In chapterⅡ, considering GLMMs data which the number of high units is different and the number of low units is small and unbalanced, we Conduct a series of simulations, the simulations show that regardless of the number of the level 2 units,the Bayesian estimate of random effects residual variance is more precise than PQL and the PQL estimation deviates from the true value seriously; In terms of the fixed effects estimates, When the number of level 2 units is 20, The mean and median of the Bayesian estimate is more precise than PQL,But With the number of level 2 units increase,the estimate of two methods is similar. Thus, in practical applications, we recommend the use of Bayesian method.

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This paper has studied the physiological and biochemical changes during the period of forming strong buds of tree peony, and expect to provide academic basis for extending its view value and economic benefit . The main results are as the following:1 Under the field condition, Characteristics of photosynthesis of tree peony are very regular. From before blooming to the prophase of abducting buds that after blooming ,that is April,May and June,the net photosynthetic rate of tree peony is higher than the other period .It indicates that this period is very important for accumulating photosynthetic products of tree peony . So, if we want to get quality flower of tree peony ,it is very important to strengthen the management of tree peony cultivation and to ensure provide the fertilizer and water.2 From the middle ten days of June, with the time elapsing and with the environment conditions worsening, the characteristics of photosynthesis of tree peony decline deeply. But it is different among different tree peony breeds. For example , cv. Wu Long Peng Sheng can also has higher net photosynthetic rate, it indicates that cv. Wu Long Peng Sheng is super than the other two tree peony breeds when adapting the environment conditions and cv. Wu Long Peng Sheng has wide prospect to extend .3 The main factors of effecting the characteristics of photosynthesis are stomatal factor and non-stomatal factor ,that is the ability of photosynthesis of leaf cells. Under the environment of high light intensity in midsummer, if overshadow tree peony properly, then it can slow the declining of chlorophyll content, and increase the net photosynthetic rate and benefit for the accumulating of photosynthetic products.4 The content of soluble sugar in the root of tree peony is the highest among different organs during the period of forming strong buds . According to analyse ,we believe that the soluble sugar will compose starch then, and provide the solid base of material for the growth and development next year. It provide us strong academic basis of adopting the method of cultivating root and protecting root under thefield environment conditions .In other words ,it will help to increase the health level of the whole plant of tree peony and will be beneficial to forming quality tree peony flower if we strengthen the management of root. 5 To tree peony, the endogenesis hormone is important for its growth and development .In the prophase ,that is about the blooming of tree peony and the mid-summer ,IAA and ZR contents are higher and GA content is lower and its changes are very little, and the content of ABA is decreasing . This indicates that IAA and ZR act the important promote function for growth and development of tree peony in this period, and the function of GA is not important. Bur in the period of anniversary senescence of tree peony , the content of IAA and ZR begin to decrease ,while the ABA content has a certain rebound .T

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Serum level of TNF-α was measured by unsaturation assay; Serum level of IL-2国产视频精品91、IL-6、 IL-10 were measured by radioimmunoassay.

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In the first section, the effect of sodium houttuyfonate on the level of lysozyme secreted by macrophages was first tested by bacteriolytic method; then the effect of sodium houttuyfonate on the level of tartaric acid resistant acid phosphatase produced in macrophages was investigated by analyzing the phenol generated in the reaction that was catalyzed by the enzyme; the third, the effect of sodium houttuyfonate on the phagocytic activity of macrophages was observed by microscopy; the forth, the effect of sodium houttuyfonate on the production of complement C4 from macrophages was tested by hemolytic method; the fifth, the effect of sodium houttuyfonate on the expression of C3b receptors on the surface of macrophages was analyzed by observing the formation percentage of zymosan wreath; the sixth, the effect of sodium houttuyfonate on the respiratory burst in macrophages was tested by flow cytometry; the seventh, the effect of sodium houttuyfonate on the production of IL-1α and IL-1β from macrophages was tested by ELISA method.

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The head is slowly turned 90° toward the side where nystagmus is induced less intensely. Then the head is rotated 180° rapidly toward the opposite side. This article reports three cases of the ageotropic form of HC-BPPV that were cured by rapid head rotation. The three cases demonstrated that rapid head rotation was an effective maneuver to treat cupulolithiasis on the utricle side. It is recommended that rapid head rotation can be used for therapeutic diagnosis: If nystagmus subsides immediately after this maneuver, the diagnosis is cupulolithias is on utricle side. If nystagmus changes into the geotropic form, the diagnosis is cupulolithiasis on canal side or canalolithiasis in the anterior arm of horizontal semicircular canal. A repositioning maneuver for geotropic form can then be applied to treat these patients.

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Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

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Supplement of pyruvate can increase serum LPL levels remarkably(p.05)and decrease serum HL level but no significant statistical difference in rats and swimming rats, decrease serum T4 levels during resting obviously(p.05)in rats and reduce serum T4 levels to certain extent in swimming rats. It indicated that pyruvate supplement could regulate lipometabolism in rats and swimming rats by means of the effect on enzyme and hormone levels.

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Venous blood was drawn from 35 old hypertension patients when blood pressure was nomial and abnormal, respectively. Epinephrine. norepinephine, endothelins, angiotensin Ⅱ and calcitonin-gene-related peptide were determined by radio-immunity. The above five cytokines were also determined in 33 old healthy people. The cytokines levels were compared between the normal and abnormal blond pressure in hypertension patients and also between the old hypertension patients and healthy persons. The correlation between blood pressure and cytokines were analyzed.

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According to the definition of OCSP, patients were classified into the following 4 clinical subgroups:total anterior circulation infarcts, partial anterior circulation infarcts, lacunar infarcts, and posterior circulation infarcts by 1 neurologist.The frequencies were compared between subgroups, In the subgroup of which frequency was hightest, progressive and nonprogressive patients were compared in terms of the following variables:age, gender, hypertension,diabetes mellitus,cigarette smoking, The Canadian Neurological Scale Score at entry, systolic blood pressure at entry,fever at entry(body temperature37°C),stochastic blood glucose at entry, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, fibrinogen, large-artery atherosclerosis (50% stenosis or occlusion of the corresponding artery).

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RESULTS Plasma levels of IL-8, IL-10, MMP-9 were higher at 1 h, 4 h and 6 h aortic dclamping off in continuous ventilation and the nonventilation group, and IL-8 level were significantly higher in nonventilation group compared with ventilation group, IL-10 levels were significantly higher in the ventilation group than nonventilation group after 1 h and 4 h, 6 h, TIMP-1 levels were significantly higher in the ventilation group than that in nonventilation group after 1 h and 4 h.

TIMP-1的血漿水平在術后持續(xù)升高亚洲一级二级，在術后1 h和4 h持續(xù)通氣組較非通氣組明顯增高。血漿中TXB2水平在主動脈開放后1 h亚洲国产精品无码网、4 h和6 h明顯高于術前水平国产一区在线观看免费你懂的，持續(xù)通氣組較非通氣組水平明顯降低。支氣管肺泡灌洗液中IL-8欧美性爱丫丫丫、IL-10台湾农村寡妇特级A毛片、MMP-9和TXB2 水平在主動脈開放后4 h較術前明顯升高。