xué)常數(shù)国内自拍第十六页日韩在线观看，結(jié)果表明：①酶-底物二元一区高清精品视频在线观看、三元復(fù)合物的失活速度明顯慢于游離酶，說明兩個底物二氫葉酸和NADPH對酶的失活都具有一定程度的保護(hù)作用；②在脲作用下男人和女人做视频毛片，酶的失活和構(gòu)象變化均為單指數(shù)項(xiàng)過程插插插视频，而且酶的活力喪失和三級結(jié)構(gòu)變化是同時發(fā)生的，說明二氫葉酸還原酶的脲變性可能是一個"全或無"的兩態(tài)過程黄色α片；③在鹽酸胍作用下在线视频A片，酶的構(gòu)象變化為兩相過程，而失活則是單指數(shù)項(xiàng)過程人人干全免费黄色视频，酶分子構(gòu)象變化的快相速度常數(shù)與失活速度常數(shù)基本一致色色色丝袜，因此我們認(rèn)為二氫葉酸還原酶的鹽酸胍變性過程中存在一個沒有活力、但仍具備一定空間結(jié)構(gòu)的變性中間體狼色精品中文字幕在线视频。

The unfolding processes of the typical two-domain proteins are discussed in more details. Under certain conditions, the double sigmoidal curve of two-domain protein can be accounted for. At the same time, some expectations for several different unfolding processes are made.

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And still be it all, unfolding, unfolding...

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Results show that the unfolding of TIM is highly cooperative and no folding intermediate was detected in the experimental conditions used. The thermodynamic parameters of TIM during guanidine denaturation were calculated according to a two-state unimolecular unfolding model.

結(jié)果表明国产99，用不同測量方法得到TIM的變性過程均高度協(xié)同黄色视频A级毛片，沒有觀察到折疊中間態(tài)，應(yīng)用單分子二態(tài)去折疊模型計(jì)算了TIM去折疊的熱力學(xué)參數(shù)亚洲无码啪啪啪网站。

Moreover, the stability of unfoldings of such kind of bifurcation problems is discussed, and the sufficient condition of an unfolding of a bifurcation problem to be stable is that it is versal unfolding under certain conditions.

得到的這種分歧問題的無窮小穩(wěn)定與穩(wěn)定是等價的精品美乳日韩视频，而且討論了這種分歧問題開折的穩(wěn)定性，得到了一定條件下分歧問題開折穩(wěn)定的充分必要條件為該開折是通用開折黄色网站免费看入口。

The versal unfolding theorem obtained in this paper by using DA-algebras tools introduced by Damon not only includes many corresponding results but also cancels the stronger demand on the codimension of a bifurcation Problem in some of relevant references to establish more general unfolding theory.

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Molecular dynamics simulation has been used to investigate the force-induced unfolding of mesophilic cold shock protein, finding that the unfolding process occur through intermidate states.

當(dāng)使用機(jī)械力對嗜溫冷休克蛋白進(jìn)行拉伸研究時国产女做a性色精品视频免费，發(fā)現(xiàn)嗜溫冷休克蛋白的去折疊過程具有明顯的中間態(tài)。

The chromatin unfolding assay showed that ,like the wild-type transactivation domain, two variants that represent benign polymorphisms did not induce chromatin unfolding or only induced subtle change. Contrary to the behaviors of the wild type and two benign variants, four cancer-predisposing mutations in the transactivation domain superactivate the chromatin unfolding. The results suggest that the chromatin unfolding assay can aid in the characterization of deleterious mutations in the C-terminal transactivation domain of BRCA1 and may provide more reliable presymptomatic risk assessment.

對這些重組質(zhì)粒的染色質(zhì)伸展活性檢測表明毛片网址站，野生型pwt和兩種良性多態(tài)性突變體不具有染色質(zhì)伸展活性或只有極微弱的染色質(zhì)伸展活性www干干干操操操，而其他4種乳腺癌易感突變體均具有過強(qiáng)的染色質(zhì)伸展活性，提示利用染色質(zhì)伸展技術(shù)可預(yù)測BRCA1轉(zhuǎn)錄激活區(qū)基因型與乳腺癌發(fā)生風(fēng)險的表現(xiàn)型的關(guān)系国产一区二区免费A片。

The results of its intrinsic fluorescence spectroscopy and fluorescence phase diagram showed that when the guanidine hydrochloride concentration in denaturation solution was about 1.0 mol/L, there existed a partially folded intermediate of Bacillus amyloliquefaciens a-amylase during its unfolding procedure, which followed a three-state model; the result of its fluorescence probe showed that when the guanidine hydrochloride concentration in denaturation solution was about 1.0 mol/L, there existed some stable hydrophobic regions, which could interact with a hydrophobic reagent 8-anilino-1-naphthalene sulfonic acid, in the partially folded intermediate of Bacillus amyloliquefaciens a-amylase; and the results of fluorescence quenching using acrylamide and potassium iodide as quenchers showed the distribution of Trp residues in Bacillus amyloliquefaciens a-amylase in different denaturation solution, with the maximum number (8) of tryptophan residues in a partially folded intermediate Bacillus amyloliquefaciens a-amylase molecule could be quenched by potassium iodide; and the results of their protein electrophoresis and SEC showed that no aggregate or aggregate precipitation of Bacillus amyloliquefaciens a-amylase formed during the whole unfolding procedure of Bacillus amyloliquefaciens a-amylase induced by guanidine hydrochloride.

內(nèi)源熒光光譜和熒光相圖結(jié)果表明人人摸人人操人人判人人干人人，當(dāng)變性液中鹽酸胍濃度約為1.0 mol/L時，芽孢桿菌a-淀粉酶的去折疊過程中出現(xiàn)一個部分折疊中間體www.操逼。com，其去折疊過程符合&三態(tài)模型&天天日曰；熒光探針結(jié)果表明韩国A级毛片免费久久，在溶液中鹽酸胍濃度約為1.0 mol/L時，中間態(tài)芽孢桿菌a-淀粉酶分子中存在著能夠與探針分子1-苯胺基-8-萘磺酸結(jié)合的穩(wěn)定的疏水區(qū)域摸一摸AV；熒光猝滅研究給出了不同程度變性的淀粉液化芽孢桿菌a-淀粉酶中的Trp的分布情況欧美乱操屄片，結(jié)果表明中間態(tài)芽孢桿菌a-淀粉酶分子中能夠被碘化鉀猝滅的位于分子表面的色氨酸殘基數(shù)目達(dá)到最大的8個；蛋白電泳和體積排阻色譜結(jié)果表明免费裸体黄网站，在鹽酸胍誘導(dǎo)的芽孢桿菌a-淀粉酶分子的整個去折疊過程中国产福利一区二区精品免费，不會以共價鍵或非共價鍵形式形成芽孢桿菌a-淀粉酶分子之間的集聚體或集聚體沉淀。