To choose SD rat as experiment obiect, which was divided in to 5 groups: normal control group, model group, methylaminopterin-treat group, tripterygiumglycosides-treat group, and GuiZhiShaoYaoZhiMuTang-treat group, establishing immunityinflammation rat model., through measuring rat voix pedis intumesce degree, the content ofIL-6, TNF-A in peripheral blood, and rats weight as well as organ index, we can observe theeffect of GuiZhiShaoYaoZhiMuTang for treating adjuvant-induced arthritis rat and theby-effect.

以SD大鼠為實(shí)驗(yàn)對(duì)象，將大鼠隨機(jī)分為5組：正常對(duì)照組久久精品国产一区二区三区、模型對(duì)照組日韩一区二区精品久久、甲氨喋吟治療組、雷公藤多甙治療組一级大片黄、桂枝芍藥知母湯治療組手机在线AⅤ片免费视频观看。建立免疫性炎癥關(guān)節(jié)炎大鼠模型。通過測量大鼠足跖腫脹程度一级精品一区视频在线观看，外周血IL-6全免一级久久久久片、TNF-α及大鼠的體重和臟器指數(shù)，來觀察桂枝芍藥知母湯對(duì)佐劑性關(guān)節(jié)炎大鼠的治療作用和副作用欧美熟女乱交。

The comparisons of biochemistry between OP and OR rats The differences between OP and OR rats included not only body weight, but lipids metabolism and insulin sensitivity as well, characterized with insulin resistance, increasing in serum free fatty acids and ketone body, and hepatic TC and TG in OP rats. However, no significant differences were observed in serum TG, TC, LDL, HDL and fasting glucose between OP and OR rats.⑶Comparisons of metabolites in serum, urine and liver tissue between OP and OR rats①There were significant differences in amino acids concentration between OP and OR rats,especially in liver tissue, such as high concentrations in ketogenic and glucogenic amino acids in OP rats, suggesting differences in amino acids metabolism;② The different metabolites between OP and OR rats included increasing of various saturated fatty acids and decreasing of polyunsaturated fatty acids in OP rats;③The urinary metabolites analysis indicated that different structure or metabolism of gut microflora might exist between the two phenotypes, which probably influenced the regulation of body weight gain;④The end-products of catecholamines in urine and intermediates of krebs cycle in serum in OP rats were all up-regulated, suggesting that the activity of sympatheic nervous system and energy metabolism was higher in OP rats than OR rats.

胰島素耐受實(shí)驗(yàn)和胰島素敏感指數(shù)表明OP動(dòng)物的胰島素敏感性較OR動(dòng)物下降手机在线一区二区，而OP大鼠血清中游離脂肪酸、酮體最新免费黄网、肝臟總膽固醇和甘油三酯水平顯著升高；但是成年人免费看的视频大全，OP與OR大鼠血清中總膽固醇在线看日本片专区品尚网、甘油三酯、低密度脂蛋白国产黄色A片网站、高密度脂蛋白和空腹血糖等的水平并無顯著性差異欧美图片亚州图片性爱图片自拍偷拍；⑶肥胖易感與肥胖抵抗大鼠血清、尿液和肝臟組織提取物中代謝物的比較研究表明：①OP與OR大鼠的血清欧美性爱一区视频、尿液和肝組織提取物中多種氨基酸的含量存在顯著差異美国一级黄片A久久，并以肝組織中的差異氨基酸數(shù)量為最多，包括各種生酮和生糖氨基酸水平在OP組的升高另类图片一区二区三区，說明氨基酸代謝的差異是兩種體重表型大鼠之間存在的重要差異特征之一国产精品天堂Av妓女；②OP與OR動(dòng)物肝臟和血清差異代謝物中包含多種飽和長鏈脂肪酸的升高如十四烷酸、十六烷酸亚洲欧美日韩国产另类、硬脂酸等和多不飽和脂肪酸的下降如亞油酸和花生四烯酸九一在线视屏，說明兩種體重表型動(dòng)物的肝臟脂肪酸代謝存在明顯差異；③長期高脂飲食喂養(yǎng)后欧美日韩精品精品区，動(dòng)物的尿液代謝物分析表明OP與OR動(dòng)物體內(nèi)的腸道菌群結(jié)構(gòu)存在差異人人上人人操人人干，這些菌群上的差別可能在動(dòng)物體重增長的調(diào)節(jié)上產(chǎn)生影響；④與OR動(dòng)物相比毛片一区网站，OP動(dòng)物尿液代謝物中兒茶酚胺類遞質(zhì)的代謝終產(chǎn)物如高香草酸最新免费a电影网站、扁桃酸和4-羥基苯乙酸明顯升高。

Result: Maidang Rutong granule showed significant enhancement for lactescence and the offspring's body weight. It could antagonize the decrease of serum prolactin and the atrophy of mammary gland induced by l -dopa.

結(jié)果：麥當(dāng)乳通顆僚访来笃谙呙夥压劭矗可顯著增加缺乳母大鼠的泌乳量亚洲国产三级AV，可顯著對(duì)抗左旋多巴引起的母鼠血清催乳素減少，明顯對(duì)抗左旋多巴引起的大鼠乳腺萎縮，并顯著提高其所喂養(yǎng)的仔鼠體重增加率A级黄色毛片XXXXX。

It were analyzed DNA polymorphism in baby rats between outbred Wistar and SD rats with 30 microsatellites DNA loci of PCR amplification. And was breeding baby inbred rats using high and middle of Coefficient of similarity with female SD rats of F0. It was indicated that there were hybrid and polymorphism loci, there weren't homo-gene loci of F2. It were monomorphism homo-gene for 27, rate of homo-gene loci for 90%.

利用PCR擴(kuò)增30個(gè)微衛(wèi)星DNA位點(diǎn)對(duì)封閉群SD和Wistar大鼠交配繁殖的仔代鼠進(jìn)行微衛(wèi)星DNA多態(tài)性分析激情三级片网址，仔代中與母代SD大鼠相似系數(shù)高的與中的進(jìn)行定向交配繁殖。F2代大鼠均為雜合多態(tài)的位點(diǎn)久久久九九少女，沒有純合位點(diǎn)人人干,人人拍,人人吊,人人操；到F9代時(shí)基因純合位點(diǎn)達(dá)27個(gè)，純合基因位點(diǎn)率為90%A片ⅩXXXX。

The time and frequency of the polecat searching different preys and burrows were nearly the same. The polecat attacked virtually all prey offered and thus exhibited opportunistic foraging behaviour. However, it did not captured all prey with equal sequence. It first captured the zokor, then the pika and last for the root vole. In addition to using the typical musteline killing method of biting the nape of the neck, the polecat evolved a variety of killing methods suited to a range of prey types depending on the activity, size and anti-predation ability of prey. The zokor was bitten on the head, whereas the pika was killed by bites to the head or throat and the root vole was killed by bites to the head or chest. The time polecats pursued the root vole was the longest, followed by that used in pursuing the pika and the zokor.

實(shí)驗(yàn)結(jié)果表明：艾虎對(duì)三種獵物的搜尋時(shí)間和搜尋頻次基本一致亚洲欧美中文精品，在搜尋獵物的過程中并非已知洞道系統(tǒng)中所存在的食物信息，是一種機(jī)會(huì)主義的捕食者三级黄美女安全色网站；艾虎除了具有典型鼬科動(dòng)物捕殺獵物的方法外在线免费观看一区，能夠根據(jù)獵物的大小、活動(dòng)性和反捕食能力采用不同的捕殺方法毛片一区二区三区免费，在捕殺獵物的過程中首先捕殺高原鼢鼠免费看很黄A片在线观看视频，其致死部位全部為頭部，其次捕殺高原鼠兔欧洲无码高清视频在线，其致死部位除了頭部外黄色插处网站，明顯增加了頸部的比例，最后捕殺根田鼠锕锕锕锕锕锕好污网站入口，其致死部位主要是頭部和胸部在线黄色网站亚洲欧美；艾虎在捕殺獵物的過程中，追擊根田鼠的時(shí)間最多色多多性爱视频，追擊鼢鼠的時(shí)間最少淫淫爽人人操人人狠，而用于捕殺根田鼠的時(shí)間最少，用于捕殺鼢鼠的時(shí)間最多77se77亚洲欧美在线，艾虎捕殺高原鼠兔后單位時(shí)間內(nèi)獲得的能量值最大色欲性爱视频在线观看，其次為捕殺高原鼢鼠，而捕殺根田鼠后單位時(shí)間內(nèi)活動(dòng)的能量值最小黄片国产免费看。

Results:(1) FSN can inhibit secondary joints swelling and multi-arthritis evidently, improve the whole condition of rats; at the same time, it can also lighten the synovial inflammation and hyperplasia of lesion joints distinctly, and prevent the joint cartilage and bone from destruction; the collective efficiency of FSN is better than TWP.(2) FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th / Ts and Thl / Th2 cells balance in peripheral blood, restrain exorbitant TNF- a ? IL-1 produced by PM O , thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF- a mRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflamination and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue,reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage.Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

結(jié)果：(1)FSN有明顯的抗炎作用激情图片久久久，可顯著抑制AA大鼠足跖腫脹與多關(guān)節(jié)炎，改善大鼠的全身情況国产一区二区三区性交黄片，同時(shí)明顯減輕病變關(guān)節(jié)滑膜炎癥與增生蜜桃无码成人影片在线播放，防止關(guān)節(jié)軟骨及骨質(zhì)的破壞，其綜合作用優(yōu)于TWP只有美女的黄色网站；(2)FSN還能使AA大鼠低下的脾LTT恢復(fù)至接近正常真人a一级性交，糾正外周血中T細(xì)胞亞群Th／Ts及Th1／Th2平衡紊亂，抑制大鼠PHφ過高的TNF-α欧美在线观看视频免费A片、IL-1分泌日韩最新版中文无码视频下载网站，而發(fā)揮抗炎和免疫調(diào)節(jié)作用菊花奴隶人妻品评会；(3)在病變關(guān)節(jié)局部，F(xiàn)SN能顯著抑制AA大鼠滑膜細(xì)胞異常增高的TNF-αmRNA的表達(dá)欧美二级三级黄色片视频，降低滑膜組織中NF-kB表達(dá)啪啪视频免费试看，并增加凋亡蛋白酶Caspase-3表達(dá)，從而抑制滑膜的炎癥與增殖99爱国产视；(4)FSN還可下調(diào)滑膜組織中VEGF表達(dá)国产美女在线精品91，減少血管新生，由此抑制血管翳的形成及其對(duì)軟骨和軟骨下骨的侵蝕你懂得的永久；(5)FSN的上述作用皆呈現(xiàn)一定的量效依賴關(guān)系美女的隐私秘视频播放免费，高劑量組作用優(yōu)于低劑量組。

Objective To establish rat model with polycystic ovary with two different methods:testosterone plus human chorionic gonadotropin and progestogen plus HCG,compare the rat models induced by testosterone plus HCG with the patients with polycystic ovary syndrome in the aspects of ovarial morphous and gonadal hormone,and investigate whether testosterone with HCG is the effective method to establish rat model with polycystic ovary syndrome,than compare two methods(T+HCG and P+HCG)finally to draw a conclusion if there are any difference or similary between the two methods and which one is more ideal and convenient.Methods 60 SD female rats of 23 days were divided into three groups in random.

目的 本實(shí)驗(yàn)用睪酮聯(lián)合絨毛膜促性腺激素及炔諾孕酮聯(lián)合HCG兩種方法分別建立多囊卵巢大鼠模型亚欧精品在线观看，將模型鼠的卵巢形態(tài)及血清激素方面改變與人類多囊卵巢綜合征的病理改變加以比較一女被多男玩喷潮视频免费观看，探討睪酮聯(lián)合HCG是否是建立多囊卵巢大鼠模型的有效方法，并比較兩種造模法是否存在異同點(diǎn)国产做a高清免费视频，判斷哪一種造模方法更為理想及簡便有效免费不卡在线毛片。

TyPe II collagen induced arthritisln the rat ank1e joint andoVathumin as antigen induced arthritis WA in the rabbit knee joint wereestab1ish2 Qualitative evaluation of me in skin, muscle, synovium, cedilagearound joint and blood was performed by OMA3 The CIA rats were treated on day 7 after hind paw swelling and erythemaAnimals were injected intravenously with ase at a dose of 10mg/kg,tWenty minuots 1ater, one ankle of the rats random1y assigned was exPosedlaser irradiation at l00J/cm fOr l000 seconds, and another ankle wasM grouP wihout laser The other two groups is unmanipulatedcontrol group and untreated CIA group Bimaleolar ankle widthmeasuremellts were taken in all animals every tWo days using amicrometer The histopathology of the ank1e Joint was assessed at day 21after disease onset4 The pro1iferating cell nuclear antigen WCNA of CIA treated by PDT andthe HMME group without laser was doterdrined by immunohistochemiStry5 The AfA rabbits were treated on day 7 after knee swelling and erythemaThe theraPy invo1ved lntravenous injection of l0mg/kg HMME, fOl1owedby 20 minues period in dim light, and transdermal light treatment with\l00 J/cm2 fOr l000 seconds The inner sides of the treated Anees wereirradiated at first, and then the outer side did 24 hours later, the synovialtissue of the Anees joint were removed and in situ cel1 aPoptosis wasdetCCted With tednal deoxync1eotidyl transferase-mediated dUTP nickend labelingR6suIt8:l The pathologic changes of CIA and AIA include subsynovial inflammation,opovial hyPerplasia, pannus formation, cartilage and bone destructionresemble RA.2 The studies demonstrated that there are different uptake of HMME withinskin, muscle, synovium, cartilage and b1ood, and the synovium cou1draPidly uPtake more ase than skin and cartilage at the firSt 30 minuesaller intravenous injection of HMME3 The bimaleolar anke width had no different among PDT treated group,H group withollt 1aser and untreated CIA group But hlstologicalevaluation showed statiStical1y significallt reductions in synovialhyperplasia, pannus formation and cart1lage reosion, bone destruction andtotal score in PDT treated group4 Image analysis showed that the ratlo bforeen the areas of the coufltedobect to that of the entire area in PDTtreated grOup is lower than that in conirol group, but the integrated oPticaldensity had no different between the two groups5 Imape analysis showed that the ratio between the area of the countedobject to that of the e

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He waited till Mole's sobs became gradually less stormy and more rhythmical; he waited till at last

河鼠等著，等到鼴鼠的哭泣逐漸緩和下來久久扭，不再是狂風(fēng)暴雨国产av一码二码三码无码，而變得多少有節(jié)奏了，等到鼴鼠只管抽鼻子丁香六月深婷婷综合五月，間或夾雜幾聲啜泣中文字幕无码毛片一级。

He waited till Mole's sobs became gradually less stormy and more rhythmical; he waited till at last sniffs were frequent and sobs only intermittent.

河鼠等著，等到鼴鼠的哭泣逐漸緩和下來rihanhuangsewangzhan，不再是狂風(fēng)暴雨婷婷丁香五月综合中文字幕，而變得多少有節(jié)奏了，等到鼴鼠只管抽鼻子18岁进看的黄色网站，間或夾雜幾聲啜泣火热福利视频导航。