Goal compound synthesis namely: Take the vanillic acid as outset raw material, obtains 4- hydroxyl - 3- anisole methyl formate with the methyl alcohol reflux conditions, then after the etherification, the nitration, the return to original state, the ring closure response obtains 6- methoxy - 7- animal pen oxygen radical kui zuo lin - 4- alkone, then passes through the chlorination, the substitution aniline, to escape responses again and so on animal pen oxygen radical, etherification to obtain the goal compound; The goal compound and the diethylamine had the amine substitution reaction to obtain TM1, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(N, N- two ethyl aminos) third oxygen radical] kui zuo lin; Through zuo has the etherification with the Austria niter to respond obtains TM2, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(2- methyl - 5- nitryl imidazole) third oxygen radical] kui zuo lin.

目標(biāo)化合物的合成即：以香草酸為起始原料国产一级毛片又粗又黄又硬，與甲醇回流條件下得到4-羥基-3-甲氧基苯甲酸甲酯日韩裸体自拍视频网站免费观看网址，然后經(jīng)過醚化、硝化免费在线黄视频播放、還原日韩久久无码AV毛片、環(huán)合反應(yīng)得到6-甲氧基-7-芐氧基喹唑啉-4-酮，然后再經(jīng)氯化无毒国产水多视频在线、取代苯胺久久亚洲精品无码福利播放、脫芐氧基、醚化等反應(yīng)得到目標(biāo)化合物国产白嫩在线观看视频；目標(biāo)化合物與二乙胺發(fā)生胺取代反應(yīng)得到了TM1乱伦网站97，即4-苯氨基-6-甲氧基-7-[2-羥基-3-丙氧基]喹唑啉；通過與奧硝唑發(fā)生醚化反應(yīng)得到TM2欧美三级片又粗又长，即4-苯氨基-6-甲氧基-7-[2-羥基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉99re视频这里只有精品在。

Based on the synthesis method and the function of decreasing blood glucose levels of rosiglitazone, and the report on benzoquinones which resulted in a significant decrease in blood glucose levels, a novel non-thiazolidinedione class of PPARy agonist 2, 5-Dihydroxy-3-{4-[2-(methyl- pyridin-2- yl-amino)- ethoxy] -phenyl}-6-phenyl-[l, 4] benzoquinone (4) was designed and synthesized.

在合成羅格列酮的基礎(chǔ)上，根據(jù)某些醌類結(jié)構(gòu)化合物的類似胰島素作用国内偷拍人妻，設(shè)計并合成了一種非噻唑烷二酮類PPARγ激動劑2人人爱人人摸2020人人操，5-二羥基3-{4-[2-(甲基-2-吡啶氨基)-乙氧基]-苯基}-6-苯基-1，4苯醌(4)久久99精品这里精品,9。

Bezaldehyde was used as protective agent in first method.S-Epichloeohydrin was aminated and acidulated to give(2S)-1-Amino-3-chloro-propanol Salts.The acetylation of (2S)-1-Amino-3-chloro-propanol by acetic anhydride produced the intermediate-N-[2--3-chloropropyl]acetamide.And then at 20℃,in the presence of lithium tert-butoxide,benzyl 3-fluoro-4-morpholinophenyl carbamate react with-N-[2--3-chloropropyl]acetamide to give linezolid in total yield of 43.6%.

路線一采用苯甲醛作保護劑99r精品在线观看，使S-環(huán)氧氯丙烷氨解、酸化生成S-1-氨基-3-氯-2-丙醇鹽酸鹽亚洲色图欧美色图日本，然后經(jīng)乙跖访佬园?区；磻?yīng)后人人色人人橾人人色人人橾，生成中間體-N-[2-乙酰氧基-3-氯丙基]乙酰胺，再用N-(3-氟-4-嗎啉苯基)氨基甲酸芐酯和中間體在催化劑叔丁醇鋰存在下25℃反應(yīng)生成利奈唑酮黄色三级网，總產(chǎn)率達(dá)到43.6%黄色视频免费区。