Then Doripenem came into the market in the July ,2005. We studied the synthesis of Doripemen.Firstly, we synthesized the chemical 2 from the starting material------o-hydroxylphenylacylamine through Reformastky reaction, alkylation, Diekmann reaction, enolization, esterification and etc. Secondly, we synthesized the chemical 3 from L — hydroxylproline through the protection of carboxyl, amidogen and hydroxyl group, reduction by NaBr, SN_2 substitution and Mitsumobu reaction.

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It was shownthat, among the three possible tautomers; i.e., the keto-form and the two enol forms, and thecorresponding enol anion, only the enol form 31 was actually responsible for the singletoxygen reactions.

用核磁共振及從頭算法研究了化合物12b和23a在甲醇和吡啶中的烯醇化作用日本女优一区，結(jié)果表明，在其三種互變異構(gòu)體以及相應(yīng)烯醇負(fù)離子中啪啪啪一级，只有烯醇式31是實(shí)際參與單重態(tài)氧反應(yīng)的成份在线观看黄A片。

Phosphoglycerate is converted to 2-phosphoglycerate by phosphoglycerate mutase.

2-磷酸甘油酸在烯醇化酶的催化下生成磷酸烯醇式丙酮酸。

From the femur bone density analysis of protein expression, we can see that light chain lactoferrin, annexin decreased and the expression of enolase, ATP synthase, acetyl-coenzyme A reductase, the expression of troponin, may be related to ovariectomized femoral bone density in osteoporosis-related happened; strong bone of the femoral osteoporosis Po intervention effect may be related to reduced enolase, ATP synthase, troponin, CK-MB, acetyl phosphoglycerate enzyme, the expression of myosin, and the increase in lactoferrin light chain, pyruvate kinase isoenzyme, protein expression crown.

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Cancellous bone from the lumbar proteomic expression analysis show that actin, keratin, enolase, ATP synthase, the expression of myosin may be related to ovarian lumbar cancellous bone after osteoporosis-related happened; Qiang Gu Bao Po on the lumbar spine osteoporosis intervention effect may be related to reduced carbonic anhydrase, actin, crystal protein, 3- phosphoglycerate dehydrogenase, serum albumin, ATP synthase, myosin, the enolase expression.

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Second, using DBU as the base for enolization of propargylic esters of unsaturated acids 18e-k, we developed a tandem Ireland-Claisen rearrangement /isomerization reactions. It has been shown that the reaction sequence affords triene molecules 42a-b and 43a-b in moderated to high yields. Interestingly, with allyl hexa-3,5-dienoates 18i-j as the substrate, the rearranged products underwent further aromatization to give uniquely substituted benzyl acids 44a-b.

其次，以含有活潑質(zhì)子的烯酸炔丙酯18e-k為底物中老年女人A片，在DBU為烯醇化堿av免费在线观看网站大全、TMSCl為硅試劑的條件下，底物18e-h發(fā)生了Ireland-Claisen重排/異構(gòu)化串聯(lián)反應(yīng)国产日韩成人香蕉软件，得到完全共軛的三烯類(lèi)化合物42a-b及43a-b看美女被操久久精品；而以己二烯酸炔丙基酯18i-j為底物時(shí)，重排/異構(gòu)化后的產(chǎn)物進(jìn)一步發(fā)生電環(huán)化等反應(yīng)最終得到芳構(gòu)化產(chǎn)物——取代苯甲酸類(lèi)化合物44a-b538视频在线播放欧美。

We researched on the prepartion of pivotal intermediate 2 and 3 for 1 P-methyl carbapenem antibiotics from intermediate 1, which is subjected to Reformastky reaction, N-alkylation, Dieckmann-type cyclisation, enolization, ester condensation etc. in sequence. The synthesis route of document is optimized by us.

我們研究了1β-甲基碳青霉烯類(lèi)重要中間體的合成在线人成，從中間體1出發(fā)經(jīng)Reformastky反應(yīng)、水解反應(yīng)合成出中間體2欧美成三级；經(jīng)Reformastky反應(yīng)免费观看色视频网站、烷基化、Dieckmann環(huán)合黄色网站男人天堂、烯醇化www.操逼.com、酯化合成出中間體3，并對(duì)其中各步反應(yīng)作了優(yōu)化和探索爽到高潮嗷嗷嗷叫视频软件。

We studied DBU-mediated Ireland-Claisen rearrangement. Using DBU as the base for enolization of allylic esters of unsaturated acids 9-16, we found a novel DBU-mediated tandem Ireland-Claisen rearrangement /isomerization reactions and established a consecutive Ireland-Claisen rearrangement /Cope rearrangement.

利用DBU作為烯醇化堿不卡性爱视频，對(duì)含有活潑質(zhì)子的烯酸烯丙酯類(lèi)化合物9-16的Ireland-Claisen重排進(jìn)行了系統(tǒng)的研究，創(chuàng)建了一條新穎的DBU-促進(jìn)的Ireland-Claisen重排/異構(gòu)化串聯(lián)反應(yīng)及Ireland-Claisen重排/Cope重排的串聯(lián)反應(yīng)路線(xiàn)成一级在线视频。

Other methyl nucleophiles includingMeMgBr, MeCeCl2, MeTiCl3, Me3Al, Me3ZnMgCl, MeMnClwere tried, but in all these cases no detectable amount of exo-C8-methylated product was obtained. Although protecting C3-carbonyl as 1,3-dioxolanes could be achieved, the serious enolization of C8-carbonyl was still problematic. Converting C9-furan ring to α,β-butenolide did depress the enolization, but desired C8-methylation was completely replaced by migration of the double bond of the butenolide.

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Finally confirmed that,The thighbone and the osteoporosis morbidity is possibly connected protein 6, respectively are: The lactoferrin light chain, membrane association protein A3, the enolase, ATP gather the enzyme, the acetyl coenzyme A reductases, the myo calcium protein; The lumbar vertebra and the osteoporosis morbidity is possibly connected protein 5, respectively are: The actin, the keratin, the enolase, ATP gather the enzyme, the myosin; The thighbone and the strong bone valuable curative effect is possibly connected protein 9, respectively are: The enolase, ATP gather the enzyme, the myo-calcium protein, the creatine activating enzyme isozyme, the phosphoglyceric acid change flavor the enzyme, the myosin, the lactoferrin light chain, the pyruvic acid activating enzyme isozyme, the crown protein; The lumbar vertebra and the strong bone valuable curative effect are possibly connected protein 8, respectively are: The carbonic anhydrase, the actin, the αB-crystal protein, 3-phospho-glycerol aldehyde oxidase, the serum albumin, ATP gather the enzyme, the myosin, the enolase.

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