Several anti-tumor cell lines and carbonic anhydrase Ⅱ model were established. More than 10000 compounds and extracts from plants were screened using these models and about 10 compounds showed strong inhibitory activities. Two species of plants Inula helianthus-aquatica and Saussurea deltoidea were chosen to investigate chemical and bioactivity constituents based on the results of screening of extracts and fractions. 58 compounds were isolated and identified from these two plants, 6 compounds were found to be new and 14 compounds showed anti-tumor activities. We also studied the anti-tumor mechanism of the compound bigelovin isolated from Inula helianthus-aquatica. Bigelovin was found with apoptotic activity against cell line U266 by lowering the amount of important transcription factor E2F-1 which inhibits the cell cycle at G0/G1 stage. Docking study on 7 natural new phenolic inhibitors of CA Ⅱ and 3D-QSAR study on 61 sulfonamide inhibitors of CA Ⅱwere also investigated. The calculated results were in good correlation with experimental results.

基于以上兩種重要疾病和研究組方向亚洲五月综合，本論文工作開展了多個腫瘤細(xì)胞株和碳酸酐酶Ⅱ靶標(biāo)模型的建立和篩選工作国产自在，累計篩選1萬多個/次樣品，發(fā)現(xiàn)10余個活性較強(qiáng)化合物欧美老熟妇A片在线播放；從粗提取物篩選結(jié)果中選取兩種抗腫瘤活性強(qiáng)的菊科植物水朝陽旋覆花(Inula helianthus-aquatica)和三角葉鳳毛菊進(jìn)行了系統(tǒng)化學(xué)和活性成分研究日韩一区观看视频，分離鑒定了58個化合物，發(fā)現(xiàn)6個新化合物和14個抗腫瘤活性化合物；通過合作對水朝陽旋覆花中活性較強(qiáng)的bigelovin進(jìn)行了抗腫瘤作用機(jī)制研究黄色网址A片免费观看，發(fā)現(xiàn)它可能是通過降低G2期重要的轉(zhuǎn)錄因子E2F-1国产一区日韩欧美黑人，致使細(xì)胞周期阻滯在G0/G1期，引起多發(fā)性骨髓瘤U266細(xì)胞凋亡一级a毛片永久免费观看网站；開展了7個新的天然酚類CAⅡ抑制劑的對接研究和61個合成的系列磺酰胺類CAⅡ抑制劑的3D-QSAR分析一本到在线DVD国产日韩欧美，結(jié)果表明計算與實驗一致。

Chapter 9 is conclusion and future prospect. There are five innovative findings in the paper. Firstly, the evolvement of extensions and connotations of two reengineering styles is analyzed based on their high risk, and finding their trends of amalgamation. With this, the concept of corporation reengineering is then redefined combining core competence theory and ideas of process change management, and decompounding it into two parts: pre-reengineering and post-reengineering. Its inner relationships are analyzed and explained by economics theory. Secondly, establishing a analysis framework of reengineering risks, risk factors of foreign BPR are analyzed and concluded systematically for the first time. Reengineering risks are divided into three parts: plan, design and executive based on process and project management, then risk factors system is abstracted. Thirdly, 72 reengineering corporations in Jiangsu province are investigated on risk condition. Furthermore, risk factors in every part are analyzed and reduced experimentally by factor analysis method, and a risk factors system to suit Chinese corporation's reengineering is established. Fourthly, setting up a choice model of reengineering projects, the objective optimization model is presented to ascertain the weigh of each factor, a method of sequencing reengineering projects is presented so that risk of each reengineering project can be evaluated and compared effectively. Fifthly, an integration relationship model among IT, BPR and strategy is established aiming at productivity paradox derivative from IT and its dual effects on BPR, IT investment priorities in BPR is narrated deeply.

本論文的創(chuàng)新點體現(xiàn)在五個方面：1）基于上述兩種重組方式的高風(fēng)險性久久久久国产99久久国产，對它們的外延和內(nèi)涵演變進(jìn)行了分析日本xx，發(fā)現(xiàn)它們?nèi)找嫒诤系内厔荩蝗缓蠼Y(jié)合核心能力理論和流程變革管理的思想對企業(yè)重組的概念進(jìn)行了界定亚洲国产福利精品网站，將其分為&前重組&和&后重組&兩部分3A级黄片，并對其內(nèi)部關(guān)系進(jìn)行了詳細(xì)分析，同時應(yīng)用經(jīng)濟(jì)學(xué)理論對其進(jìn)行了解釋无吗黄片免费视频。2）建立了重組風(fēng)險的分析框架正在播放国产一级特黄，并首次較為全面地分析和歸納了國外企業(yè)重組的風(fēng)險因素，根據(jù)重組的過程和步驟以及項目管理的觀點第一页国产屁屁影院，將重組風(fēng)險劃分為計劃人人澡人人看人人添百度、設(shè)計和執(zhí)行3個部分，并在此基礎(chǔ)上提煉出企業(yè)重組的風(fēng)險指標(biāo)體系AAAAA黄片免费观看。3）運(yùn)用現(xiàn)場訪談、問卷調(diào)查的方法欧美乱伦网站，調(diào)查了江蘇省72家企業(yè)重組的風(fēng)險情況我要看中国黄色网站黄a片，然后利用因子分析法對每一部分的每一風(fēng)險因素進(jìn)行實證分析，對風(fēng)險指標(biāo)進(jìn)行了約減附近人搜的毛片网站，建立了比較完善的適合我國企業(yè)的重組風(fēng)險指標(biāo)體系久久A级免费播放。4）建立了重組變革方案的選擇模型，然后針對不同的重組方案提出了確定指標(biāo)權(quán)重的目標(biāo)優(yōu)化模型免费看一级黄色视频，并基于三角模糊數(shù)之間兩兩比較的可能度概念国内自拍日韩免费观看，提出了一種重組方案排序法，從而可以有效地對各種變革方案的風(fēng)險進(jìn)行評估和比較欧美性高潮视频。5）針對信息技術(shù)所造成的&生產(chǎn)率悖論&現(xiàn)象及其對重組的雙重影響中文一日韩一视频一国产，建立了信息技術(shù)、企業(yè)重組和企業(yè)戰(zhàn)略之間的整合關(guān)系模型2020国内揄拍国内精品，并對重組中信息技術(shù)投資的優(yōu)先權(quán)問題進(jìn)行了深入的闡述www久草。

Secondly, the paper has carried on the analysis to the millimeter wave blasting fuse near field target characteristic, and has produced a RCS measuring technique. The analysis is that non- atmosphere window triangle wave modulation millimeter wave blasting fuse slip frequency spectrum, which has completed under the triangle wave modulation slip frequency signal time domain and the frequency range analysis.

隨后對毫米波引信近場目標(biāo)特性進(jìn)行了分析，并給出了一種RCS的測量方法欧美日韩在线视频黄色，并系統(tǒng)分析了非大氣窗口三角波調(diào)制毫米波引信的差頻頻譜免费一级在线，完成了三角波調(diào)制下的差頻信號時域和頻域分析。

Firstly, the incommensurate magnetic scattering of the doped single-layer triangular lattice in the normal state has been studied. It is shown that away from half-filling the commensurate peak is replaced by six incommensurate peaks located at [ (1-δ〓), ] , [ (1-δ′〓), ] , [ (1-δ"〓), ] , respectively, and 〓〓. The incommensurability parameter δ increases with doping at lower doping concentration, while saturates at higher dopings. These peaks broaden and weaken in amplitude with increasing energy and temperature, with the positions of the incommensurate peaks not changing with the energy.

利用t-J模型，討論了單層和雙層三角晶格材料的非公度磁散射人成国产免费网站，結(jié)果表明：隨著摻雜的增加欧美二区在线视频，三角晶格反鐵磁體出現(xiàn)公度-非公度轉(zhuǎn)變，即由一個公度峰變?yōu)榱鶄€非公度峰6080午夜福利毛片，并且非公度率在較低摻雜時隨著摻雜濃度的增大而增大18岁以下禁看的黄色网站，在較高摻雜濃度時將達(dá)到飽和；雖然非公度峰的權(quán)重隨著能量的增大而減小456小视频，但非公度峰的位置與能量無關(guān)69免费视频，即非公度率是不隨能量變化的，并且我們還發(fā)現(xiàn)非公度峰的權(quán)重隨著溫度的升高也是減小的日韩手机福利写真在线观看。

Triangle valve with internal thread pipe thread and external thread of two, to choose according to need; have to pay attention to is currently on the market, some triangular zinc alloy valves, the valve price is lower than the average product, but was easy to fracture caused by corrosion.

三角閥的管螺紋有內(nèi)螺紋和外螺紋兩種日本三级欧美三级人妇视频，要根據(jù)需要選購；還要注重的是目前市場上有部分鋅合金制造的三角閥污污色色，該閥門售價比一般產(chǎn)品要低视色4se，但易腐蝕而造成斷裂。

Traditionally, the taxonomic basis of planarians is based on the anatimic characteristic of their reproductive system.

日本三角渦蟲是國際上研究渦蟲再生和發(fā)育的模式動物色影音，三角渦蟲傳統(tǒng)的分類學(xué)基礎(chǔ)是以其生殖解剖學(xué)特征為依據(jù)5566综合网。

Structure form adopts converse triangle beam double-hole connection welded by general electric trolley wall plate and steel plate, connection shaft, triangle beam bottom is connected with girder by nut and thrust bearing, triangle beam could rotate 360 degrees horizontally, thus realize whole set electric trolley horizontal rotation, largely reduce curve track curvature radius of electric hoist traveling mechanism.

結(jié)構(gòu)形式采取通用電動小車墻板與一個鋼板和連接軸組焊的倒三角形吊梁雙孔連接，三角吊梁下面通過螺母及推力軸承與一個橫梁連接国产在线.c，三角吊梁相對橫梁可在水平方向做360度旋轉(zhuǎn)国产精品不卡一区，從而實現(xiàn)電動小車的整體水平方向轉(zhuǎn)動，大大減小了電動葫蘆運(yùn)行機(jī)構(gòu)弧形軌道曲率半徑亚洲色呦呦在线。

This paper mainly analyses dispersion frequency signals time and frequency property of triangle wave modulation. Real 5mm dispersion frequency signal is collected. The theory data and real data are compared and analyzed. It shows 5mm radar forepart is practicable, it also supplies theory base to design back signal processing circuit.

主要完成了三角波調(diào)頻體制下的差頻信號在時域和頻域兩方面的特性分析美女视频色网站国产，并采集了5mm波段實際的三角波調(diào)制差頻波形，通過將理論值與實測值的比較分析色污网站免费在线观看，表明5mm樣機(jī)前端部分的可靠性特级婬片欧美国语高清视频一，為后面的信號處理電路設(shè)計作準(zhǔn)備。

Bius digital base band communication system of five often used modem function set, those are the even and odd symmetrical triangle wave, even and odd symmetrical square wave and saw-tooth wave and their inverse transforms, are simulated 10000 times, and the fluctuation ranges of the error rate P(subscript b are observed.

bius數(shù)字基帶通信系統(tǒng)中偶對稱三角波国产在线精品永久网址、奇對稱三角波五月婷婷久久久、偶對稱方波、奇對稱方波和鋸齒波這5種常用的調(diào)制解調(diào)函數(shù)族及其逆變換進(jìn)行仿真1萬次又色又污视频网站，觀察錯誤概率P

During the TIN generating, it puts emphasis on analysis and treatment discrete data using Delaunay triangular net.

在不規(guī)則三角網(wǎng)TIN的生成中YouJizz丰满熟妇短视频，重點采用Delaunay三角網(wǎng)分析和處理離散點的數(shù)據(jù)。