Several anti-tumor cell lines and carbonic anhydrase Ⅱ model were established. More than 10000 compounds and extracts from plants were screened using these models and about 10 compounds showed strong inhibitory activities. Two species of plants Inula helianthus-aquatica and Saussurea deltoidea were chosen to investigate chemical and bioactivity constituents based on the results of screening of extracts and fractions. 58 compounds were isolated and identified from these two plants, 6 compounds were found to be new and 14 compounds showed anti-tumor activities. We also studied the anti-tumor mechanism of the compound bigelovin isolated from Inula helianthus-aquatica. Bigelovin was found with apoptotic activity against cell line U266 by lowering the amount of important transcription factor E2F-1 which inhibits the cell cycle at G0/G1 stage. Docking study on 7 natural new phenolic inhibitors of CA Ⅱ and 3D-QSAR study on 61 sulfonamide inhibitors of CA Ⅱwere also investigated. The calculated results were in good correlation with experimental results.

基于以上兩種重要疾病和研究組方向欧美日韩视频在线观看，本論文工作開(kāi)展了多個(gè)腫瘤細(xì)胞株和碳酸酐酶Ⅱ靶標(biāo)模型的建立和篩選工作另类视频一区二区三区，累計(jì)篩選1萬(wàn)多個(gè)/次樣品，發(fā)現(xiàn)10余個(gè)活性較強(qiáng)化合物无遮挡奶头污免费网站；從粗提取物篩選結(jié)果中選取兩種抗腫瘤活性強(qiáng)的菊科植物水朝陽(yáng)旋覆花(Inula helianthus-aquatica)和三角葉鳳毛菊進(jìn)行了系統(tǒng)化學(xué)和活性成分研究欧美精品黑人性XXXXWWW，分離鑒定了58個(gè)化合物，發(fā)現(xiàn)6個(gè)新化合物和14個(gè)抗腫瘤活性化合物人操在线视频97；通過(guò)合作對(duì)水朝陽(yáng)旋覆花中活性較強(qiáng)的bigelovin進(jìn)行了抗腫瘤作用機(jī)制研究性爱一级，發(fā)現(xiàn)它可能是通過(guò)降低G2期重要的轉(zhuǎn)錄因子E2F-1欧美视频在线观看熟，致使細(xì)胞周期阻滯在G0/G1期，引起多發(fā)性骨髓瘤U266細(xì)胞凋亡中文字幕黃色av；開(kāi)展了7個(gè)新的天然酚類CAⅡ抑制劑的對(duì)接研究和61個(gè)合成的系列磺酰胺類CAⅡ抑制劑的3D-QSAR分析国产一级精品A级毛片，結(jié)果表明計(jì)算與實(shí)驗(yàn)一致。

It starts transmitting information by integrating with lagen and stromatin by irritating osteocytes and chondrocytes to form rapidly extracellular matrix so as to promote repair of bone and cartilage injury.

轉(zhuǎn)化生長(zhǎng)因子β通過(guò)刺激骨久久99视频首页、軟骨細(xì)胞合成膠原和基質(zhì)蛋白欧美专区91第三页，快速形成細(xì)胞外基質(zhì)，達(dá)到其促進(jìn)骨95网站在线观看、軟骨損傷修復(fù)的作用国产在线91精品免费。

Annual average temperature and average temperature in January mainly affected accumulation of oleic and linoleic.

年平均氣溫和1月平均氣溫是影響油酸和亞油酸合成的主要因子。

Average annual relative humidity and annual average temperature mainly affected accumulation of linolenic.

年平均相對(duì)濕度和年平均氣溫是影響核桃亞麻酸合成的主要生態(tài)因子人操人人操人人超碰。

Thyroid hormone responsive spot 14, expressed in lipogenic tissues, is suggested as a transcription factor to regulate gene expression of rate-limiting enzymes in lipogenesis. Two THRSP isoforms, THRSPα and THRSP β, were detected at cDNA levels in chickens and ducks.

甲狀腺激素應(yīng)答Spot 14 (Thyroid hormone responsive spot14精品自拍视频手机在线观看， THRSP)是一個(gè)參與多種脂肪合成限速酶基因表達(dá)的轉(zhuǎn)錄調(diào)控因子，在動(dòng)物肝臟看免费5XXAAA毛片om、乳腺和脂肪組織中高度表達(dá)天堂精品视频在线综合网。

There are four kind of isoforms of endothelin in human and other mammals named ET-1, ET-2, ET-3 and ET-β, which are slightly different in construction and pharmacological effect. In human beings, ET-1 is the dominative subtypes. ET-1 remains in blood at a low level about 5ng per liter on physical state. It is synthesized, stored, released and metabolized locally. The half-life of ET-1 is about 1 hour. ET-1 is the most potent vasoconstrictive factor till now, and it is more functional in vein than in artery. In vascular bed, there are two kind of ET receptors. Type A mainly located in smooth muscle cells, whereas type B in endothelial cells. The latter can stimulate intimal hyperplasia via a parasecretion way and activate some oncogenes such as c-fos and c-myc and then enhance their expression. These alterations result in constriction of blood vessels, thus the SMC steps into proliferate state from silent state.

人及哺乳動(dòng)物體內(nèi)有四種結(jié)構(gòu)及藥理學(xué)性質(zhì)略有差異的異物體，分別為ET-1玖色视频在线、ET-2日韩精品电影在线观看播放免费、ET-3、ET-β欧美巨吊，而在人主要是ET-157pao国产成视频一永久免费，在生理?xiàng)l件下，ET-1在血漿中含量較低啪啪啪黄片视频海外版，約為5ng〓大黑吊日逼视频，故ET-1不是一個(gè)循環(huán)激素，而是局部合成釋放午夜福利小视频在线观看，局部起作用的活性物質(zhì)日韩精品网站日韩在线播放视频免费，半衰期約1小時(shí)，ET-1是目前已知的最強(qiáng)的血管收縮劑婷婷五月丁香六月综合，對(duì)靜脈的作用比動(dòng)脈強(qiáng)日韩一级婬片A片免费手机版，在血管床，ET受體有A黄片地址免费、B兩型亚洲,欧美,中文,日韩,视频骚虎视频，A型主要分布在平滑肌細(xì)胞，B型主要分布在內(nèi)皮細(xì)胞国产精品呦交在线观看，它可以通過(guò)旁分泌途徑刺激內(nèi)膜增生色色视频网址，具有有絲分裂原效應(yīng)，可以激活某些癌基因如C-fos欧美操综合、C-myc使其表達(dá)增強(qiáng)引起血管收縮男女免视频，使靜止期SMC進(jìn)入增殖期18禁黄色在线网站，還可以通過(guò)信號(hào)傳導(dǎo)途徑，與bFGF1024手机视频观看在线、GTF-β九色绿帽人妻论坛、PDGF等生長(zhǎng)因子協(xié)同作用，起共有絲分裂原作用欧美在线网站。

The first, selecting Mannitol of polyhydric and Dextran ofpolysaccharide as subsidiary material, In accordance with differentusing quantities, making up eight recipes, freeze-drying test is madewith eight recipes differently. By adjusting recipe, to select themethod of two factors three levels. The best recipe determined is thatof Mannitol(160mg/bottle) and Dextran(40mg/bottle), Solving theproblem of description日本免费一级夜夜爽V、moisture(≤1.5%)、solution(≤6s)黄色精品美女、stability(95.0～110.0%) etc., The quality of preparation has beenimproved.

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To observe the effect of diterpenoid compound 5F from Pteris semipinnata L.(5F) on the cell proliferation, collagen synthesis and the expression of connective tissues growth factor in human pterygium fibroblasts cultured in vitro.

觀察半邊旗二萜類化合物5F(5F)對(duì)體外培養(yǎng)的人翼狀胬肉成纖維細(xì)胞增殖和膠原合成及結(jié)締組織生長(zhǎng)因子表達(dá)的影響。

A gelator (G2) synthesized from 1,2,4,5-benzene tetracarboxylic acid and 4-hydroxy pyridine at molar ratio of 1:4 was characterized by 1H-NMR and FT-IR.

采用1H-NMR和FT-IR表征了在摩爾比1：4條件下就是操就是干，由均苯四甲酸和對(duì)羥基吡啶合成的一種凝膠因子(G2)人人操人人看人人插人人干。

The mechanism may be it can interference the thermotaxic center, descend the level of plasma cellular factor TNF - one of the endogenous pyrogens, inhibit the synthesis and release of central febril media PGE〓 and cAMP.

其機(jī)理可能與直接干擾體溫調(diào)節(jié)中樞作用，降低血漿中作為內(nèi)生致熱原之一的細(xì)胞因子TNF水平国产各种盗摄视频，抑制中樞發(fā)熱介質(zhì)PGE〓一级一级女人18毛片、cAMP的合成釋放等有關(guān)。