This invention provides compounds of Formula; wherein: R is a moiety selected from the group: and n is an integer of 1 or 2; R is selected from hydrogen, amino,-NRR, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted, halogen, and a 5 to 10 membered heteroaryl ring optionally substituted, having 1 to 4 heteroatoms independently selected from N, O and S; R is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R is H, alkyl of 1 to 12 carbon atoms optionally substituted, cycloalkyl of 3 to 8 carbon atoms, bicycloalkyl of 5 to 10 carbon atoms or aralkyl optionally substituted; R is OH or -OH; R and R are each independently H or alkyl of 1 to 12 carbon atoms or when optionally taken together with the nitrogen atom to which each is attached form a 3 to 8 membered saturated heterocyclyl ring; R is alkyl of 1 to 12 carbon atoms optionally substituted; or a tautomer or pharmaceutically acceptable salts thereof.

本發(fā)明提供式的化合物；其中：R 1 為選自基團和的部分jizz有基视频色欲；n為整數(shù)1或2av毛片对白；R 2 選自氫、氨基1024免费手机视频、-NR 6 R 7 毛片三级片A片、具有1到12個碳原子的視情況經(jīng)取代的烷基、具有6個美女搞逼黄色视频免费的、10個或14個碳原子的視情況經(jīng)取代的芳基欧美久久精品AAAA片、具有2到12個碳原子的視情況經(jīng)取代的烯基、具有2到12個碳原子的視情況經(jīng)取代的炔基www.hp黄片免费A片、鹵素和具有1到4個獨立地選自N吉吉电影网午夜理论片、O和S的雜原子的視情況經(jīng)取代的5元到10元雜芳基環(huán)；R 3 選自氫久久综合视频永久、具有1到12個碳原子的視情況經(jīng)取代的烷基一级片a片在线视频、具有6個、10個或14個碳原子的視情況經(jīng)取代的芳基国产精品4huWWW、具有2到12個碳原子的視情況經(jīng)取代的烯基免费A片黄片、乙烯基、具有2到12個碳原子的視情況經(jīng)取代的炔基和鹵素日本特毛AAAAAA片；R 4 為Hwww.26uuu.com、具有1到12個碳原子的視情況經(jīng)取代的烷基、具有3到8個碳原子的環(huán)烷基91嫩草国产在线看网站、具有5到10個碳原子的雙環(huán)烷基或視情況經(jīng)取代的芳烷基国产一级毛片无码夜夜爽；R 5 為OH或-OH 8 ；R 6 和R 7 各自獨立地為H或具有1到12個碳原子的烷基黄色激情视频一区，或當視情況與其所連接的氮原子連接在一起時形成3元到8元飽和雜環(huán)基環(huán)又黄又爽又湿的视频；R 8 為具有1到12個碳原子的視情況經(jīng)取代的烷基；或其互變異構體或醫(yī)藥學上可接受的鹽黄色录像免费看久久。

In this thesis, 1, 5-diaryl-3-pyrazilidinones, 1, 5-diaryl-3-hydroxypyrazoles and 3-(2, 3, 4, 6-tetraacetyl-β-D-glucopyranos-1-yl)-1, 5-diaryl-1H-pyrazoles are designed and synthesized.1, 5-diaryl-3-pyrzolidinones were obtained by condensation of 3-arylpropenates and phenylhydrazine or fluorophenylhydrazine under the catalysis of sodium methylate and the yields were about 55-80%.

在本文中国产久久99，設計合成了1，5-二芳基-3-吡唑烷酮化合物亚洲一区二区精品91眼镜、1欧美坐爱视频，5-二芳基-3-吡唑烷酮化合物和3-(2，3人妻AV资源网，4欧美在线中文字幕整片视频网站免费，6-四乙酰基-β-D-吡喃葡萄糖-1-基)-1亚洲鸥美国产毛片，5-二芳基吡唑化合物十八岁以下禁看的黄片视频。以3-芳基-2-丙烯酸酯為原料黄页三级，與芳基肼在醇鈉的催化作用下，反應可以生成1久久亚洲一区二区三区明星换脸，5-二芳基-3-吡唑烷酮黄色网站啊啊嗯……，產(chǎn)率在55%以上。

In chapter 4 an abnormal reaction that the nitro group of 1-aryl-2-nitroethenescan be easily replaced by the organic moity of FG-RZnI using Ni〓 and tertiaryamine as catalyst was first given. The experimental results show that in the presenceof catalytic amount of Ni〓 and tertiary amines, the reaction of FG-RZnI andl-aryl-2-nitroethenes give the substitution products l-aryl-l-alkene, instead ofMichael addition products.

通過實驗發(fā)現(xiàn)福利免费视頻，在催化量的Ni〓及叔胺催化下， l-硝基-2-芳基乙烯與烷基碘化鋅并不進行Michael加成反應在线欧美成人免费播放，而是發(fā)生1-硝基-2-芳基乙烯中硝基被取代的反應久久久噜噜噜久久三级，生成了高產(chǎn)率的1-芳基-l-烯烴，由于此反應的原料易得偷拍盗射、反應條件溫和在线观看成人精品电影视频网站、產(chǎn)物的產(chǎn)率高，因而是合成l-芳基-1-烯烴的有效方法欧美日韩中文字幕综合一区二区人妻。

The compounds are represented by the structural Formula 1, Chemical formula should be inderted here as it appears on the abstract in paper form. a prodrug thereof, or any pharmaceutically acceptable salt, solvate, isomer or racemic mixture of the compound or said prodrug wherein R1 is heteroaryl, N-arylaminocarbonyl, N-heteroarylaminocarbonyl, benzimidazolyl or benzothiazolyl; R15 is present or not and if present is H, aryl, alkyl, arylalky or heteroarylalkyl; A is aryl, heteroaryl, cycloalkyl, cycloalkylidene, heterocycloalkylidene or heterocycloalkyl wherein said aryl, heteroaryl, cycloalkyl, cycloalkylidene, heterocycloalkylidene and heterocycloalkyl moieties may be substituted or unsubstituted; and B, L, X and R18 are defined herein.

所述化合物用結構式1表示889avav，包括其前藥或所述化合物或所述前藥的任何藥學上可接受的鹽、溶劑合物aV免费中文在线观看网站、異構體或外消旋混合物2021国产在线小视频91，其中R 1 為雜芳基、N-芳基氨基羰基亚洲综合色国产五月一区二区三区、N-雜芳基氨基羰基污黄色深夜免费网站、苯并咪唑基或苯并噻唑基；R 15 存在或不存在黄色有限公司的网站在线进入，如果存在99国产精品黄网站，則為H、芳基欧美性猛交XXXXX按摩欧美、烷基AV天堂综合网、芳基烷基或雜芳基烷基；A為芳基在线观看黄色的网站、雜芳基黄色网站老女人、環(huán)烷基、環(huán)烷叉基超碰免、雜環(huán)烷叉基或雜環(huán)烷基国产操人，其中所述芳基、雜芳基激情视频永久在线、環(huán)烷基国产首页在线、環(huán)烷叉基、雜環(huán)烷叉基和雜環(huán)烷基部分可被取代或未被取代欧美日韩另类国产；B粗壮公每次进入让我次次高潮、L给个黄色激情性爱网站、X和R 18 如說明書所定義。

Also useful are oil-soluble copper dithiocarbamates of the general formula Rc Rd z Cu, where z is 1 or 2, and Rc and Rd are the same or different hydrocarbyl radicals containing from 1 to 18, and preferably 2 to 12, carbon atoms, and including radicals such, for example, as alkyl, alkenyl, aryl, aralkyl, alkaryl and cycloaliphatic radicals.

化學通式為Rc Rd z Cu的油溶性二硫代氨基甲酸銅也適用啪啪免费网站大全，式中国产一级A片免费观看视频，z為1或2，Rc和Rd是含1～18（以2～12為宜）個碳原子的相同或不同的烴基欧日韩XX视频在线观看网站，這類烴基的實例包括烷基综合操逼网、烯基、芳基97超碰,人摸人人人澡人人、芳烷基国产久在线视频观看、烷芳基和脂環(huán)基。

In this thesis, two series compounds of thiadiazole (2a~2f) and benzothiazole (5a~5f) were synthesized by using the reagent of iodobenzene diacetate. We also bound the iodobenzene diacetate reagent to the resin and applied it to synthesize thiadiazole and benzothiazole compounds.

本文利用二醋酸碘苯試劑分別與1-芳甲跆焯煲古鋈杖彰杖赵瑁基-5-芳基-2-硫代縮二脲及1-芳甲趸粕缬敖?8国产；?3-芳基硫脲反應合成了噻二唑(2a~2f)和苯并噻唑(5a~5i)兩個系列的雜環(huán)衍生物，并通過把二醋酸碘苯負載在高分子上合成了一類新型的固相氧化劑亚洲自偷自偷偷色无码中文，同時考查了該固相氧化劑在噻二唑新国模吧，苯并噻唑類化合物合成中的應用以及該固相氧化劑的循環(huán)使用。

The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted C1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het1, Het2; R1 may also be a radical of formula (R11aR11b)NC(R10aR10b)CR9-; t is 0, 1 or 2; R2 is H or C1-6alkyl; L is -C-,-O-C-,-NR8-C-,-O-C1-6alkanediyl-C-,-NR8-C1-6alkanediyl-C-,-S2-,-O-S2-,-NR8-S2 ; R3 is C1-6alkyl, aryl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, or arylC1-4alkyl; R4 is H, C1-4alkylOC, carboxyl, aminoC, mono- or di(C1-4alkyl)aminoC, C3-7cycloalkyl, C2-6alkenyl, C2-6alkynyl or optionally substituted C1-6alkyl; R5 and R6 are H or C1-6alkyl.

本發(fā)明涉及右式化合物其N-氧化物这里只精品视频、鹽欧美特黄在线视频、立體異構形式、外消旋混合物插黄网站、前藥二级A片视频、酯及代謝物，其中R 1 及R 8 各是氫日韩精品欧美大片资源在线观看、C 1-6 烷基美女医生被操免费网站、C 2-6 烯基、C 3-7 環(huán)烷基欧美熟女性爱爱、芳基亚洲欧美激情一区二区、Het 1 、Het 2 乱妇乱女熟妇熟女网站；R 1 也可以是式(R 11a R 11b )NC(R 10A R 10b )CR 9 -之基口爆吞精一区二区久久；t是0、1或2欧洲黄片毛片；R 2 是氫或C 1-6 烷基欧美少妇一级黄片；L是-C-、-O-C-免费一级持黄网、-NR 8 -C-91精品国产久无码、-O-C 1-6 烷二基-C-、-NR 8 -C 1-6 烷二基-C-人干人操人、-S 2 -无码国产一区二区免费，-O-S 2 -欧美性爱操比黄色视频在线观看、-NR 8 -S 2 -；R 3 是C 1-6 烷基欧美色网址、芳基国产女主播喷水视频在线观看、C 3-7 環(huán)烷基、C 3-7 環(huán)烷基C 1-4 烷基或芳基C 1-4 烷基中文字幕无码免费久久9一区9；R 4 是氫a片www免费看、C 1-4 烷基OC、羧基日韩va欧美中文字幕在线、氨基C91尤物无码国产在线观看、一-或二(C 1-4 烷基)氨基C、C 3-7 環(huán)烷基特板人人操556、C 2-6 烯基日韩欧美精品中文字幕、C 2-6 炔基或任選被取代的C 1-6 烷基www.超碰在线观看；R 5 及R 6 是氫或C 1-6 烷基花季传媒视频免费观看ios。

Base played a crucial role in this reaction: in the Pd2/L1 catalyzed α-arylation of ethyl malonate, K3PO4 is the base of choice; in the α-arylation of ethyl acetoacetate, K2CO3 is the most effective base.

在這類催化反應中，堿的選擇具有重要的影響：以K3PO4為堿国产在线偷窥视频网址， Pd2/L1催化體系在丙二酸二乙酯的α-芳基化中91POPN九色，富電子溴代芳烴顯示較好的活性； Pd2/L1催化的乙酰乙酸乙酯α-芳基化時欧美a在线视频，以 K2CO3為堿原创av，催化體系顯示較好的活性，這個催化體系可控制反應得到α-芳基乙酰乙酸乙酯毛片网址播放，而不是脫乙豕执笥灿炙夥咽悠担基的產(chǎn)物。

Base played a crucial role in this reaction: in the Pd2/L1 catalyzed α-arylation of ethy malonate, K3PO4 is the base of choice; in the α-arylation of ethyl acetoacetate, K2CO3 is the most effectiv base.

在這類催化反應中欧美人www免费一区，堿的選擇具有重要的影響：以K3PO4為堿中文字幕,大黄片，Pd2/L1催化體系在丙二酸二乙酯的α-芳基化中，富電子溴代芳烴顯示較好的活性a片手机在线一级一区；Pd2/L1催化的乙酰乙酸乙酯α-芳基化時欧美一级激情操逼aaa黄，以K2CO3為堿，催化體系顯示較好的活性h色在线，這個催化體系可控制反應得到α-芳基乙酰乙酸乙酯全色色网2021，而不是脫乙酰基的產(chǎn)物手机黄网国产视频。

Examples of metal chelating groups include hydroxides especially aryl or heteroaryl hydroxides such as phenolic hydroxides; amines which may be aliphatic aryl or heteroaryl; mercaptans which may be aliphatic aryl or heteroaryl; carboxylic acids which may be aliphatic aryl or heteroaryl; oximes and ketoximines; acetarylamides; hydroxy silanes and silicones; N-containing heterocycles such as imidazoles benzimidazoles triazoles benzotriazoles thiazoles isothiazoles acid anhydrides and more preferably acid groups (especially carboxylic acid groups phosphoric acid groups polyphosphoric acid groups phosphonic acid groups sulphuric acid groups and sulphonic acid groups).

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