The immunoregulation activity of SPG-1 mainly existed in the part of sugar chain, but keeping its molecular structure intact had some effects on its immunoregulation activity; SPG sulphation had reducing effects on the immunoregulation of SPG-1, whereas, after medium and low acetification of SPG, the immunoregulation of SPG was enhanced. Conversely after high acetification, the immunoregulation of SPG-1 decreased, that is, after introducing sulfuric and acetic acid base in SPG-1, its immunoregulation changed. All of these indicated the structure of SPG-1 was closely connected with its immune activity.⑤.

甘薯糖蛋白SPG-1的免疫調(diào)節(jié)活性主要在其糖鏈部分五月天人人干人人干，但保持分子結(jié)構(gòu)的完整性對其免疫調(diào)節(jié)的活性有一定的作用大屁股91精品；甘薯糖蛋白硫酸化對甘薯糖蛋白SPG-1的免疫調(diào)節(jié)有降低作用国产日韩视频合集一区，而中亚洲精品无码福利在线观看、低度乙酰化后国产福利最新地址发布页8010，可提高甘薯糖蛋白的免疫調(diào)節(jié)作用欧美日大黄片，高度乙酰化后則降低其免疫調(diào)節(jié)作用，即甘薯糖蛋白引入乙酰基和硫酸基團(tuán)后A片视频观看，其免疫調(diào)節(jié)活性發(fā)生了改變国产一级视频在线观看免费，這些均表明了甘薯糖蛋白的結(jié)構(gòu)與其免疫調(diào)節(jié)活性有密切的關(guān)系。

We investigated constituent of triterpenoid saponins ofAlbizzia, two new compounds together with two known compounds were isolated from Albizzia julibrissin Durazz. by using column chromatography (macroreticular resin, silica gel, Sephadex gel, reverse phase silica gel),preparative HPLC methods et al.On the basis of spectroscopic analysis, including IR,ESI-MS,~1H-NMR,~(13)C-NMR,HMBC,HMQC,~1H-~1HCOSY and chemical methods, the structure of two new compounds were identified as 3 - O -[β-D-xylopyranosyl(1→2)-β-D-fucopyranosyl (1→6)-β- D -2- deoxy - 2 - acetoamidoglucopyranosyl] -21-O-[(6S)-2- trans- 2,6-dimethyl - 6 - O-β- D - quinovopyranosyl -2,7- octadienoyl] - acacic acid- 28 - O-β-D-glucopyranosyl(1→3)[α-L-arabinofuranosyl(1→4)]-α-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside acacic acid 3- O -β- D- glucopyranosy(1→3)-β- D- fucopyranosl(1→6) [β-D- xylopyranosyl (1→2)]-β-D-glucopyranoside ;two known compounds were acacic acid lactone 3- O -β-D- xylopyranosyl-(1→2)-β-D-fucopyranosl (1→6)- 2-deoxy -2 -acetoamido -β-D- glucopyranoside ; acacic acid lactone 3- O-β-D-xylopyranosyl(1→2)-α-L- arabinopyranosl (1→6)- 2- deoxy - 2- acetoamido -β-D-glucopyranoside . The study lays chemical foundation and chemical reference substance for enhancing quality standard of Albizzia julibrissin Durazz.

本研究論文在綜述國內(nèi)外對合歡屬Albizzia三萜皂苷化學(xué)成分和藥理作用研究進(jìn)展的基礎(chǔ)上国产免费特大黄色网站，利用傳統(tǒng)植化分離手段和現(xiàn)代分離技術(shù)亚洲天堂在线网站，包括大孔樹脂、硅膠欧美一级A片裸体做受在线、葡聚糖凝膠亚洲欧美另类激情综合区183、反相硅膠等柱色譜，制備高效液相色譜法等技術(shù)從中藥合歡皮中分離得到了4個化合物欧美性爱zozozoxxxx，其中国产精品黄黄久久久免费看视频，2個新化合物和2個己知化合物，并進(jìn)一步通過現(xiàn)代分析技術(shù)IRA片网站在线免费观看，ESI-MS免费看看黄色片，~1H-NMR，~(13C-NMR色哟哟WWW网址，HMBC超碰免费公开人妻人人，HMQC，~1H-~1HCOSY等和化學(xué)方法鑒定了2個新化合物的結(jié)構(gòu)分別是：3-O-[β-D-吡喃木糖基(1→2)-β-D-吡喃夫糖基(1→6)-β-D-2-去氧-2-乙酰氨基吡喃葡萄糖基]-21-O-[(6S)-2-反式-2一级毛片一级毛片AAAA级，6-二甲基-6-O-β-D-吡喃雞納糖基-2一级免费视频国产，7-辛二烯酸基]-金合歡酸-28-O-α-L-呋喃阿拉伯糖基(1→4)[β-D-吡喃葡萄糖基(1→3)]-α-L-吡喃鼠李糖基(1→2)-β-D-吡喃葡萄糖苷，金合歡酸3-O-β-D-吡喃葡萄糖基(1→3)-β-D-吡喃夫糖基(1→6)[β-D-吡喃木糖基(1→2)]-β-D-吡喃葡萄糖苷操美女视频在线网站；2個已知化合物結(jié)構(gòu)分別是：金和歡酸內(nèi)酯3-O-β-D-吡喃木糖基(1→2)-β-D-吡喃夫糖基(1→6)-β-D-2-去氧-2-乙酰氨基吡喃葡萄糖苷天堂干屄免费视频，金和歡酸內(nèi)酯3-O-β-D-吡喃木糖基(1→2)-α-L-吡喃阿拉伯糖基(1→6)-β-D-2-去氧-2-乙酰氨基吡喃葡萄糖苷综合激情区小说区图片区。

The reaction of calcium L-threonate with hydrogen bromide in acetic acid readily yields (2S, 3S)-2, 4 -dibromo-3 -hydroxy butanoic acid which was further converted into methyl (2s, 3S)-2,4-dibromo-3-hydroxybutanoate by treatment of methanol.

在化合物12上引入氨基甲酰基可用二氯磷異氰酸酯国产综合一区二区三区精品、氯乙酰異氰酸酯或氯磺酰異氰酸酯日本片一级，隨之引入的二氯磷酰基最新国产裸模视频视频在线、氯乙酰基或氯磺踝耘耐蹬牡谄咭常基可分別用碳酸氫鈉、N-甲基二硫代氨基甲鈉或亞硫酸鈉脫去日本一本亚洲免费区。

A series of p-toluene sulfonylamido acetacylhydrazone derivatives were synthesized from p-toluenesulfonyl chloride which reacted with glycine to get the intermediate p-toluene sulfonylamido glycine, then through the esterification, hydrazinolysis to afford another intermediate p-toluene sulfonylamido acethydrazide, which condensed with different aldehydes to obtain the target compounds that were characterized by IR, 1H NMR, 13C NMR spectra and elemental analysis.

魏太保 ；冷艷麗浮力国产在线；王永成人人摸人人澡人人；張建輝；張有明*摘要：以對甲苯磺酰氯為原料97免费人妻视在线视频，通過與氨基乙酸反應(yīng)得到中間體對甲苯磺酰氨基乙酸九九成色视频在线观看，再經(jīng)酯化、肼解得到對甲苯磺酰氨基乙酰肼狼友首页，然后與相應(yīng)的醛縮合得一系列對甲苯磺酰胺基乙酰腙類化合物黄页视频免费在线看。其結(jié)構(gòu)經(jīng)元素分析， IR91人妻论坛兴趣杂谈， 1H NMR和13C NMR確證亚洲小说图片综合在线专区。

Firstly, 3-ethylthiobutanal was prepared from crotonaldehyde reacting with ethanehiol in triethylamine with high yield. Secondly, methyl acetoacetate was converted to 6-ethylthiohept-3-en-2-one by three steps via hydrolysis, condensation with 3-ethyltio-butanal and dehydration, then 6-ethylthiohept-3-en-2-one was cycloco ndensed with dimethyl malonate by Michael addition and Claisen condensation, followed by saponification and decarboxylation to give the intermediate of 5-(2-ethylthiopropyl)-cyclohexane-1,3-dione.

首先，以巴豆醛與乙硫醇為原料日韩高清在线精品观看网站免费，在三乙胺的催化作用下高收率制得3-乙硫基丁醛日韩网友自拍区在线观看网站；然后從乙酰乙酸甲酯出發(fā)，通過堿水解97人人看碰人免费公开视频观看、與3-乙硫基丁醛縮合无码在线观看毛片、脫水三步反應(yīng)合成6-乙硫基-3-烯-2-庚酮，接著6-乙硫基-3-烯-2-庚酮與丙二酸二甲酯通過Michael加成和Claisen縮合成環(huán)夜操三级片，再通過皂化和脫羧反應(yīng)生成中間體5-[2-丙基]-1黄色视频人人干人，3-環(huán)己二酮；再與丙酸酐反應(yīng)丙跻槐揪镁米酆现形淖帜唬化欧美噪B视频69，最后與0-3-氯-2-丙烯基羥胺肟化，得到目標(biāo)化合物烯草酮欧美老人激情综合网欧美综合激情。

A process for preparingp-fluo-2-(2-methyl-3-propionyl)-4-oxy-N,3-diphenyl-phenylbutylamide includes such steps as Friedle-Craft acylating of newly prepared phenylacetyl chloride and fluorobenzene under catalysis of AlCl3 to obtain 4-fluoro-phenylbenzyl ketone, brominating at carbonyl alpha position under catalysis of less AlCl3 to obtain alpha-bromo-4-fluo-phenylbenzyl ketone, and condensing with isobutyryl acetanilide under action of sodium ethoxide.

本發(fā)明涉及一種制備對氟－2－(2－甲基－3－氧丙基)－4－氧－N亚洲色婷婷开心综合，3－二苯基－苯丁酰胺(1)的方法，其包括以下步驟：新制的苯乙酰氯與氟苯在AlCl3催化下進(jìn)行Friedle－Craft?1国内精天天；磻?yīng)免费看黄网站9，得到對4－氟－苯基芐基酮(4)国产精品国产三级农村A∨；化合物(4)在少量AlCl3催化下進(jìn)行羰基α位溴化，得到α－溴－4－氟－苯基芐基酮(5)超碰人人做人人操人人爽；然后(3)異丁酰乙酰苯胺在乙醇鈉作用下與化合物(5)進(jìn)行縮合黄色视频一级链接。

Determining the dilution enthalpies of DMF and DMA in aqueous glycerol solutions of various molalities, we discussed peptide bond and hydrophobic side chains interacting with glycerol in aqueous solutions. Molecular dynamics simulating ethylene glycol and glycerol solutions have been done to study the microscopic structure of polyhydroxy compounds solutions.

本文用滴定量熱法研究了298.15K下酰胺(N—甲基甲酰胺、Nheyzo一区，N—二甲基甲酰胺95av视频、N—甲基乙酰胺和N，N—二甲基乙酰胺)分別在于MAO水溶液和尿素水溶液中的焓相互作用欧美一级理伦片，探討了溶劑變化對酰胺側(cè)鏈相互作用的影響激情小说亚洲色图，從肽鍵及疏水側(cè)鏈角度研究了TMAO和尿素對蛋白質(zhì)穩(wěn)定性的影響。

As a key step of the synthesis, the Friedel-crafts acylation was researched. And the optimal operation variables were determined through orthogonal experiment: when 0.lmol acetanilide, 0.26mol aluminum chloride, 0.12mol propionyl chloride and 200ml carbon disulfide are introduced, and the reaction time is 5 hour, the yield can be up to 57.3%. The solid super acid catalyst was preliminary studied. Four solid super acid catalysts were prepared to take the place of aluminum chloride, and it was indicated that AlCl3 acidic resin can better catalyze the Friedel-Crafts reaction of acetanilide.

對合成路線中的Friedel-Crafts趸破琣v免费；磻?yīng)進(jìn)行了研究草草A片，運(yùn)用正交實(shí)驗(yàn)設(shè)計(jì)確定了最佳工藝條件：當(dāng)乙酰苯胺用量為0.1mol時(shí)，AlCl_3用量為0.26moljiZZjiZZjiZZ中国人、丙酰氯用量為0.12mol亚洲日韩欧美国产V、溶劑用量為200ml、反應(yīng)時(shí)間為5h性爱日韩，產(chǎn)率可達(dá)到57.3％女高中高潮娇喘抽搐喷水视频；對于固體超強(qiáng)酸催化劑進(jìn)行了初步研究，合成了四種催化劑国产黄色A片免费看，其中負(fù)載AlCl_3強(qiáng)酸性樹脂對于乙酰苯胺的Friedel-Crafts跖访廊蘸扇似谙吖劭矗基化具有一定的催化活性。

Methods 4-Hydroxy- benzonitrile was treated with sodium hydrogen sulfide and anhydrous magnesium chloride in dimethyl formamide to give thioamide, which was then directly cyclized with ethyl 2-chloroacetoacetate without separation to give ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(2) in one-pot; then 2 was formylated with Duff reaction adopting hexamethylenetetramine in trifluoroacetic acid to give ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(3); finally, the target compound was obtained by the treatment of 3 with hydroxylamine hydrochloride and sodium formate in formic acid.

采用&一勺燴&方法女人操女人，以4-羥基苯甲腈為起始原料91资源总站，首先與硫氫化鈉和無水氯化鎂在N，N-二甲基甲酰胺中反應(yīng)国产一级黄色视频免费看，所得中間體不經(jīng)分離欧洲免费黄色网站，直接加入2-氯乙酰乙酸乙酯進(jìn)行環(huán)合反應(yīng)，得到2-(4-羥基)苯基-4-甲基-5-噻唑甲酸乙酯（2）欧洲精品色在线；然后通過六亞甲基四胺/三氟乙酸進(jìn)行Duff反應(yīng)色色无码视频，得到2-(3-甲酰基-4-羥基)苯基-4-甲基-5-噻唑甲酸乙酯（3）高清日韩精品第一页在线观看网站；再經(jīng)鹽酸羥胺/甲酸/甲酸鈉體系脫水得到目標(biāo)化合物超碰在线看。

Piperidinecarboxylic acid is used as the raw material and acetic acid as the acylating agent, followed by the addition of some acetic anhydride in the later stage to get an important organic intermediate n-acetylpiperidine-4 carboxylic acid in the yield of 92%. Toluene is used as the solvent instead of sulfinyl chloride in the acyl chlorination to produce n-acetylpiperidine-4-carbonyl chloride with the yield of 97%.

以4-哌啶甲酸為原料、醋酸為跎钜乖谙吖劭赐罚化劑每日毛片视频，后期加入少量醋酸酐反應(yīng)得到中間體N-乙酰基哌啶－4-甲酸，收率92%；在甲苯溶劑中進(jìn)行酰氯化得目標(biāo)產(chǎn)物N-乙酰基哌啶－4-甲酰氯WWWjiujiZZC0m，收率97%亚洲黄色免费网站。