The rationals of anti-angiogenesis are the following: the therapeutic target is tumor endothelial cells which are more genetically stable, more homogeneous, and with lower mutation rate; the anti-angiogenesis drugs can contact endothelial cells directly, with higher potency and lower drug barriers and side effects; the aim of anti-angiogenesis therapy is to block the oxygen and nutrition supply from vessels, instead of killing tumor r ells per se; the aim of anti-angiogenesis is to reduce tumor size instead of eradicate tumor which are different from traditional chemotherapy.

使用抗血管新生療法根據(jù)的理論基礎(chǔ)為以腫瘤血管的內(nèi)皮細(xì)胞為治療藥物的攻擊標(biāo)的；腫瘤血管的內(nèi)皮細(xì)胞基因比較穩(wěn)定美国黄色视频免费观看、同質(zhì)性高精品黄色福利x、而且突變率低；投與的藥物可以直接接觸內(nèi)皮細(xì)胞99久久精品无码专区，減少投與藥物屏障查询黄色网站，因此增加有效投與藥物的能力及減少藥物副作用；以截?cái)喙?yīng)腫瘤氧氣養(yǎng)分的血管為目標(biāo)：以減小腫瘤的體積大小為目的国内外黄片二级，與傳統(tǒng)化學(xué)療法以根除腫瘤的目標(biāo)不同黄色免费网站在线观看。

Researches on proteid reveal that VSV N gene encoding nuclear protein is a polypeptide which is made up of 422 amino acid and has a strong hydrophility. Comparing its homogeneity with that of VSV wild strains, it shows that the nuclear protein is highly conservative due to the high homogeneity of sequences which is above 98. 8%. It provides a basis for establishing clinical VSV diagnostic method.

蛋白質(zhì)分析發(fā)現(xiàn)，VSV N基因編碼的核蛋白是由422個(gè)氨基酸組成的多肽亚洲日韩毛片一级无码，具有較強(qiáng)的親水性欧美精品在线看，同VSV野生型病毒株的核蛋白同源性比較，其氨基酸序列的同源性高達(dá)98.8%以上日韩午夜软件在线观看视频网站大全，證明VSV核蛋白具有很好的保守性18岁一下禁止观看网站，為臨床上建立VSV診斷方法奠定了基礎(chǔ)。

We also observed that the genomic regions with higher GC content tend to form nucleosome with greater stability.

我們?cè)诰€蟲核小體DNA中觀察到的175-nt周期信號(hào)與在陰道滴蟲基因序列中觀察到的120.9-nt周期信號(hào)為同一類信號(hào)日韩午夜福利片免费观看一区，反應(yīng)的都是纏繞在核小體上的DNA與位于核小體之間的DNA在核苷酸組成上的不同进网站看黃色A片。